Longitudinal patterns of antidepressant prescribing in primary care in the UK: comparison with treatment guidelines
dc.contributor.author | Dunn, Rodney L. | en_US |
dc.contributor.author | Donoghue, John | en_US |
dc.contributor.author | Ozminkowski, Ronald J. | en_US |
dc.contributor.author | Stephenson, Deborah | en_US |
dc.contributor.author | Hylan, Timothy R. | en_US |
dc.date.accessioned | 2010-04-14T13:56:28Z | |
dc.date.available | 2010-04-14T13:56:28Z | |
dc.date.issued | 1999 | en_US |
dc.identifier.citation | Dunn, Rodney; Donoghue, John; Ozminkowski, Ronald; Stephenson, Deborah; Hylan, Timothy (1999). "Longitudinal patterns of antidepressant prescribing in primary care in the UK: comparison with treatment guidelines." Journal of Psychopharmacology 2(13): 136-143. <http://hdl.handle.net/2027.42/68732> | en_US |
dc.identifier.issn | 0269-8811 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/68732 | |
dc.description.abstract | The objective of this study was to determine whether patients beginning therapy on the most common tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) differed in their likelihood of having antidepressant treatment that was consistent with recommended treatment guidelines in the UK. An analytical file constructed from a large general practitioner medical records database (DIN-LINK) from the UK for the years 1992-97 was constructed. A total of 16 204 patients with a new episode of antidepressant therapy who initiated therapy on one of the most often prescribed TCAs (amitriptyline, dothiepin, imipramine and lofepramine) or SSRIs (fluoxetine, paroxetine and sertraline) were analysed. A dichotomous measure was defined to indicate whether subjects were prescribed at least 120 days of antidepressant therapy at an adequate average daily dose within the first 6 months after initiation of therapy. Only 6.0% of patients initiating therapy on aTCA and 32.9% of patients initiating therapy on a SSRI were prescribed antidepressant treatment that was consistent with treatment guidelines. After controlling for observable characteristics, patients who initiated therapy on a SSRI were much more likely (odds ratio=7.473, p<0.001) to have a prescribed average daily dose and duration consistent with recommended treatment guidelines within the first 6 months of initiating therapy than were patients who initiated therapy on a TCA. These findings suggest that initial antidepressant selection is an important determinant of whether the subsequent course of treatment is consistent with current national guidelines for the treatment of depression in the UK. | en_US |
dc.format.extent | 3108 bytes | |
dc.format.extent | 1325974 bytes | |
dc.format.mimetype | text/plain | |
dc.format.mimetype | application/pdf | |
dc.publisher | SAGE Publication | en_US |
dc.subject.other | Antidepressants | en_US |
dc.subject.other | Depression | en_US |
dc.subject.other | Drug Prescribing Patterns | en_US |
dc.subject.other | Selective Serotonin Reuptake Inhibitors | en_US |
dc.subject.other | Tricyclic Antidepressants | en_US |
dc.title | Longitudinal patterns of antidepressant prescribing in primary care in the UK: comparison with treatment guidelines | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | PCS Health, Liverpool, UK | en_US |
dc.contributor.affiliationother | The MEDSTAT Group, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Lilly Industries, Basingstoke, UK | en_US |
dc.contributor.affiliationother | Eli Lilly and Company, Indianapolis, IN, USA | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/68732/2/10.1177_026988119901300204.pdf | |
dc.identifier.doi | 10.1177/026988119901300204 | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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