Lymphocyte mitogenesis, immunoglobulin and complement levels in depressed patients and normal controls
dc.contributor.author | Kronfol, Ziad A. | en_US |
dc.contributor.author | House, J. Daniel | en_US |
dc.date.accessioned | 2010-04-01T15:22:14Z | |
dc.date.available | 2010-04-01T15:22:14Z | |
dc.date.issued | 1989-08 | en_US |
dc.identifier.citation | Kronfol, Z.; House, J. D. (1989). "Lymphocyte mitogenesis, immunoglobulin and complement levels in depressed patients and normal controls." Acta Psychiatrica Scandinavica 80(2): 142-147. <http://hdl.handle.net/2027.42/65846> | en_US |
dc.identifier.issn | 0001-690X | en_US |
dc.identifier.issn | 1600-0447 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/65846 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2801162&dopt=citation | en_US |
dc.description.abstract | The central nervous system and the immune system are closely related. Psychiatric illness is often associated with a dysregulation of the immune response. In an attempt to expand on previously reported immune abnormalities in patients with depressive illness, we compared several immune measures in a group of hospitalized depressed patients and healthy normal controls. Depressed patients had significantly higher percentages of circulating neutrophils, significantly lower percentages of circulating lymphocytes and significantly lower in vitro lymphocyte responses to mitogenic stimulation than normal controls. Basal plasma cortisol and circulating levels of the complement components C3 and C4 were also higher in the depressed group. We also found a significant association between cortisol values and the traffic of leukocytes on the one hand, and complement levels and the lymphocyte mitogenic activities on the other. These findings expand previously reported evidence of immune abnormalities in depressive illness and provide a partial explanation for some of these findings. | en_US |
dc.format.extent | 423917 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1989 Blackwell Publishing Ltd | en_US |
dc.subject.other | Depression | en_US |
dc.subject.other | Lymphocyte | en_US |
dc.subject.other | Complement | en_US |
dc.subject.other | Immunity | en_US |
dc.subject.other | Affective Disorder | en_US |
dc.title | Lymphocyte mitogenesis, immunoglobulin and complement levels in depressed patients and normal controls | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan, Iowa, USA | en_US |
dc.contributor.affiliationother | Department of Family Practice, University of Iowa College of Medicine, Iowa City, Iowa, USA | en_US |
dc.identifier.pmid | 2801162 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/65846/1/j.1600-0447.1989.tb01316.x.pdf | |
dc.identifier.doi | 10.1111/j.1600-0447.1989.tb01316.x | en_US |
dc.identifier.source | Acta Psychiatrica Scandinavica | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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