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Absence of Expression of c-sis and Transforming Growth Factor-β mRNA in Malignant Fibrous Histiocytoma

dc.contributor.authorFrank, Thomas S.en_US
dc.contributor.authorReed, John C.en_US
dc.contributor.authorBrooks, John S. J.en_US
dc.date.accessioned2010-04-13T19:26:46Z
dc.date.available2010-04-13T19:26:46Z
dc.date.issued1993en_US
dc.identifier.citationFrank, Thomas; Reed, John; Brooks, John S. J. (1993). "Absence of Expression of c-sis and Transforming Growth Factor-β mRNA in Malignant Fibrous Histiocytoma." International Journal of Surgical Pathology 1(2): 117-121. <http://hdl.handle.net/2027.42/67413>en_US
dc.identifier.issn1066-8969en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/67413
dc.description.abstractTotal RNA was extracted from five malignant fibrous histiocytomas and two benign fibrohistiocytic lesions and assayed for mRNA expressions for transforming growth factor beta (TGF-β) and c-sis by Northern blot analysis. Production of both of these has been associated with cells of monocyte-macrophage lineage, and these factors have been shown to be important in physiologic mesenchymal cell proliferation. No mRNA expression of either TGF-β or c-sis was identified in any of the fibrohistiocytic tumor samples. The lack of expression of TGF-β and c-sis may be consistent with a nonhistiocytic origin of malignant fibrous histiocytoma, or may reflect transformation- associated loss of the normal molecular mechanisms of mesenchymal proliferation. The absence of c-sis mRNA expression can be reconciled with the prior immunohisto chemical demonstration of platelet-derived growth factor in tumor cells of malignant fibrous histiocytoma. Int J Surg Pathol(2):117-122, 1993en_US
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dc.format.extent496208 bytes
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dc.publisherSage Publicationsen_US
dc.subject.otherMalignant Fibrous Histiocytomaen_US
dc.subject.otherC-sisen_US
dc.subject.otherTransforming Growth Factor Betaen_US
dc.subject.otherMRNA.en_US
dc.titleAbsence of Expression of c-sis and Transforming Growth Factor-β mRNA in Malignant Fibrous Histiocytomaen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPathologyen_US
dc.subject.hlbsecondlevelSurgery and Anesthesiologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan,en_US
dc.contributor.affiliationotherDepartment of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.en_US
dc.contributor.affiliationotherDepartment of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/67413/2/10.1177_106689699300100205.pdf
dc.identifier.doi10.1177/106689699300100205en_US
dc.identifier.sourceInternational Journal of Surgical Pathologyen_US
dc.identifier.citedreferenceSporn MB, Roberts AB The transforming growth factor-betas: past, present, and future. Ann N Y Acad Sci 593:1-6, 1990en_US
dc.identifier.citedreferenceAssoian RK, Fleurdelys BE, Stevenson HC et al. Expression and secretion of type beta transforming growth factor by activated human macrophages. Proc Natl Acad Sci U S A 84:6020-6024, 1987en_US
dc.identifier.citedreferenceWahl SM, Mc Cartney Francis N., Allen JB et al. Macrophage production of TGF-beta and regulation by TGF-beta. Ann N Y Acad Sci 593:188-196, 1990en_US
dc.identifier.citedreferenceLeof EB, Proper JA, Goustin AS Induction of c-sis m RNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity. Proc Natl Acad Sci U S A 83: 2453-2457, 1986en_US
dc.identifier.citedreferenceRoberts AB, Thompson NL, Heine U. et al. Transforming growth factor-beta: Possible roles in carcinogenesis. Br J Cancer 57:594-600, 1988en_US
dc.identifier.citedreferenceWahl SM, Wong H., Mc Cartney Francis N. Role of growth factors in inflammation and repair. J Cell Biochem 40:193-199, 1989en_US
dc.identifier.citedreferenceRaghu G., Masta S., Meyers D. et al. Collagen synthesis by normal and fibrotic human lung fibroblasts and the effect of transforming growth factor-beta. Am Rev Respir Dis 140:95-100, 1989en_US
