Dopaminergic regulation of orexin neurons
dc.contributor.author | Bubser, Michael | en_US |
dc.contributor.author | Fadel, Jim R. | en_US |
dc.contributor.author | Jackson, Lela L. | en_US |
dc.contributor.author | Meador-Woodruff, James H. | en_US |
dc.contributor.author | Jing, Deqiang | en_US |
dc.contributor.author | Deutch, Ariel Y. | en_US |
dc.date.accessioned | 2010-06-01T18:18:11Z | |
dc.date.available | 2010-06-01T18:18:11Z | |
dc.date.issued | 2005-06 | en_US |
dc.identifier.citation | Bubser, Michael; Fadel, Jim R.; Jackson, Lela L.; Meador-Woodruff, James H.; Jing, Deqiang; Deutch, Ariel Y. (2005). "Dopaminergic regulation of orexin neurons." European Journal of Neuroscience 21(11): 2993-3001. <http://hdl.handle.net/2027.42/71513> | en_US |
dc.identifier.issn | 0953-816X | en_US |
dc.identifier.issn | 1460-9568 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/71513 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15978010&dopt=citation | en_US |
dc.description.abstract | Orexin/hypocretin neurons in the lateral hypothalamus and adjacent perifornical area (LH/PFA) innervate midbrain dopamine (DA) neurons that project to corticolimbic sites and subserve psychostimulant-induced locomotor activity. However, it is not known whether dopamine neurons in turn regulate the activity of orexin cells. We examined the ability of dopamine agonists to activate orexin neurons in the rat, as reflected by induction of Fos. The mixed dopamine agonist apomorphine increased Fos expression in orexin cells, with a greater effect on orexin neurons located medial to the fornix. Both the selective D1-like agonist, A-77636, and the D2-like agonist, quinpirole, also induced Fos in orexin cells, suggesting that stimulation of either receptor subtype is sufficient to activate orexin neurons. Consistent with this finding, combined SCH 23390 (D1 antagonist)–haloperidol (D2 antagonist) pretreatment blocked apomorphine-induced activation of medial as well as lateral orexin neurons; in contrast, pretreatment with either the D1-like or D2-like antagonists alone did not attenuate apomorphine-induced activation of medial orexin cells. In situ hybridization histochemistry revealed that LH/PFA cells rarely express mRNAs encoding dopamine receptors, suggesting that orexin cells are transsynaptically activated by apomorphine. We therefore lesioned the nucleus accumbens, a site known to regulate orexin cells, but this treatment did not alter apomorphine-elicited activation of medial or lateral orexin neurons. Interestingly, apomorphine failed to activate orexin cells in isoflurane-anaesthetized animals. These data suggest that apomorphine-induced arousal but not accumbens-mediated hyperactivity is required for dopamine to transsynaptically activate orexin neurons. | en_US |
dc.format.extent | 387398 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Science Ltd | en_US |
dc.rights | 2005 Federation of European Neuroscience Societies | en_US |
dc.subject.other | Apomorphine | en_US |
dc.subject.other | Fos | en_US |
dc.subject.other | Lateral Hypothalamus | en_US |
dc.subject.other | Nucleus Accumbens | en_US |
dc.subject.other | Rat | en_US |
dc.title | Dopaminergic regulation of orexin neurons | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA | en_US |
dc.contributor.affiliationother | Department of Pharmacology, Vanderbilt University Medical Center, Nashville, USA | en_US |
dc.contributor.affiliationother | Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC | en_US |
dc.identifier.pmid | 15978010 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/71513/1/j.1460-9568.2005.04121.x.pdf | |
dc.identifier.doi | 10.1111/j.1460-9568.2005.04121.x | en_US |
dc.identifier.source | European Journal of Neuroscience | en_US |
