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IRREVERSIBLE ZINC ION INHIBITION OF (Na + -K + )-ADENOSINETRIPHOSPHATASE, Na + -PHOSPHORYLATION, AND K + -p-NITROPHENYLPHOSPHATASE OF ELECTROPHORUS ELECTRICUS ELECTROPLAX 1
dc.contributor.authorGettelfinger, Dennis M.en_US
dc.contributor.authorSiegel, George J.en_US
dc.date.accessioned2010-04-01T15:32:38Z
dc.date.available2010-04-01T15:32:38Z
dc.date.issued1978-11en_US
dc.identifier.citationGettelfinger, Dennis M.; Siegel, George J. (1978). "IRREVERSIBLE ZINC ION INHIBITION OF (Na + -K + )-ADENOSINETRIPHOSPHATASE, Na + -PHOSPHORYLATION, AND K + -p-NITROPHENYLPHOSPHATASE OF ELECTROPHORUS ELECTRICUS ELECTROPLAX 1 ." Journal of Neurochemistry 31(5): 1231-1237. <http://hdl.handle.net/2027.42/66028>en_US
dc.identifier.issn0022-3042en_US
dc.identifier.issn1471-4159en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/66028
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=212536&dopt=citationen_US
dc.description.abstractZinc ion in micromolar concentrations is an irreversible inhibitor of Electrophorus electricus electroplax microsomal (Na + -K + )-ATPase. The rate of inhibition is dependent on [ZnCl 2 ] and the extent of inhibition varies with the ratio of ZnCl 2 to microsomal protein. The same kinetics are observed for inhibition of K + - p -nitrophenylphosphatase and steady-state levels of Na + -dependent enzyme phosphorylation. The observations suggest that a Zn 2+ -sensitive conformational restraint is important to both kinase and phosphatase activities. The fact that inhibition is irreversible has implications for models seeking to relate zinc effects in tissue to inhibition of (Na + -K + )-ATPase.en_US
dc.format.extent589607 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1978 International Society for Neurochemistryen_US
dc.titleIRREVERSIBLE ZINC ION INHIBITION OF (Na + -K + )-ADENOSINETRIPHOSPHATASE, Na + -PHOSPHORYLATION, AND K + -p-NITROPHENYLPHOSPHATASE OF ELECTROPHORUS ELECTRICUS ELECTROPLAX 1en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumNeurology Research Laboratory. Neurology Department. University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid212536en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/66028/1/j.1471-4159.1978.tb06247.x.pdf
dc.identifier.doi10.1111/j.1471-4159.1978.tb06247.xen_US
dc.identifier.sourceJournal of Neurochemistryen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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