Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for prostate cancer Genetics using novel sumLINK and sumLOD analyses
dc.contributor.author | Christensen, G. Bryce | en_US |
dc.contributor.author | Baffoe-Bonnie, Agnes B. | en_US |
dc.contributor.author | George, Asha | en_US |
dc.contributor.author | Powell, Isaac | en_US |
dc.contributor.author | Bailey-Wilson, Joan E. | en_US |
dc.contributor.author | Carpten, John D. | en_US |
dc.contributor.author | Giles, Graham G. | en_US |
dc.contributor.author | Hopper, John L. | en_US |
dc.contributor.author | Severi, Gianluca | en_US |
dc.contributor.author | English, Dallas R. | en_US |
dc.contributor.author | Foulkes, William D. | en_US |
dc.contributor.author | Maehle, Lovise | en_US |
dc.contributor.author | Moller, Pal | en_US |
dc.contributor.author | Eeles, Ros | en_US |
dc.contributor.author | Easton, Douglas | en_US |
dc.contributor.author | Badzioch, Michael D. | en_US |
dc.contributor.author | Whittemore, Alice S. | en_US |
dc.contributor.author | Oakley-Girvan, Ingrid | en_US |
dc.contributor.author | Hsieh, Chih-Lin | en_US |
dc.contributor.author | Dimitrov, Latchezar | en_US |
dc.contributor.author | Xu, Jianfeng | en_US |
dc.contributor.author | Stanford, Janet L. | en_US |
dc.contributor.author | Johanneson, Bo | en_US |
dc.contributor.author | Deutsch, Kerry | en_US |
dc.contributor.author | McIntosh, Laura | en_US |
dc.contributor.author | Ostrander, Elaine A. | en_US |
dc.contributor.author | Wiley, Kathleen E. | en_US |
dc.contributor.author | Isaacs, Sarah D. | en_US |
dc.contributor.author | Walsh, Patrick C. | en_US |
dc.contributor.author | Isaacs, William B. | en_US |
dc.contributor.author | Thibodeau, Stephen N. | en_US |
dc.contributor.author | McDonnell, Shannon K. | en_US |
dc.contributor.author | Hebbring, Scott | en_US |
dc.contributor.author | Schaid, Daniel J. | en_US |
dc.contributor.author | Lange, Ethan M. | en_US |
dc.contributor.author | Cooney, Kathleen A. | en_US |
dc.contributor.author | Tammela, Teuvo L. J. | en_US |
dc.contributor.author | Schleutker, Johanna | en_US |
dc.contributor.author | Paiss, Thomas | en_US |
dc.contributor.author | Maier, Christiane | en_US |
dc.contributor.author | Grönberg, Henrik | en_US |
dc.contributor.author | Wiklund, Fredrik | en_US |
dc.contributor.author | Emanuelsson, Monica | en_US |
dc.contributor.author | Farnham, James M. | en_US |
dc.contributor.author | Cannon-Albright, Lisa A. | en_US |
dc.contributor.author | Camp, Nicola J. | en_US |
dc.date.accessioned | 2010-05-07T18:07:34Z | |
dc.date.available | 2011-03-01T16:26:45Z | en_US |
dc.date.issued | 2010-05-15 | en_US |
dc.identifier.citation | Christensen, G. Bryce; Baffoe-Bonnie, Agnes B.; George, Asha; Powell, Isaac; Bailey-Wilson, Joan E.; Carpten, John D.; Giles, Graham G.; Hopper, John L.; Severi, Gianluca; English, Dallas R.; Foulkes, William D.; Maehle, Lovise; Moller, Pal; Eeles, Ros; Easton, Douglas; Badzioch, Michael D.; Whittemore, Alice S.; Oakley-Girvan, Ingrid; Hsieh, Chih-Lin; Dimitrov, Latchezar; Xu, Jianfeng; Stanford, Janet L.; Johanneson, Bo; Deutsch, Kerry; McIntosh, Laura; Ostrander, Elaine A.; Wiley, Kathleen E.; Isaacs, Sarah D.; Walsh, Patrick C.; Isaacs, William B.; Thibodeau, Stephen N.; McDonnell, Shannon K.; Hebbring, Scott; Schaid, Daniel J.; Lange, Ethan M.; Cooney, Kathleen A.; Tammela, Teuvo L.J.; Schleutker, Johanna; Paiss, Thomas; Maier, Christiane; GrÖnberg, Henrik; Wiklund, Fredrik; Emanuelsson, Monica; Farnham, James M.; Cannon-Albright, Lisa A.; Camp, Nicola J. (2010). "Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for prostate cancer Genetics using novel sumLINK and sumLOD analyses." The Prostate 70(7): 735-744. <http://hdl.handle.net/2027.42/71371> | en_US |
dc.identifier.issn | 0270-4137 | en_US |
dc.identifier.issn | 1097-0045 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/71371 | |