dc.identifier.citedreference | Akiyama, M., Yuasa, T., Hayasaka, N., Horikawa, K., Sakurai, T. & Shibata, S. ( 2004 ) Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice. Eur. J. Neurosci., 20, 3054 – 3062. | en_US |
dc.identifier.citedreference | Asper, H., Baggioline, M., BÜrki, H. R., Lauener, H., Ruch, W. & Stille, G. ( 1973 ) Tolerance phenomena with neuroleptics catalepsy, apomorphine stereotypies and striatal dopamine metabolism in the rat after single and repeated administration of loxapine and haloperidol. Eur. J. Pharmacol., 22, 287 – 294. | en_US |
dc.identifier.citedreference | Baldo, B. A., Daniel, R. A., Berridge, C. W. & Kelley, A. E. ( 2003 ) Overlapping distributions of orexin/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress. J. Comp. Neurol., 464, 220 – 237. | en_US |
dc.identifier.citedreference | Baldo, B. A., Gual-Bonilla, L., Sijapati, K., Danie1, R. A., Landry, C. F. & Kelley, A. E. ( 2004 ) Activation of a subpopulation of orexin/hypocretin-containing hypothalamic neurons by GABA A receptor-mediated inhibition of the nucleus accumbens shell, but not by exposure to a novel environment. Eur. J. Neurosci., 19, 376 – 386. | en_US |
dc.identifier.citedreference | Bouret, S. G., Draper, S. J. & Simerly, R. B. ( 2004 ) Formation of projection pathways from the arcuate nucleusof the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice. J. Neurosci., 24, 2797 – 2805. | en_US |
dc.identifier.citedreference | Broberger, C., De Lecea, L., Sutcliffe, J. G. & Hokfelt, T. ( 1998 ) Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J. Comp. Neurol., 402, 460 – 474. | en_US |
dc.identifier.citedreference | Brunetti, L., Orlando, G., Recinella, L., Michelotto, B., Ferrante, C. & Vacca, M. ( 2004 ) Resistin, but not adiponectin, inhibits dopamine and norepinephrine release in the hypothalamus. Eur. J. Pharmacol., 493, 41 – 44. | en_US |
dc.identifier.citedreference | Bubser, M. & Deutch, A. Y. ( 1998 ) Thalamic paraventricular nucleus neurons collateralize to innervate the prefrontal cortex and nucleus accumbens. Brain Res., 787, 304 – 310. | en_US |
dc.identifier.citedreference | Carr, K. D., Kim, G. Y. & Cabeza de Vaca, S. ( 2001 ) Rewarding and locomotor-activating effects of direct dopamine receptor agonists are augmented by chronic food restriction in rats. Psychopharmacology, 154, 420 – 428. | en_US |
dc.identifier.citedreference | Damask, S. P., Bovenkerk, K. A., De la Pena, G., Hoversten, K. M., Peters, D. B., Valentine, A. M. & Meador-Woodruff, J. H. ( 1996 ) Differential effects of clozapine and haloperidol on dopamine receptor mRNA expression in rat striatum and cortex. Mol. Brain Res., 41, 241 – 249. | en_US |
dc.identifier.citedreference | Espana, R. A., Baldo, B. A., Kelley, A. E. & Berridge, C. W. ( 2001 ) Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action. Neuroscience, 106, 699 – 715. | en_US |
dc.identifier.citedreference | Espana, R. A., Valentino, R. J. & Berridge, C. W. ( 2003 ) Fos immunoreactivity in hypocretin-synthesizing and hypocretin-1 receptor-expressing neurons: effects of diurnal and nocturnal spontaneous waking, stress and hypocretin-1 administration. Neuroscience, 121, 201 – 217. | en_US |
dc.identifier.citedreference | Estabrooke, I. V., McCarthy, M. T., Ko, E., Chou. T. C., Chemelli, R. M., Yanagisawa, M., Saper, C. B. & Scammell, T. E. ( 2001 ) Fos expression in orexin neurons varies with behavioral state. J. Neurosci., 21, 1656 – 1662. | en_US |
dc.identifier.citedreference | Fadel, J., Bubser, M. & Deutch, A. Y. ( 2002 ) Differential activation of orexin neurons by antipsychotic drugs associated with weight gain. J. Neurosci., 22, 6742 – 6746. | en_US |
dc.identifier.citedreference | Fadel, J. & Deutch, A. Y. ( 2002 ) Anatomical substrates of orexin–dopamine interactions: lateral hypothalamic projections to the ventral tegmental area. Neuroscience, 111, 379 – 387. | en_US |
