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Oxygen Free-Radical Reduction of Brain Capillary Rubidium Uptake

dc.contributor.authorLo, Warren D.en_US
dc.contributor.authorBetz, A. Lorrisen_US
dc.date.accessioned2010-04-01T15:20:28Z
dc.date.available2010-04-01T15:20:28Z
dc.date.issued1986-02en_US
dc.identifier.citationLo, Warren D.; Betz, A. Lorris (1986). "Oxygen Free-Radical Reduction of Brain Capillary Rubidium Uptake." Journal of Neurochemistry 46(2): 394-398. <http://hdl.handle.net/2027.42/65815>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65815
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3001225&dopt=citationen_US
dc.description.abstractFree radicals are proposed to play a role in the injury following cerebral ischemia in which cerebral edema is a prominent feature. To determine whether free radicals might alter the movement of ions and water across the blood-brain barrier, we examined their effect on brain capillary transport. Rat brain capillaries were isolated, incubated with a system that generates free radicals, and various capillary transport systems were studied. Rubidium uptake was reduced 74% whereas rubidium efflux, glucose transport, and capillary water space were unchanged. The results following the addition of radical scavengers indicated that hydrogen peroxide or a related free radical was the toxic species. These data suggest that free radicals can impair capillary endothelial cell mechanisms that help maintain homeostasis of electrolytes and water in brain.en_US
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dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1986 International Society for Neurochemistryen_US
dc.subject.otherFree Radicalsen_US
dc.subject.otherBrain Capillariesen_US
dc.subject.otherCerebral Ischemiaen_US
dc.subject.otherNa +en_US
dc.subject.otherK + -ATPaseen_US
dc.subject.otherBlood-brain Barrieren_US
dc.subject.otherRubidium Transporten_US
dc.titleOxygen Free-Radical Reduction of Brain Capillary Rubidium Uptakeen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Pediatrics and Neurology, University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.identifier.pmid3001225en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65815/1/j.1471-4159.1986.tb12981.x.pdf
dc.identifier.doi10.1111/j.1471-4159.1986.tb12981.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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