Cydophosphamide-Induced Abnormalities in the Incisors of the Rat

Lee Vahlsing, H.; Kim, Sun-Kee; Feringa, Earl

1977

Citation: Lee Vahlsing, H.; Kim, Sun-Kee; Feringa, Earl (1977). "Cydophosphamide-Induced Abnormalities in the Incisors of the Rat." Journal of Dental Research 7(56): 809-816. <http://hdl.handle.net/2027.42/67458>

Abstract: A single injection of 75 mg/kg cyclophosphamide caused gross dental abnormalities in rats. Broken, malformed, overgrown, and "extra" incisors developed several weeks after drug treatment. Radioautographic investigations show no unusual features in the morphology or labeling with H3-thymidine in the odontogenic cells. The results suggest that the cytotoxic effect of the drug is a temporary one which induces a residual alteration of tooth growth.

ISSN: 0022-0345

DOIs: 10.1177/00220345770560071601

Handle: http://hdl.handle.net/2027.42/67458

Show full item record