dc.identifier.citedreference | Fetissov, S. O., Meguid, M. M., Sato, T. & Zhang, L. H. ( 2002 ) Expression of dopaminergic receptors in the hypothalamus of lean and obese Zucker rats and food intake. Am. J. Physiol. Regul. Integr. Comp. Physiol., 283, R905 – R910. | en_US |
dc.identifier.citedreference | Fujiki, N., Yoshida, Y., Ripley, B., Honda, K., Mignot, E. & Nishino, S. ( 2001 ) Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation. Neuroreport, 12, 993 – 997. | en_US |
dc.identifier.citedreference | Hagan, J. J., Leslie, R. A., Patel, S., Evans, M. L., Wattam, T. A., Holmes, S., Benham, C. D., Taylor, S. G., Routledge, C., Hemmati, P., Munton, R. P., Ashmeade, T. E., Shah, A. S., Hatcher, J. P., Hatcher, P. D., Jones, D. N., Smith, M. I., Piper, D. C., Hunter, A. J., Porter, R. A. & Upton, N. ( 1999 ) Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc. Natl Acad. Sci. USA, 96, 10911 – 10916. | en_US |
dc.identifier.citedreference | Horvath, T. L., Peyron, C., Diano, S., Ivanov, A., Aston-Jones, G., Kilduff, T. S. & van Den Pol, A. N. ( 1999 ) Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. J. Comp. Neurol., 415, 145 – 159. | en_US |
dc.identifier.citedreference | Isaac, S. O. & Berridge, C. W. ( 2003 ) Wake-promoting actions of dopamine D1 and D2 receptor stimulation. J. Pharmacol. Exp. Ther., 307, 386 – 394. | en_US |
dc.identifier.citedreference | Kafetzopoulos, E. ( 1986 ) Effects of amphetamine and apomorphine on locomotor activity after kainic acid lesion of the nucleus accumbens septi in the rat. Psychopharmacology, 88, 271 – 274. | en_US |
dc.identifier.citedreference | Klemm, N., Murrin, L. C. & Kuhar, M. J. ( 1979 ) Neuroleptic and dopamine receptors: autoradiographic localization of [3H]spiperone in rat brain. Brain Res., 169, 1 – 9. | en_US |
dc.identifier.citedreference | KÖhler, C., Haglund, L., Ögren, S. -O. & Ängeby, T. ( 1981 ) Regional blockade by neuroleptic drugs of in vivo 3H-spiperone binding in the rat brain. Relation to blockade of apomorphine induced hyperactivity and stereotypies. J. Neural Transm., 52, 163 – 173. | en_US |
dc.identifier.citedreference | Korotkova, T. M., Sergeeva, O. A., Eriksson, K. S., Haas, H. L. & Brown, R. E. ( 2003 ) Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins. J. Neurosci., 23, 7 – 11. | en_US |
dc.identifier.citedreference | Kropf, W., Kuschinsky, K. & Krieglstein, J. ( 1989 ) Apomorphine-induced alterations in cortical EEG activity of rats. Involvement of D-1 and D-2 dopamine receptors. Naunyn-Schmiedeberg's Arch. Pharmacol., 340, 718 – 725. | en_US |
dc.identifier.citedreference | de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L., Gautvik, V. T., Bartlett, F. S., Frankel, W. N., van den Pol, A. N., Bloom, F. E., Gautvik, K. M. & Sutcliffe, J. G. ( 1998 ) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl Acad. Sci. USA, 95, 322 – 327. | en_US |
dc.identifier.citedreference | Lee, S. K. & Hollenbeck, P. J. ( 2003 ) Organization and translation of mRNA in sympathetic axons. J. Cell Sci., 116, 4467 – 4478. | en_US |
dc.identifier.citedreference | Lee, T. L., Hsu, C. T., Yen, S. T., Lai, C. W. & Cheng, J. T. ( 1998 ) Activation of beta3-adrenoceptors by exogenous dopamine to lower glucose uptake into rat adipocytes. J. Auton. Nerv. Syst., 74, 86 – 90. | en_US |
dc.identifier.citedreference | Leibowitz, S. F., Jhanwar-Uniyal, M., Dvorkin, B. & Makman, M. H. ( 1982 ) Distribution of alpha-adrenergic, beta-adrenergic and dopaminergic receptors in discrete hypothalamic areas of rat. Brain Res., 233, 97 – 114. | en_US |
dc.identifier.citedreference | Li, Y. & van den Pol, A. N. ( 2005 ) Direct and indirect inhibition by catecholamines of hypocretin/orexin neurons. J. Neurosci., 25, 173 – 183. | en_US |
dc.identifier.citedreference | Lu, X. Y., Bagnol, D., Burke, S., Akil, H. & Watson, S. J. ( 2000 ) Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting. Horm. Behav., 37, 335 – 344. | en_US |
