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Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial

dc.contributor.authorEl-Serag, Hashem B.en_US
dc.contributor.authorLee, Pattyen_US
dc.contributor.authorBuchner, Annaen_US
dc.contributor.authorInadomi, John M.en_US
dc.contributor.authorGavin, Michaelen_US
dc.contributor.authorMcCarthy, Denis M.en_US
dc.date.accessioned2010-06-01T18:14:25Z
dc.date.available2010-06-01T18:14:25Z
dc.date.issued2001-04en_US
dc.identifier.citationEl-Serag, Hashem B . ; Lee, Patty; Buchner, Anna; Inadomi, John M . ; Gavin, Michael; McCarthy, Denis M . (2001). "Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial." The American Journal of Gastroenterology 96(4): 979-983. <http://hdl.handle.net/2027.42/71451>en_US
dc.identifier.issn0002-9270en_US
dc.identifier.issn1572-0241en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/71451
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11316215&dopt=citationen_US
dc.description.abstractPrevious uncontrolled studies suggested a therapeutic benefit for treating gastroesophageal reflux disease (GERD) among patients with laryngitis. The present study is the first randomized, placebo-controlled, double-blind study of gastric acid suppression among patients with laryngitis in the United States. Methods : Patients diagnosed with idiopathic chronic laryngitis were randomized to receive either lansoprazole 30 mg p.o. b.i.d. or a matching placebo for 3 months. Before randomization, all patients underwent upper endoscopy, dual probe ambulatory 24-h esophageal pH-metry, and laryngoscopy, as well as completing a symptom questionnaire for GERD and laryngitis. The primary outcome of treatment was the complete resolution of laryngeal symptoms. Results : A total of 22 patients with symptoms and signs of chronic laryngitis were enrolled, 20 of whom completed the study. At baseline, there were no significant differences between the two groups with regards to GERD symptoms, erosive esophagitis, proximal and distal esophageal pH-metry, or laryngeal signs and symptoms. In an intention-to-treat analysis, six patients in the lansoprazole group (50%) and only one patient (10%) in the placebo group achieved a complete symptomatic response, p =; 0.04. Apart from receiving lansoprazole, there were no significant differences between responders and nonresponders in any of baseline esophageal or laryngeal signs and symptoms. Conclusions : Empirical treatment with lansoprazole is efficacious in relieving symptoms of laryngitis compared to placebo. Such treatment can be considered as a first-line option in managing patients with idiopathic chronic laryngitis.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights2001 by Am. Coll. of Gastroenterologyen_US
dc.titleLansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trialen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivisions of Gastroenterology and Health Services Research, Ann Arbor VA Medical Center and University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationotherDivisions of Gastroenterology and Health Services Research, Houston VA Medical Center and Baylor College of Medicine, Houston, Texasen_US
dc.contributor.affiliationotherOtolaryngology Department and Division of Gastroenterology, Albuquerque VA Medical Center and University of New Mexico, Albuquerque, New Mexicoen_US
dc.identifier.pmid11316215en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/71451/1/j.1572-0241.2001.03681.x.pdf
dc.identifier.doi10.1111/j.1572-0241.2001.03681.xen_US
dc.identifier.sourceThe American Journal of Gastroenterologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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