Prevalence of Dementia in Older Latinos: The Influence of Type 2 Diabetes Mellitus, Stroke and Genetic Factors
dc.contributor.author | Haan, Mary N. | en_US |
dc.contributor.author | Mungas, Dan M. | en_US |
dc.contributor.author | Gonzalez, Hector M. | en_US |
dc.contributor.author | Ortiz, Teresa A. | en_US |
dc.contributor.author | Acharya, Ananth | en_US |
dc.contributor.author | Jagust, William J. | en_US |
dc.date.accessioned | 2010-04-01T15:44:46Z | |
dc.date.available | 2010-04-01T15:44:46Z | |
dc.date.issued | 2003-02 | en_US |
dc.identifier.citation | Haan, Mary N.; Mungas, Dan M.; Gonzalez, Hector M.; Ortiz, Teresa A.; Acharya, Ananth; Jagust, William J. (2003). "Prevalence of Dementia in Older Latinos: The Influence of Type 2 Diabetes Mellitus, Stroke and Genetic Factors." Journal of the American Geriatrics Society 51(2): 169-177. <http://hdl.handle.net/2027.42/66237> | en_US |
dc.identifier.issn | 0002-8614 | en_US |
dc.identifier.issn | 1532-5415 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/66237 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12558712&dopt=citation | en_US |
dc.description.abstract | To estimate dementia prevalence in older Mexican Americans, determine the distribution of dementia by etiology, and evaluate the contribution of type 2 diabetes mellitus, stroke, and apolipoprotein E (ApoE) genotype to dementia. DESIGN: Analysis of baseline data from an epidemiological cohort study. SETTING: Sacramento Valley, California. PARTICIPANTS: One thousand seven hundred eighty-nine Latinos aged 60 and older residing in targeted census tracts during 1998–99. MEASUREMENTS: Each subject was interviewed and screened for dementia and cardiovascular risk factors and diseases. Fasting blood samples were drawn for glucose, insulin, and lipids. Buccal cells were obtained for genetic analysis of ApoE. A three-stage process of screening was used to diagnose dementia, including cognitive testing, a clinical examination, and imaging to determine etiology. Presence of dementia was established according to National Institute of Neurological Disorders and Stroke/Alzheimers and Related Disorders Association criteria and California Alzheimer's Disease Diagnostic and Treatment Criteria. RESULTS: Overall dementia prevalence was 4.8%. Prevalence in those aged 85 and older was 31%. Education and Anglo cultural orientation was negatively associated with dementia risk. Risk of dementia was nearly eight times higher in those with both type 2 diabetes mellitus and stroke. Forty-three percent of dementia was attributable to type 2 diabetes mellitus, stroke, or a combination of the two. ApoE allele frequency was E2 5.9%, E3 90.1%, and E4 4%. Those with any E4 and 4–4 combinations had a higher risk for dementia than those with the E3–3 combination. CONCLUSIONS: Dementia prevalence in this ethnic group is similar to that reported in Canadian and European studies but lower than in Caribbean-Hispanics residing in the United States. The etiological fraction of dementia attributable to type 2 diabetes mellitus and stroke is substantial and points toward the need for intervention research and treatment with the goal of reducing neurological sequelae in groups with high prevalence of type 2 diabetes mellitus. The allele frequency of ApoE was similar to that in other published studies on Mexican Americans. The low frequency of the E4 allele may contribute to the difference in etiology of dementia in older Mexican Americans and older people of European background. Dementia in this ethnic group may be related to preventable causes, with a smaller genetic component than in Europeans. | en_US |
dc.format.extent | 111877 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Science Inc | en_US |
dc.rights | 2003 American Geriatrics Society | en_US |
dc.subject.other | Dementia | en_US |