dc.identifier.citedreference | Mansour, A., Meador-Woodruff, J. H., Bunzow, J. R., Civelli, O., Akil, H. & Watson, S. J. ( 1990 ) Localization of dopamine D2 receptor mRNA and D1 and D2 receptor binding in the rat brain and pituitary: an in situ hybridization-receptor autoradiographic analysis. J. Neurosci., 10, 2587 – 2600. | en_US |
dc.identifier.citedreference | Mansour, A., Meador-Woodruff, J. H., Zhou, Q. Y., Civelli, O., Akil, H. & Watson, S. J. ( 1991 ) A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques. Neuroscience, 45, 359 – 371. | en_US |
dc.identifier.citedreference | Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M. & Elmquist, J. K. ( 2001 ) Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol., 435, 6 – 25. | en_US |
dc.identifier.citedreference | Meister, B. ( 2000 ) Control of food intake via leptin receptors in the hypothalamus. Vitam. Horm., 59, 265 – 304. | en_US |
dc.identifier.citedreference | Meller, E., Bohmaker, K., Goldstein, M. & Friedhoff, A. J. ( 1985 ) Inactivation of D1 and D2 dopamine receptors by N -ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vivo: selective protection by neuroleptics. J. Pharmacol. Exp. Ther., 233, 656 – 662. | en_US |
dc.identifier.citedreference | Millan, M. J., Maiofiss, L., Cussac, D., Audinot, V., Boutin, J. A. & Newman-Tancredi, A. ( 2002 ) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J. Pharmacol. Exp. Ther., 303, 791 – 804. | en_US |
dc.identifier.citedreference | Murphy, J. A., Deurveilher, S. & Semba, K. ( 2003 ) Stimulant doses of caffeine induce c-FOS activation in orexin/hypocretin-containing neurons in rat. Neuroscience, 121, 269 – 275. | en_US |
dc.identifier.citedreference | Nakamura, T., Uramura, K., Nambu, T., Yada, T., Goto, K., Yanagisawa, M. & Sakurai, T. ( 2000 ) Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system. Brain Res., 873, 181 – 187. | en_US |
dc.identifier.citedreference | Nakano, S., Hara, C. & Ogawa, N. ( 1980 ) Circadian rhythm of apomorphine-induced stereotypy in rats. Pharmacol. Biochem. Behav., 12, 459 – 461. | en_US |
dc.identifier.citedreference | Nasello, A. G., Tieppo, C. A. & Felicio, L. F. ( 1995 ) Apomorphine-induced yawning in the rat: influence of fasting and time of day. Physiol. Behav., 57, 967 – 971. | en_US |
dc.identifier.citedreference | Nisoli, E., Tonello, C., Memorandum, M. & Carruba, M. O. ( 1992 ) Biochemical and functional identification of a novel dopamine receptor subtype in rat brown adipose tissue. Its role in modulating sympathetic stimulation-induced thermogenesis. J. Pharmacol. Exp. Ther., 263, 823 – 829. | en_US |
dc.identifier.citedreference | Olszewski, P. K., Li, D., Grace, M. K., Billington, C. J., Kotz, C. M. & Levine, A. S. ( 2003 ) Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus. Peptides, 24, 597 – 602. | en_US |
dc.identifier.citedreference | Paxinos, G. & Watson, C. ( 1986 ) The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego, CA. | en_US |
dc.identifier.citedreference | Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G. & Kilduff, T. S. ( 1998 ) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci., 18, 9996 – 10015. | en_US |
dc.identifier.citedreference | Ritter, L. M. & Meador-Woodruff, J. H. ( 1997 ) Antipsychotic regulation of hippocampal dopamine receptor messenger RNA expression. Biol. Psychiatry, 42, 155 – 164. | en_US |
dc.identifier.citedreference | Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., Arch., J. R., Buckingham, R. E., Haynes, A. C., Carr, S. A., Annan, R. S., McNulty, D. E., Liu, W. S., Terrett, J. A., Elshourbagy, N. A., Bergsma, D. J. & Yanagisawa, M. ( 1998 ) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell, 92, 573 – 585. | en_US |
dc.identifier.citedreference | Saller, C. F., Kreamer, L. D., Adamovage, L. A. & Salama, A. I. ( 1989 ) Dopamine receptor occupancy in vivo: measurement using N -ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). Life Sci., 45, 917 – 929. | en_US |
