View Item 

Show simple item record

Bkm sequences from the human X chromosome contain large clusters of GATA/GACA repeats

dc.contributor.authorErickson, Robert P.en_US
dc.contributor.authorRoss, C. E.en_US
dc.contributor.authorGorski, Jerome L.en_US
dc.contributor.authorStalvey, John R. D.en_US
dc.contributor.authorDrumm, M. M.en_US
dc.date.accessioned2010-04-01T15:54:18Z
dc.date.available2010-04-01T15:54:18Z
dc.date.issued1988-07en_US
dc.identifier.citationERICKSON, R. P.; ROSS, C. E.; GORSKI, J. L.; STALVEY, J. R. D.; DRUMM, M. M. (1988). "Bkm sequences from the human X chromosome contain large clusters of GATA/GACA repeats." Annals of Human Genetics 52(3): 167-176. <http://hdl.handle.net/2027.42/66402>en_US
dc.identifier.issn0003-4800en_US
dc.identifier.issn1469-1809en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/66402
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3250328&dopt=citationen_US
dc.description.abstractIn order to determine whether the regional localizations of Bkm repeats detected on the human X chromosome consisted of typical GATA/GACA repeats, clones were isolated, mapped, and sequenced. Nine Bkm-hybridizing clones from Kunkel's fluorescent-activated, cell-sorted X-chromosome library were all unique. Five were mapped in detail with restriction enzymes and the Bkm-hybridizing segments were localized. Confirmation of X chromosomal homology was obtained for 2 of the clones and Bkm segments from these 2 clones were sequenced. Seventeen contiguous GATA repeats were found in each clone and the overall repeat arrangement showed relatively few differences from previously sequenced Bkm sequences. These are the first sequences of human Bkm repeats. The results, when compared with previously published results, suggest that there may be significant differences between the organization of Bkm repeats on the human X and on the human Y chromosome.en_US
dc.format.extent681076 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1988 University College London and Blackwell Publishing Ltden_US
dc.titleBkm sequences from the human X chromosome contain large clusters of GATA/GACA repeatsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum*Departments of Human Genetics, University of Michigan School of Medicine, Ann Arbor, Michigan 48109-0618en_US
dc.contributor.affiliationum†Departments of Pediatrics and Communicable Diseases, University of Michigan School of Medicine, Ann Arbor, Michigan 48109-0618en_US
dc.identifier.pmid3250328en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/66402/1/j.1469-1809.1988.tb01094.x.pdf
dc.identifier.doi10.1111/j.1469-1809.1988.tb01094.xen_US
dc.identifier.sourceAnnals of Human Geneticsen_US
dc.identifier.citedreferenceArnemann, J., Jakubiczka, S., Schmidtke, J., SchÄfer, R., Epplen, J. T. ( 1986 ). Clustered GATA repeats (Bkm sequences) on the human Y chromosome. Hum. Genet. 73, 301 – 303.en_US
dc.identifier.citedreferenceEpplen, J. T., Cellini, A., Romero, S., Ohno, S. ( 1983 ). An attempt to approach the molecular mechanisms of primary sex determination: W- and Y-chromosomal conserved simple repetitive DNA sequences and their differential expression in mRNA. J. Exp. Zool. 228, 305 – 312.en_US
dc.identifier.citedreferenceEpplen, J. T., McCarrey, J. R., Sutou, S., Ohno, S. ( 1982 ). Base sequence of a cloned snake W-chromosome DNA fragment and identification of a male-specific putative mRNA in the mouse. Proc. Natn. Acad. Sci. USA 79, 3798 – 3802.en_US
dc.identifier.citedreferenceErickson, R. P., Bevilacqua, A., Ross, C., Donaldson, S., Stalvey, J. R. D. ( 1987 ). Do Bkm sequences play a role in human sex determination ? In Genetic Markers of Sex Differentiation ( ed. F. P. Haseltine, M. E. McClure and E. H. Goldberg ), pp. 149 – 159. New York : Plenum Press.en_US
dc.identifier.citedreferenceEvans, E. P., Burtenshaw, M. D., Cattanach, B. M. ( 1982 ). Meiotic crossing over between the X and Y chromosomes of male mice carrying the sex-reversing ( Sxr ) factor. Nature 300, 443 – 445.en_US
dc.identifier.citedreferenceFeinberg, A. P., Vogelstein, B. ( 1984 ). Addendum: A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 137, 266 – 267.en_US