dc.description.abstract | BACKGROUND Prostate cancer (PC) is generally believed to have a strong inherited component, but the search for susceptibility genes has been hindered by the effects of genetic heterogeneity. The recently developed sumLINK and sumLOD statistics are powerful tools for linkage analysis in the presence of heterogeneity. METHODS We performed a secondary analysis of 1,233 PC pedigrees from the International Consortium for Prostate Cancer Genetics (ICPCG) using two novel statistics, the sumLINK and sumLOD. For both statistics, dominant and recessive genetic models were considered. False discovery rate (FDR) analysis was conducted to assess the effects of multiple testing. RESULTS Our analysis identified significant linkage evidence at chromosome 22q12, confirming previous findings by the initial conventional analyses of the same ICPCG data. Twelve other regions were identified with genome-wide suggestive evidence for linkage. Seven regions (1q23, 5q11, 5q35, 6p21, 8q12, 11q13, 20p11–q11) are near loci previously identified in the initial ICPCG pooled data analysis or the subset of aggressive PC pedigrees. Three other regions (1p12, 8p23, 19q13) confirm loci reported by others, and two (2p24, 6q27) are novel susceptibility loci. FDR testing indicates that over 70% of these results are likely true positive findings. Statistical recombinant mapping narrowed regions to an average of 9 cM. CONCLUSIONS Our results represent genomic regions with the greatest consistency of positive linkage evidence across a very large collection of high-risk PC pedigrees using new statistical tests that deal powerfully with heterogeneity. These regions are excellent candidates for further study to identify PC predisposition genes. Prostate 70: 735–744, 2010. © 2010 Wiley-Liss, Inc. | en_US |
dc.format.extent | 219326 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for prostate cancer Genetics using novel sumLINK and sumLOD analyses | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan ICPCG Group ; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina | en_US |
dc.contributor.affiliationum | University of Michigan ICPCG Group ; University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | University of Utah ICPCG Group and Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah ; Division of Genetic Epidemiology, University of Utah School of Medicine, 391, Chipeta Way, Suite D, Salt Lake City, UT 84108. | en_US |
dc.contributor.affiliationother | African American Hereditary Prostate Cancer ICPCG Group ; Fox Chase Cancer Center, Philadelphia, Pennsylvania ; National Human Genome Research Institute, NIH, Bethesda, Maryland | en_US |
dc.contributor.affiliationother | African American Hereditary Prostate Cancer ICPCG Group ; Fox Chase Cancer Center, Philadelphia, Pennsylvania | en_US |
dc.contributor.affiliationother | African American Hereditary Prostate Cancer ICPCG Group ; Karmanos Cancer Institute, Wayne State University, Detroit, Michigan | en_US |
dc.contributor.affiliationother | African American Hereditary Prostate Cancer ICPCG Group ; National Human Genome Research Institute, NIH, Bethesda, Maryland | en_US |
dc.contributor.affiliationother | African American Hereditary Prostate Cancer ICPCG Group ; Translational Genomics Research Institute, Genetic Basis of Human Disease Research Division, Phoenix, Arizona | en_US |
dc.contributor.affiliationother | ACTANE Consortium ICPCG Group ; Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia | en_US |
dc.contributor.affiliationother | ACTANE Consortium ICPCG Group ; Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia | en_US |
dc.contributor.affiliationother | ACTANE Consortium ICPCG Group ; Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia | en_US |
dc.contributor.affiliationother | ACTANE Consortium ICPCG Group ; Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia | en_US |
dc.contributor.affiliationother | ACTANE Consortium ICPCG Group ; Department of Oncology, McGill University, Montreal, Quebec, Canada | en_US |
dc.contributor.affiliationother | ACTANE Consortium ICPCG Group ; The Norwegian Radium Hospital, Oslo, Norway | en_US |
dc.contributor.affiliationother | ACTANE Consortium ICPCG Group ; The Norwegian Radium Hospital, Oslo, Norway | en_US |
dc.contributor.affiliationother | ACTANE Consortium ICPCG Group ; Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Surrey, UK | en_US |
