Threshold Distributions of Phenylthiocarbamide (PTC) in the Chinese Population a
dc.contributor.author | Guo, Sun-Wei | en_US |
dc.contributor.author | Shen, Fu-Min | en_US |
dc.contributor.author | Wang, Yuedong | en_US |
dc.contributor.author | Zheng, Chang-Jiang | en_US |
dc.date.accessioned | 2010-06-01T18:20:27Z | |
dc.date.available | 2010-06-01T18:20:27Z | |
dc.date.issued | 1998-11 | en_US |
dc.identifier.citation | GUO, SUN-WEI; SHEN, FU-MIN; WANG, YUE-DONG; ZHENG, CHANG-JIANG (1998). "Threshold Distributions of Phenylthiocarbamide (PTC) in the Chinese Population a ." Annals of the New York Academy of Sciences 855(1 OLFACTION AND TASTE XII: AN INTERNATIONAL SYMPOSIUM ): 810-812. <http://hdl.handle.net/2027.42/71550> | en_US |
dc.identifier.issn | 0077-8923 | en_US |
dc.identifier.issn | 1749-6632 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/71550 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9929690&dopt=citation | en_US |
dc.description.abstract | The ability to taste phenylthiocarbamide (PTC) is a well-documented Mendelian trait. Mapping and cloning the gene(s) responsible for the PTC tasting ability would help to delineate the molecular basis for the variations in PTC tasting ability in humans and to shed new light on taste chemosensory functions. In view of the spectacular successes in genome science, the positional cloning strategy seems to be a feasible approach to the isolation of the gene(s) underlying the PTC tasting ability. As a first step toward mapping the gene(s), we collected PTC taste threshold data on 106 individuals, most of them being university students, in Shanghai, China. Using various parametric and nonparametric statistical methods, we have found that the data set is best described by a bimodal distribution. The frequency of PTC nontasters is estimated to be 10%. This is consistent with the view that the PTC nontasting ability follows a recessive mode of inheritance. Several authors had previously reported PTC data on Chinese living outside China. Our data are, to our knowledge, the first ever collected from the Chinese population within China. | en_US |
dc.format.extent | 204290 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | New York Academy of Sciences 1998 | en_US |
dc.title | Threshold Distributions of Phenylthiocarbamide (PTC) in the Chinese Population a | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Science (General) | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 481092029, USA | en_US |
dc.contributor.affiliationother | Institute of Human Genetics and Division of Epidemiology, University of Minnesota, Minneapolis, Minnesota 55454-1015, USA | en_US |
dc.contributor.affiliationother | Department of Epidemiology, Shanghai Medical University, Shanghai, China | en_US |
dc.contributor.affiliationother | Epidemiology Branch, NIDCD/NIH, Bethesda, Maryland 20892, USA | en_US |
dc.identifier.pmid | 9929690 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/71550/1/j.1749-6632.1998.tb10664.x.pdf | |
dc.identifier.doi | 10.1111/j.1749-6632.1998.tb10664.x | en_US |
dc.identifier.source | Annals of the New York Academy of Sciences | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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