dc.subject.other | Diabetes Mellitus | en_US |
dc.subject.other | Genetics | en_US |
dc.subject.other | Mexican | en_US |
dc.subject.other | Stroke | en_US |
dc.title | Prevalence of Dementia in Older Latinos: The Influence of Type 2 Diabetes Mellitus, Stroke and Genetic Factors | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | * Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan; and | en_US |
dc.contributor.affiliationother | Department of Neurology, University of California at Davis School of Medicine, Davis, California. | en_US |
dc.identifier.pmid | 12558712 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/66237/1/j.1532-5415.2003.51054.x.pdf | |
dc.identifier.doi | 10.1046/j.1532-5415.2003.51054.x | en_US |
dc.identifier.source | Journal of the American Geriatrics Society | en_US |
dc.identifier.citedreference | Graves AB, Larson EB, White LR et al. Opportunities and challenges in international collaborative epidemiologic research of dementia and its subtypes: Studies between Japan and the U.S. Int Psychogeriatr 1994 ; 6 : 209 – 223. | en_US |
dc.identifier.citedreference | Harwood DG, Barker WW, Loewenstein DA et al. A cross-ethnic analysis of risk factors for AD in white Hispanics and white non-Hispanics. Neurology 1999 ; 52 : 551 – 556. | en_US |
dc.identifier.citedreference | Gurland BJ, Wilder DE, Lantigua R et al. Rates of dementia in three ethnoracial groups. J Geriatr Psychiatry 1999 ; 14 : 481 – 493. | en_US |
dc.identifier.citedreference | Acevedo A, Loewenstein DA, Barker WW et al. Category fluency test: Normative data for English- and Spanish-speaking elderly. J Neuropsychol Soc 2000 ; 6 : 760 – 769. | en_US |
dc.identifier.citedreference | Arnold BR, Cuellar I, Guzman N. Statistical and clinical evaluation of the Mattis Dementia Rating Scale—Spanish adaptation: An initial investigation. J Gerontol B Psychol Sci Soc Sci 1998 ; 53B : P364 – P369. | en_US |
dc.identifier.citedreference | Teresi JA, Golden RR, Cross P et al. Item bias in cognitive screening measures. Comparisons of elderly white, Afro-American, Hispanic and high and low education subgroups. J Clin Epidemiol 1995 ; 48 : 473 – 483. | en_US |
dc.identifier.citedreference | 7. American Fact Finder [On-line]. Available at http://factfinder.census.gov Accessed October 2000. | en_US |
dc.identifier.citedreference | 8. Haan MN, GonzÁlez HM. Diversity is good science: The SALSA Study. Aging Health [In press.] | en_US |
dc.identifier.citedreference | Cuellar I, Arnold B, Maldonado R. Acculturation Rating Scale for Mexican Americans. II. A revision of the original ARSMA Scale. Hispanic J Behav Sci 1995 ; 17 : 274 – 304. | en_US |
dc.identifier.citedreference | Katz SC, Ford AB, Moskowitz RW et al. Studies of illness in the aged: The index of ADL, a standardized measure of biological and psychosocial function. JAMA 1963 ; 185 : 914 – 919. | en_US |
dc.identifier.citedreference | Teng EL, Chui HC. The Modified Mini-Mental State (3MS) Examination. J Clin Psychiatry 1987 ; 48 : 314 – 318. | en_US |
dc.identifier.citedreference | GonzÁlez HM, Mungas DM, Reed BR et al. A new verbal learning and memory test for English- and Spanish-speaking older people. J Int Neuropsychol Soc ; 2001 ; 7 : 544 – 555. | en_US |
dc.identifier.citedreference | Mungas D, Marshall SC, Weldon M et al. Age and education correction of Mini-Mental State Examination for English and Spanish-speaking elderly. Neurology 1996 ; 46 : 700 – 706. | en_US |
dc.identifier.citedreference | Mungas D, Reed BR, Marshall SC. Development of psychometrically matched English and Spanish language neuropsychological tests for older persons. Neuropsychology 2000 ; 14 : 209 – 223. | en_US |
dc.identifier.citedreference | Mungas D. Psychometrically matched English and Spanish assessment scales for older persons. Arch Clin Neuropsychol 1999 ; 14 : 712 – 713. | en_US |
