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The Role of Spirochetes in Periodontal Disease

dc.contributor.authorLoesche, Walter J.en_US
dc.date.accessioned2010-04-13T20:06:27Z
dc.date.available2010-04-13T20:06:27Z
dc.date.issued1988en_US
dc.identifier.citationLoesche, W.J. (1988). "The Role of Spirochetes in Periodontal Disease." Advances in Dental Research 2(2): 275-283. <http://hdl.handle.net/2027.42/68092>en_US
dc.identifier.issn0895-9374en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/68092
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3271022&dopt=citationen_US
dc.description.abstractThe spirochetal accumulation in subgingival plaque appears to be a function of the clinical severity of periodontal disease. It is not known how many different spirochetal species colonize the plaque, but based upon size alone, there are small, intermediate-sized, and large spirochetes. Four species of small spirochetes are cultivable, and of these, T. denticola has been shown to possess proteolytic and keratinolytic enzymes as well as factors or mechanisms which suppress lymphocyte blastogenesis and inhibit fibroblast and polymorphonuclear leukocyte (PMNL) function. All of these attributes could contribute to periodontal tissue insult. Yet independent of these potential virulence mechanisms, the overgrowth of spirochetes can be clinically useful if simply interpreted as indicating the result of tissue damage. In this case, the spirochetes would be indicators of disease and could be easily monitored by microscopic examination of plaque, or possibly by the measurement of benzoyl-DL-arginine-2-naphthylamide (BANA) hydrolytic activity in the plaque.en_US
dc.format.extent3108 bytes
dc.format.extent2436130 bytes
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dc.publisherSAGE Publicationsen_US
dc.titleThe Role of Spirochetes in Periodontal Diseaseen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelDentistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumThe University of Michigan, School of Dentistry, School of Medicine, Ann Arbor, Michigan 48109-1078en_US
dc.identifier.pmid3271022en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/68092/2/10.1177_08959374880020021201.pdf
dc.identifier.doi10.1177/08959374880020021201en_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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