dc.identifier.citedreferenceGoodfellow, P. N. ( 1975 ). Genetics and biochemistry of tissue antigens. D. Phil. Thesis, Oxford University.en_US
dc.identifier.citedreferenceJones, K. W., Singh, L. ( 1981 ). Conserved repeated DNA sequences in vertebrate sex chromosomes. Hum. Genet. 58, 46 – 53.en_US
dc.identifier.citedreferenceKiel-Metzger, K., Warren, G., Wilson, G. N., Erickson, R. P. ( 1985 ). Evidence that the human Y chromosome does not contain clustered DNA sequences (Bkm) associated with heterogametic sex determination in other vertebrates. N. Engl. J. Med. 313, 242 – 245.en_US
dc.identifier.citedreferenceKunkel, L. M., Tantraraki, U., Eisenhard, M., Latt, S. A. ( 1982 ). Regional localization on the human X of DNA segments cloned from flow sorted chromosomes. Nucleic Acids Res. 10, 1557 – 1578.en_US
dc.identifier.citedreferenceLevinson, G., Marsh, J. L., Epplen, J. T., Gutman, G. A. ( 1985 ). Cross-hybridizing snake satellite, Drosophila, and mouse DNA sequences may have arisen independently. Mol. Biol. Evol. 2, 494 – 504.en_US
dc.identifier.citedreferenceLitt, M., White, R. L. ( 1985 ). A highly polymorphic locus in human DNA revealed by cosmid-derived probes. Proc. Natn. Acad. Sci. USA 82, 6206 – 6210.en_US
dc.identifier.citedreferenceNabholz, M., Miggiano, V., Bodmer, W. F. ( 1969 ). Genetic analysis with human-mouse somatic cell hybrids. Nature 223, 358 – 363.en_US
dc.identifier.citedreferencePlatt, T. H. K., Dewey, M. J. ( 1987 ) Multiple forms of male specific simple repetitive sequences in the genus Mus. J. Mol. Evol. 25, 201 – 206.en_US
dc.identifier.citedreferenceSanger, F., Nicklen, S., Coulson, A. R. ( 1977 ). DNA sequencing with chain-terminating inhibitors. Proc. Natn. Acad. Sci. USA 74, 5463 – 5467.en_US
dc.identifier.citedreferenceShapiro, M., Erickson, R. P., Lewis, S., Tres, L. L. ( 1982 ). Serological and cytological evidence for increased Y-chromosome related material in Sxr, XY (sex-reversed carrier, male) mice. J. Reprod. Immunol. 4, 191 – 206.en_US
dc.identifier.citedreferenceSingh, L., Jones, K. W. ( 1982 ). Sex reversal in the mouse Mus musculus is caused by a recurrent nonreciprocal crossover involving the X and an aberrant Y chromosome. Cell 28, 205 – 216.en_US
dc.identifier.citedreferenceSingh, L., Jones, K. W. ( 1986 ). Bkm sequences are polymorphic in humans and are clustered in pericentric regions of various acrocentric chromosomes including the Y. Hum. Genet. 73, 304 – 308.en_US
dc.identifier.citedreferenceSingh, L., Phillips, C., Jones, K. W. ( 1984 ). The conserved nucleotide sequences of Bkm, which define Sxr in the mouse, are transcribed. Cell 36, 111 – 120.en_US
dc.identifier.citedreferenceSingh, L., Purdom, I. F., Jones, K. W. ( 1976 ). Satellite DNA and evolution of sex chromosomes. Chromosoma 59, 43 – 62.en_US
dc.identifier.citedreferenceSingh, L., Purdom, I. F., Jones, K. W. ( 1980a ). Sex chromosome associated satellite DNA: evolution and conservation. Chromosoma 79, 137 – 157.en_US
dc.identifier.citedreferenceSingh, L., Purdom, I. F., Jones, K. W. ( 1980b ). Conserved sex-chromosome-associated nucleotide sequences in eukaryotes. Quant. Biol. Cold Spring Harbor Symp. 45 ( pt. 2 ), 805 – 814.en_US
dc.identifier.citedreferenceSouthern, E. ( 1975 ). Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98, 503.en_US
dc.identifier.citedreferenceTaber, S., Richardson, C. C. ( 1987 ). DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. Proc. Natn. Acad. Sci. USA 94, 4767 – 4771.en_US
dc.identifier.citedreferenceTraut, W. ( 1987 ). Hypervariable Bkm DNA loci in a moth, Ephestia kuehniella : Does transposition cause restriction fragment length polymorphism ? Genetics 115, 493 – 498.en_US
dc.identifier.citedreferenceWolfe, J., Erickson, R. P., Rigby, P. W. J., Goodfellow, P. N. ( 1984 ). Cosmid clones derived from both euchromatic and heterochromatic regions of the human Y chromosome. EM BO J. 3, 1997 – 2003.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
j.1469-1809.1988.tb01094.x.pdf
Size:
665.1KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.