dc.identifier.citedreference | Satoh, S., Matsumura, H., Nakajima, T., Nakahama, K., Kanbayashi, T., Nishino, S., Yoneda, H. & Shigeyoshi, Y. ( 2003 ) Inhibition of rostral basal forebrain neurons promotes wakefulness and induces FOS in orexin neurons. Eur. J. Neurosci., 17, 1635 – 1645. | en_US |
dc.identifier.citedreference | Savasta, M., Dubois, A. & Scatton, B. ( 1986 ) Autoradiographic localization of D1 dopamine receptors in the rat brain with [3H]SCH 23390. Brain Res., 375, 291 – 301. | en_US |
dc.identifier.citedreference | Scammell, T. E., Estabrooke, I. V., McCarthy, M. T., Chemelli, R. M., Yanagisawa, M., Miller, M. S. & Saper, C. B. ( 2000 ) Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J. Neurosci., 20, 8620 – 8628. | en_US |
dc.identifier.citedreference | Steward, O. & Schuman. E. M. ( 2001 ) Protein synthesis at synaptic sites on dendrites. Annu. Rev. Neurosci., 24, 299 – 325. | en_US |
dc.identifier.citedreference | Stratford, T. R. & Kelley, A. E. ( 1999 ) Evidence of a functional relationship between the nucleus accumbens shell and lateral hypothalamus subserving the control of feeding behavior. J. Neurosci., 19, 11040 – 11048. | en_US |
dc.identifier.citedreference | Uramura, K., Funahashi, H., Muroya, S., Shioda, S., Takigawa, M. & Yada, T. ( 2001 ) Orexin-a activates phospholipase C- and protein kinase C-mediated Ca 2+ signaling in dopamine neurons of the ventral tegmental area. Neuroreport, 12, 1885 – 1889. | en_US |
dc.identifier.citedreference | Usuda, I., Tanaka, K. & Chiba, T. ( 1998 ) Efferent projections of the nucleus accumbens in the rat with special reference to subdivision of the nucleus: biotinylated dextran amine study. Brain Res., 797, 73 – 93. | en_US |
dc.identifier.citedreference | Weissenborn, R. & Winn, P. ( 1992 ) Regulatory behavior, exploration and locomotion following NMDA or 6-OHDA lesions in the rat nucleus accumbens. Behav. Brain Res., 51, 127 – 137. | en_US |
dc.identifier.citedreference | Winsky-Sommerer, R., Boutrel, B. & de Lecea, L. ( 2003 ) The role of the hypocretinergic system in the integration of networks that dictate the states of arousal. Drug News Perspect., 16, 504 – 512. | en_US |
dc.identifier.citedreference | Wisor, J. P., Nishino, S., Sora, I., Uhl, G. H., Mignot, E. & Edgar, D. M. ( 2001 ) Dopaminergic role in stimulant-induced wakefulness. J. Neurosci., 21, 1787 – 1794. | en_US |
dc.identifier.citedreference | Wolf, H. K., Buslei, R., Schmidt-Kastner, R., Schmidt-Kastner, P. K., Pietsch, T., Wiestler, O. D. & Blumcke, I. ( 1996 ) NeuN: a useful neuronal marker for diagnostic histopathology. J. Histochem. Cytochem., 44, 1167 – 1171. | en_US |
dc.identifier.citedreference | Zahm, D. S. & Heimer, L. ( 1993 ) Specificity in the efferent projections of the nucleus accumbens in the rat: comparison of the rostral pole projection patterns with those of the core and shell. J. Comp. Neurol., 327, 220 – 232. | en_US |
dc.identifier.citedreference | Zeitzer, J. M., Buckmaster, C. L., Lyons, D. M. & Mignot, E. ( 2004 ) Locomotor-dependent and -independent components to hypocretin-1 (orexin A) regulation in sleep-wake consolidating monkeys. J. Physiol. (Lond. ), 557, 1045 – 1053. | en_US |
dc.identifier.citedreference | Zhang, W., Klimek, V., Farley, J. T., Zhu, M. Y. & Ordway, G. A. ( 1999 ) Alpha2C adrenoceptors inhibit adenylyl cyclase in mouse striatum: potential activation by dopamine. J. Pharmacol. Exp. Ther., 289, 1286 – 1292. | en_US |
dc.identifier.citedreference | Zheng, H., Corkern, M., Stoyanova, I., Patterson, L. M., Tian, R. & Berthoud, H. R. ( 2003 ) Peptides that regulate food intake: appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons. Am. J. Physiol. Regul. Integr. Comp. Physiol., 284, R1436 – R1444. | en_US |
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