dc.identifier.citedreference | Jorm AF, Jacomb PA. Informant questionnaire on cognitive decline in the elderly (IQCODE): Socio-demographic correlates, reliability, validity and some norms. Psychol Med 1989 ; 19 : 1015 – 1022. | en_US |
dc.identifier.citedreference | Jorm AF, Scott R, Cullen JS et al. Performance of the informant questionnaires on cognitive decline in the elderly (IQCODE) as a screening test for dementia. Psychol Med 1991 ; 21 : 785 – 790. | en_US |
dc.identifier.citedreference | Morales JM. The screening of mild dementia with a shortened Spanish version of the IQCODE. Alzheimer Dis Assoc Dis 1995 ; 9 : 105 – 111. | en_US |
dc.identifier.citedreference | Knopman DS, DeKosky ST, Cummings JL et al. Practice parameters: Diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2002 ; 56 : 1143 – 1153. | en_US |
dc.identifier.citedreference | Chui HC, Victoroff JJ, Margolin DI et al. Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer disease diagnostic and treatment centers. Neurology 1992 ; 42 : 473 – 480. | en_US |
dc.identifier.citedreference | Tierney MC, Black SE, Szalai JP et al. Recognition memory and verbal fluency differentiate probable Alzheimer dementia from subcortical ischemic vascular dementia. Arch Neurol 2001 ; 58 : 1654 – 1659. | en_US |
dc.identifier.citedreference | McKhann G, Drachman D, Folstein M et al. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984 ; 34 : 939 – 944. | en_US |
dc.identifier.citedreference | Appel E, Eisenberg S, Roitelman J. Improved PCR amplification/Hhal restriction for unambiguous determination of apolipoprotein E alleles. Clin Chem 1995 ; 41 : 187 – 190. | en_US |
dc.identifier.citedreference | Sackett DL. Clinical Epidemiology: A Basic Science for Clinical Medicine. Boston : Little, Brown, 1991. | en_US |
dc.identifier.citedreference | Hendrie HC, Ogunniyi A, Hall KS et al. Incidence of dementia and Alzheimer disease in 2 communities. JAMA 2001 ; 285 : 739 – 747. | en_US |
dc.identifier.citedreference | Fleiss JL. Statistical Methods for Rates and Proportions. New York : John Wiley & Sons, 1981. | en_US |
dc.identifier.citedreference | Lobo A, Launer LJ, Fratiglioni L et al. Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 2000 ; 54 : S4 – S9. | en_US |
dc.identifier.citedreference | 28. Canadian study of health and aging: Study methods and prevalence of dementia. Can Med Assoc J 1994;150:899–913. | en_US |
dc.identifier.citedreference | Ganguli M, Belle S, Ratcliff G et al. Sensitivity and specificity for dementia of population-based criteria for cognitive impairment: The MoVIES project. J Gerontol 1993 ; 48 : M152 – M161. | en_US |
dc.identifier.citedreference | Kraemer HC. Adjusting Mini Mental State Examination scores for age and educational level to screen for dementia: Correcting bias or reducing validity? Int Psychogeriatr 1998 ; 10 : 43 – 51. | en_US |
dc.identifier.citedreference | 31. Centers for Disease Control and Prevention. Advance Data, April 2000 [On-line]. Available at http://www.cdc.gov/nchs/about/major/nnhsd/nnhslist.htm Accessed October 30, 2002. | en_US |
dc.identifier.citedreference | Magaziner J, German P, Zimmerman SI et al. The prevalence of dementia in a statewide sample of new nursing home admissions aged 65 and older: Diagnosis by expert panel. Epidemiology of Dementia in Nursing Homes Research Group. Gerontologist 2000 ; 40 : 663 – 672. | en_US |
dc.identifier.citedreference | Gamboa R, Hernandez-Pacheco G, Hesiquio R et al. Apolipoprotein E polymorphism in the Indian and Mestizo populations of Mexico. Hum Biol 2000 ; 72 : 975 – 981. | en_US |
dc.identifier.citedreference | Kamboh MI, Crawford MH, Aston CE et al. Population distributions of APOE, APOH, and APOA4 polymorphisms and their relationships with quantitative plasma lipid levels among the Evenki herders of Siberia. Hum Biol 1996 ; 68 : 231 – 243. | en_US |
