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A New Biological Approach To Vital Pulp Therapy

dc.contributor.authorRutherford, Bruceen_US
dc.contributor.authorFitzgerald, Marken_US
dc.date.accessioned2010-04-13T19:01:20Z
dc.date.available2010-04-13T19:01:20Z
dc.date.issued1995en_US
dc.identifier.citationRutherford, Bruce; Fitzgerald, Mark (1995). "A New Biological Approach To Vital Pulp Therapy." Critical Reviews in Oral Biology & Medicine 3(6): 218-229. <http://hdl.handle.net/2027.42/66969>en_US
dc.identifier.issn1045-4411en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/66969
dc.description.abstractMolecular biology is providing opportunities to develop new strategies or agents for the treatment of a wide variety of diseases. The availability of large amounts of highly purified proteins produced by recombinant DNA techniques is an obvious example. Recent evidence has implicated proteins belonging to the bone morphogenetic protein (BMP) subgroup of the transforming growth factor beta supergene family in tooth formation and dentinogenesis. It has long been known that bone and dentin contain bone morphogenetic protein activity. Recently, recombinant human BMP-2, -4, and -7 (also known as OP-1 ) have been shown to induce reparative dentin formation in experimental models of large direct pulp exposures in permanent teeth. The manner in which these agents act appears unique. New reparative dentin replaces the stimulating agents applied directly to the partially amputated pulp. Hence, the new tissue forms contiguous with, largely superficial to, and not at the expense of the remaining vital pulp tissue. This suggests a therapeutic approach permitting the induction of a predetermined and controlled amount of reparative dentin. Additionally, OP-l has been associated with the formation of reparative dentin after application to a freshly cut but intact layer of dentin. These findings may provide future clinicians with additional options for the treatment of substantially damaged or diseased vital teeth.en_US
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dc.publisherSAGE Publicationsen_US
dc.subject.otherBone Morphogenetic Proteinsen_US
dc.subject.otherReparative Dentinen_US
dc.subject.otherReactionary Dentinen_US
dc.subject.otherOdontoblast Differentiation.en_US
dc.titleA New Biological Approach To Vital Pulp Therapyen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelDentistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan School of Dentistry, 1011 N.University, Ann Arbor, Ml 48109-1078en_US
dc.contributor.affiliationumUniversity of Michigan School of Dentistry, 1011 N.University, Ann Arbor, Ml 48109-1078en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/66969/2/10.1177_10454411950060030401.pdf
dc.identifier.doi10.1177/10454411950060030401en_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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