dc.identifier.citedreferenceJohnsson A., Heldin C-H., Wasteson Å. et al. The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor. EMBO J 3:921-928, 1984en_US
dc.identifier.citedreferenceDeuel TF, Silverman NJ, Kawahara RS Platelet-derived growth factor: A multifunctional regulator of normal and abnormal cell growth. Biofactors 1: 213-217, 1988en_US
dc.identifier.citedreferenceMartinet Y., Bitterman PB, Mornex J-F. et al. Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity. Nature 319:158-160, 1991en_US
dc.identifier.citedreferenceMornex J-F., Martinet Y., Yamauchi K. et al. Spontaneous expression of the c-sis gene and release of a platelet-derived growth factorlike molecule by human alveolar macrophages. J Clin Invest 78: 61-66, 1986en_US
dc.identifier.citedreferenceShimokado K., Raines EW, Madtes DK et al. A significant part of macrophage-derived growth factor consists of at least two forms of PDGF. Cell 43: 277-286, 1985en_US
dc.identifier.citedreferenceChomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem 162: 156-159,1987en_US
dc.identifier.citedreferenceAlbelda SM, Elias JA, Levine EM et al. Endotoxin stimulates platelet-derived growth factor production from cultured human pulmonary endothelial cells. Am J Physiol 257:L65-L70, 1989en_US
dc.identifier.citedreferenceMc Master GK, Carmichael GG Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. Proc Natl Acad Sci U S A 74:4835, 1977en_US
dc.identifier.citedreferenceSambrook J., Fritsch EF, Maniatis T. Molecular cloning: A laboratory manual. 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989en_US
dc.identifier.citedreferenceFeinberg AP, Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132:6-13, 1983en_US
dc.identifier.citedreferenceDalla Favera R, Gallo RC, Giallongo A. Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene. Science 218: 686-688, 1982en_US
dc.identifier.citedreferenceDerynck R., Jarrett JA, Chen EY et al. Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature 316:701-705, 1985en_US
dc.identifier.citedreferenceSuggs SV, Wallace RB, Hirose T. et al. Use of synthetic oligonucleotides as hybridization probes: isolation of cloned c DNA sequences for human beta 2-micro-globulin. Proc Natl Acad Sci U S A 78:6613-6617, 1981en_US
dc.identifier.citedreferenceGraves DT, Owen AJ, Barth RK et al. Detection of c-sis transcripts and synthesis of PDGF-like proteins by human osteosarcoma cells. Science 226: 972-974, 1984en_US
dc.identifier.citedreferenceMadisen L., Webb NR, Rose TM et al. Transforming growth factor-beta2: c DNA cloning and sequence analysis. DNA 7:1-8, 1988en_US
dc.identifier.citedreferenceDerynck R., Goedel DV, Ulrich A. et al. Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epithermal growth factor receptor by human tumors. Cancer Res 47:707, 1987en_US
dc.identifier.citedreferenceEva A., Robbins KC, Andersen PR et al. Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells. Nature 295:116, 1982en_US
dc.identifier.citedreferenceFahrer C., Brachmann R., von der Helm K. Expression of c-sis and other cellular proto-oncogenes in human sarcoma cell lines and biopsies. Int J Cancer 44:652-657, 1989en_US
dc.identifier.citedreferenceOzello L., Stout AP, Murray MR Cultural characteristics of malignant histiocytomas and fibrous xanthomas. Cancer 16:331-344, 1963en_US
dc.identifier.citedreferenceTaxy JB, Battifora H.: Malignant fibrous histiocytoma: An electron microscopic study. Cancer 40: 254-267, 1977en_US
dc.identifier.citedreferenceRoholl PJ, Kleyne J., Van Blokland M et al. Characterization of two cell lines, derived from two malignant fibrous histiocytomas. J Pathol 150:103-112, 1986en_US
dc.identifier.citedreferenceBrecher ME, Franklin WA: Absence of mononuclear phagocyte antigens in malignant fibrous histiocytoma. Am J Clin Pathol 86:344-348, 1986en_US