dc.identifier.citedreference | Haan MN, Shemanski L, Jagust WJ et al. The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons. JAMA 1999 ; 282 : 40 – 46. | en_US |
dc.identifier.citedreference | Slooter AJ, Tang MX, van Duijn CM et al. Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation. JAMA 1997 ; 277 : 818 – 821. | en_US |
dc.identifier.citedreference | Haffner SM, Stern MP, Miettinen H et al. Apolipoprotein E polymorphism and LDL size in a biethnic population. Arterioscler Thromb Vasc Biol 1996 ; 16 : 1184 – 1188. | en_US |
dc.identifier.citedreference | Shriver MD, Boerwinkle E, Hewett-Emmett D et al. Frequency and effects of apolipoprotein E polymorphism in Mexican-American NIDDM subjects. Diabetes 1991 ; 40 : 334 – 337. | en_US |
dc.identifier.citedreference | Valdez R, Howard BV, Stern MP et al. Apolipoprotein E polymorphism and insulin levels in a biethnic population. Diabetes Care 1995 ; 18 : 992 – 1000. | en_US |
dc.identifier.citedreference | Harris MI. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults: The Third National Health and Nutrition Examination Survey (NHANES), 1988–94. Diabetes Care 1998 ; 21 : 518 – 524. | en_US |
dc.identifier.citedreference | Flegal KM. Prevalence of diabetes in Mexican Americans, Cubans, and Puerto Ricans from the Hispanic Health and Examination Survey (HHANES), 1982–84. Diabetes Care 1991 ; 14 : 628 – 638. | en_US |
dc.identifier.citedreference | Flegal KM, Ezzati TM, Harris MI et al. Prevalence of diabetes in Mexican Americans, Cubans, and Puerto Ricans from the Hispanic Health and Nutrition Examination Survey, 1982–84. Diabetes 1991 ; 14 : 628 – 638. | en_US |
dc.identifier.citedreference | 43. U.S. Census Bureau. Population by age, Hispanic origin and race, and Sex: March, 1999 [On-line]. Current Population Survey Internet release, Available at http://www.census.gov/ Accessed March 8, 2000. | en_US |
dc.identifier.citedreference | Kaplan GA, Turrell G, Lynch JW et al. Childhood socioeconomic position and cognitive function in adulthood. Int J Epidemiol 2001 ; 30 : 256 – 263. | en_US |
dc.identifier.citedreference | Launer LJ, Andersen K, Dewey ME et al. Rates and risk factors for dementia and Alzheimer's disease: Results from EURODEM pooled analyses. EURODEM Incidence Research Group and Work Groups. European Studies of Dementia. Neurol 1999 ; 52 : 78 – 84. | en_US |
dc.identifier.citedreference | Lindsay J, Hebert R, Rockwood K. The Canadian Study of Health and Aging: Risk factors for vascular dementia. Stroke 1997 ; 28 : 526 – 530. | en_US |
dc.identifier.citedreference | Graves AB, Rajaram L, Bowen JD et al. Cognitive decline and Japanese culture in a cohort of older Japanese Americans in King County, WA: The Kame Project. J Gerontol B Psychol Sci Soc Sci 1999 ; 54B : S154 – S161. | en_US |
dc.identifier.citedreference | Gutierrez DG. Migration, emergent ethnicity and the ‘Third Space’: The shifting politics of nationalism in greater Mexico. J Am History 1999 ; 86 : 481 – 517. | en_US |
dc.identifier.citedreference | Copeland JR, McCracken CF, Dewey ME et al. Undifferentiated dementia, Alzheimer's disease and vascular dementia: Age and gender-related incidence in Liverpool. The MRC-ALPHA Study. Br J Psychiatry 1999 ; 175 : 433 – 438. | en_US |
dc.identifier.citedreference | Fratiglioni L, Viitanen M, von Strauss E et al. Very old women at highest risk of dementia and Alzheimer's disease: Incidence data from the Kungsholmen Project, Stockholm. Neurology 1997 ; 48 : 132 – 138. | en_US |
dc.identifier.citedreference | Zhang MY, Katzman R, Salmon D et al. The prevalence of dementia and Alzheimer's disease in Shanghai, China. Impact of age, gender, and education. Ann Neurol 1990 ; 27 : 428 – 437. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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