Effects of Vagus Nerve Stimulation on Sleep-related Breathing in Epilepsy Patients
dc.contributor.author | Marzec, Mary L. | en_US |
dc.contributor.author | Edwards, Jonathan | en_US |
dc.contributor.author | Sagher, Oren | en_US |
dc.contributor.author | Fromes, Gail | en_US |
dc.contributor.author | Malow, Beth A. | en_US |
dc.date.accessioned | 2010-04-01T15:56:54Z | |
dc.date.available | 2010-04-01T15:56:54Z | |
dc.date.issued | 2003-07 | en_US |
dc.identifier.citation | Marzec, Mary; Edwards, Jonathan; Sagher, Oren; Fromes, Gail; Malow, Beth A. (2003). "Effects of Vagus Nerve Stimulation on Sleep-related Breathing in Epilepsy Patients." Epilepsia 44(7): 930-935. <http://hdl.handle.net/2027.42/66447> | en_US |
dc.identifier.issn | 0013-9580 | en_US |
dc.identifier.issn | 1528-1167 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/66447 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12823576&dopt=citation | en_US |
dc.description.abstract | Purpose: To describe the effects of vagus nerve stimulation (VNS) on sleep-related breathing in a sample of 16 epilepsy patients. Methods: Sixteen adults with medically refractory epilepsy (nine men, seven women, ages 21–58 years) underwent baseline polysomnograms (PSGs). Three months after VNS therapy was initiated, PSGs were repeated. In addition, patient 7 had a study with esophageal pressure monitoring, and patient 1 had a continuous positive airway pressure (CPAP) trial. Results: Baseline PSGs: One of 16 patients had an apnea–hypopnea index (AHI) >5 (6.8). Treatment PSGs: Five of 16 patients had treatment AHIs >5. Respiratory events were more frequent during periods with VNS activation (on-time) than without VNS activation (off-time; p = 0.016 ). Follow-up studies: Esophageal pressure monitoring in patient 7 showed crescendos in esophageal pressure during VNS activation, supporting an obstructive pattern. The CPAP trial of patient 1 showed that all respiratory events were associated with VNS stimulation at low CPAP levels. They were resolved at higher CPAP levels. Conclusions: Treatment with VNS affects respiration during sleep and should be used with care, particularly in patients with preexisting obstructive sleep apnea. The AHI after VNS treatment remained <5 in the majority of patients and was only mildly elevated (<12) in five patients. In one patient, CPAP resolved VNS-related respiratory events. | en_US |
dc.format.extent | 124110 bytes | |
dc.format.extent | 3110 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Science Inc | en_US |
dc.rights | 2003 International League Against Epilepsy | en_US |
dc.subject.other | Epilepsy | en_US |
dc.subject.other | Vagus Nerve Stimulator | en_US |
dc.subject.other | Obstructive Sleep Apnea. | en_US |
dc.title | Effects of Vagus Nerve Stimulation on Sleep-related Breathing in Epilepsy Patients | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Michael S. Aldrich Sleep Disorders Laboratory and the Epilepsy Program, Clinical Neurophysiology Section, Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 12823576 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/66447/1/j.1528-1157.2003.56202.x.pdf | |
dc.identifier.doi | 10.1046/j.1528-1157.2003.56202.x | en_US |
dc.identifier.source | Epilepsia | en_US |
dc.identifier.citedreference | Schachter S, Saper C. Vagus nerve stimulation. Epilepsia 1998 ; 39 : 677 – 86. | en_US |
dc.identifier.citedreference | Malow BA, Edwards J, Marzec M, et al. Effects of vagus nerve stimulation on respiration during sleep: a pilot study. Neurology 2000 ; 55 : 1450 – 4. | en_US |
dc.identifier.citedreference | Murray BJ, Matheson JK, Scammell TE. Effects of vagus nerve stimulation on respiration during sleep. Neurology 2001 ; 57 : 1523 – 4. | en_US |
dc.identifier.citedreference | Deochand MC, Quint SR, Bernard EJ, et al. Sleep related respiratory function during vagal nerve stimulation. Epilepsia 2000 ; 41 : 204. | en_US |
dc.identifier.citedreference | Sorenson PG, Ferber RA. The effects of vagal nerve stimulation on respiration during sleep in pediatric patients with epilepsy. Sleep 2002 ; 25 : A163 – 4. | en_US |
dc.identifier.citedreference | Malow BA, Edwards J, Marzec M, et al. Vagus nerve stimulation reduces daytime sleepiness in epilepsy patients. Neurology 2001 ; 57 : 879 – 84. | en_US |
dc.identifier.citedreference | 7. Cyberonics. Physician's manual for the neurocybernetic prosthesis (NCP) system pulse generator models 100 and 101. Houston : Cyberonics, 2000. | en_US |
dc.identifier.citedreference | 8. American Sleep Disorders Association. EEG arousals: scoring rules and examples: EEG arousals: scoring rules and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep 1992 ; 15 : 173 – 84. | en_US |
dc.identifier.citedreference | Strollo PJ, Rogers RM. Obstructive sleep apnea. N Engl J Med 1996 ; 334 : 99 – 104. | en_US |
dc.identifier.citedreference | Garrigue S, Bordier P, JaÏs P, et al. Benefit of atrial pacing in sleep apnea syndrome. N Engl J Med 2002 ; 346 : 404 – 12. | en_US |
dc.identifier.citedreference | Dinesen H, Gram L, Anderson T, et al. Weight gain during treatment with valproate. Acta Neurol Scand 1984 ; 70 : 65 – 9. | en_US |
dc.identifier.citedreference | Robinson R, Zwillich C. Drugs and sleep respiration. In : Kryger M, Roth T, Dement W, eds. Principles and practice of sleep medicine. Philadelphia : WB Saunders, 1994 : 603 – 20. | en_US |
dc.identifier.citedreference | Devinsky O, Ehrenberg B, Barthlen GM, et al. Epilepsy and sleep apnea syndrome. Neurology 1994 ; 44 : 2060 – 4. | en_US |
dc.identifier.citedreference | Vaughn BV, D'Cruz OF, Beach R, et al. Improvement of epileptic seizure control with treatment of obstructive sleep apnoea. Seizure 1996 ; 5 : 73 – 8. | en_US |
dc.identifier.citedreference | Malow BA, Fromes GA, Aldrich MS. Usefulness of polysomnography in epilepsy patients. Neurology 1997 ; 48 : 1389 – 94. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.