dc.identifier.citedreferenceWood GS, Beckstead JH, Turner RR et al. Malignant fibrous histiocytoma tumor cells resemble fibroblasts. Am J Surg Pathol 10:323-335, 1986en_US
dc.identifier.citedreferenceRoholl PJ, Kleyne J., Elbers H. et al. Characterization of tumour cells in malignant fibrous histiocytomas and other soft tissue tumours in comparison with malignant histiocytes. I. Immunohistochemical study on paraffin sections. J Pathol 147:87-95, 1985en_US
dc.identifier.citedreferenceRoholl PJ, Kleyne J., Van Unnik JA Characterization of tumor cells in malignant fibrous histiocytomas and other soft-tissue tumors, in comparison with malignant histiocytes. II. Immunoperoxidase study on cryostat sections. Am J Pathol 121:269-274, 1985en_US
dc.identifier.citedreferenceRoholl PJ, Kleyne J., van Basten CD et al. A study to analyze the origin of tumor cells in malignant fibrous histiocytomas. A multiparametric characterization. Cancer 56:2809-2815, 1985en_US
dc.identifier.citedreferencede Boulay CE. Demonstration of alpha-1-antitrypsin and alpha-1-antichymotrypsin in fibrous histiocytomas using the immunoperoxidase technique. Am J Surg Pathol 6:559-564, 1982en_US
dc.identifier.citedreferenceStrauchen JA, Dimitriu Bona A. Malignant fibrous histiocytoma: Expression of monocyte/macrophage differentiation antigens detected with monoclonal antibodies. Am J Pathol 124:303-309, 1986en_US
dc.identifier.citedreferenceIwasaki H., Kikuchi M., Takii M. et al. Benign and malignant fibrous histiocytomas of the soft tissues: Functional characterization of the cultured cells. Cancer 50:520-530, 1982en_US
dc.identifier.citedreferenceKindblom LG, Jacobsen GK, Jacobsen M. Immunohistochemical investigations of tumors of supposed fibroblastic-histiocytic origin. Hum Pathol 13: 834-840, 1982en_US
dc.identifier.citedreferenceTanaka H., Mori Y., Akedo H. Histiocytic differentiation of mouse malignant fibrous histiocytoma-like tumor cells by culturing with sodium butyrate. Cell Biol Int Rep 6:85-89, 1982en_US
dc.identifier.citedreferencePerosio PM, Brooks Jsj. Expression of growth factors and growth factor receptors in soft tissue tumors: Implications for the autocrine hypothesis. Lab Invest 60:245-253, 1989en_US
dc.identifier.citedreferenceSoini Y., Miettinen M. Alpha-1-antitrypsin and lysozyme: Their limited significance in fibrohistiocytic tumors. Am J Clin Pathol 91:515-521, 1989en_US
dc.identifier.citedreferenceBrooks Jsj. Immunohistochemistry of soft tissue tumors: progress and prospects. Hum Pathol 13: 969-974, 1982en_US
dc.identifier.citedreferenceLeveen P., Claesson Welsh L, Heldin C-H. et al. Expression of messenger RNAs for platelet-derived growth factor and its receptors in human sarcoma cell lines. Int J Cancer 46:1066-1070, 1990en_US
dc.identifier.citedreferenceHeldin C-H., Johnsson A., Wennergren S. et al. A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains. Nature 319:511-514, 1986en_US
dc.identifier.citedreferenceBetsholtz C., Johnsson A., Heldin C-H. et al. c DNA-sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature 320: 695-699, 1986en_US
dc.identifier.citedreferencePaulsson Y., Hammacher A., Heldin C-H. et al. Possible positive autocrine feedback in the prereplicative phase of human fibroblasts. Nature 328:715-717, 1987en_US
dc.identifier.citedreferenceFranklin WA, Christison WH, Colley M. et al. In situ distribution of the beta-subunit of platelet-derived growth factor receptor in nonneoplastic tissue and in soft tissue tumors. Cancer Res 50:6344-6348, 1990en_US
dc.identifier.citedreferencePalman C., Bowen-Pope DF, Brooks SJ Platelet-derived growth factor receptor expression in soft tissue tumors. Lab Invest 62:77A, 1990 (Abstract)en_US
dc.identifier.citedreferencePalman C., Bowen-Pope DF, Brooks SJ Platelet-derived growth factor receptor (β-subunit) immunoreactivity in soft tissue tumors. Lab Invest 66: 108-115, 1992en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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