dc.contributor.affiliationother | ACTANE Consortium ICPCG Group ; Cancer Research UK Genetic Epidemiology Unit, Cambridge, UK | en_US |
dc.contributor.affiliationother | ACTANE Consortium ICPCG Group ; Division of Medical Genetics, University of Washington Medical Center, Seattle, Washington | en_US |
dc.contributor.affiliationother | BC/CA/HI ICPCG Group ; Department of Health Research and Policy, Stanford School of Medicine, Stanford, California ; Stanford Comprehensive Cancer Center, Stanford School of Medicine, Stanford, California | en_US |
dc.contributor.affiliationother | BC/CA/HI ICPCG Group ; Stanford Comprehensive Cancer Center, Stanford School of Medicine, Stanford, California | en_US |
dc.contributor.affiliationother | BC/CA/HI ICPCG Group ; Department of Urology and Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California | en_US |
dc.contributor.affiliationother | Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina | en_US |
dc.contributor.affiliationother | Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina | en_US |
dc.contributor.affiliationother | FHCRC ICPCG Group ; Fred Hutchinson Cancer Research Center, Divisions of Public Health Sciences, Seattle, Washington | en_US |
dc.contributor.affiliationother | FHCRC ICPCG Group ; Cancer Genetics Branch, National Institutes of Health, Bethesda, Maryland | en_US |
dc.contributor.affiliationother | FHCRC ICPCG Group ; Institute for Systems Biology, Seattle, Washington | en_US |
dc.contributor.affiliationother | FHCRC ICPCG Group ; Fred Hutchinson Cancer Research Center, Divisions of Public Health Sciences, Seattle, Washington | en_US |
dc.contributor.affiliationother | FHCRC ICPCG Group ; Cancer Genetics Branch, National Institutes of Health, Bethesda, Maryland | en_US |
dc.contributor.affiliationother | Johns Hopkins University ICPCG Group and Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | Johns Hopkins University ICPCG Group and Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | Johns Hopkins University ICPCG Group and Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | Johns Hopkins University ICPCG Group and Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | Mayo Clinic ICPCG Group and Mayo Clinic, Rochester, Minnesota | en_US |
dc.contributor.affiliationother | Mayo Clinic ICPCG Group and Mayo Clinic, Rochester, Minnesota | en_US |
dc.contributor.affiliationother | Mayo Clinic ICPCG Group and Mayo Clinic, Rochester, Minnesota | en_US |
dc.contributor.affiliationother | Mayo Clinic ICPCG Group and Mayo Clinic, Rochester, Minnesota | en_US |
dc.contributor.affiliationother | University of Tampere ICPCG Group, University of Tampere and Tampere University Hospital, Tampere, Finland | en_US |
dc.contributor.affiliationother | University of Tampere ICPCG Group, University of Tampere and Tampere University Hospital, Tampere, Finland | en_US |
dc.contributor.affiliationother | University of Ulm ICPCG Group ; Department of Urology, University of Ulm, Ulm, Germany | en_US |
dc.contributor.affiliationother | University of Ulm ICPCG Group ; Institute of Human Genetics, University of Ulm, Ulm, Germany | en_US |
dc.contributor.affiliationother | University of UmeÅ ICPCG Group ; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden | en_US |
dc.contributor.affiliationother | University of UmeÅ ICPCG Group ; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden | en_US |
dc.contributor.affiliationother | University of UmeÅ ICPCG Group ; Oncologic Centre, UmeÅ University, UmeÅ, Sweden | en_US |
dc.contributor.affiliationother | University of Utah ICPCG Group and Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah | en_US |
dc.contributor.affiliationother | University of Utah ICPCG Group and Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah | en_US |
dc.contributor.affiliationother | University of Utah ICPCG Group and Division of Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah | en_US |
dc.identifier.pmid | 20333727 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/71371/1/21106_ftp.pdf | |
dc.identifier.doi | 10.1002/pros.21106 | en_US |
dc.identifier.source | The Prostate | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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