LRb signals act within a distributed network of leptin-responsive neurones to mediate leptin action
dc.contributor.author | Leinninger, Gina M. | en_US |
dc.contributor.author | Myers, M. G. | en_US |
dc.date.accessioned | 2010-06-01T18:22:28Z | |
dc.date.available | 2010-06-01T18:22:28Z | |
dc.date.issued | 2008-01 | en_US |
dc.identifier.citation | Leinninger, G. M.; Myers, M. G. (2008). "LRb signals act within a distributed network of leptin-responsive neurones to mediate leptin action." Acta Physiologica 192(1): 49-59. <http://hdl.handle.net/2027.42/71583> | en_US |
dc.identifier.issn | 1748-1708 | en_US |
dc.identifier.issn | 1748-1716 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/71583 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18171429&dopt=citation | en_US |
dc.format.extent | 598560 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 2008 The Authors Journal compilation 2008 Scandinavian Physiological Society | en_US |
dc.subject.other | Dopamine | en_US |
dc.subject.other | Energy Balance | en_US |
dc.subject.other | Hypothalamus | en_US |
dc.subject.other | Leptin | en_US |
dc.subject.other | STAT3 | en_US |
dc.title | LRb signals act within a distributed network of leptin-responsive neurones to mediate leptin action | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Physiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 18171429 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/71583/1/j.1748-1716.2007.01784.x.pdf | |
dc.identifier.doi | 10.1111/j.1748-1716.2007.01784.x | en_US |
dc.identifier.source | Acta Physiologica | en_US |
dc.identifier.citedreference | Ahima, R.S., Prabakaran, D., Mantzoros, C.S., Qu, D., Lowell, B.B., Maratos-Flier, E. & Flier, J.S. 1996. Role of leptin in the neuroendocrine response to fasting. Nature 382, 250 – 252. | en_US |
dc.identifier.citedreference | Argetsinger, L.S., Kouadio, J.L., Steen, H., Stensballe, A., Jensen, O.N. & Carter-Su, C. 2004. Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity. Mol Cell Biol 24, 4955 – 4967. | en_US |
dc.identifier.citedreference | Balthasar, N., Coppari, R., McMinn, J., Liu, S.M., Lee, C.E., Tang, V., Kenny, C.D., McGovern, R.A., Chua, S.C. Jr, Elmquist, J.K. & Lowell, B.B. 2004. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42, 983 – 991. | en_US |
dc.identifier.citedreference | Banks, A.S., Davis, S.M., Bates, S.H. & Myers, M.G., Jr. 2000. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 275, 14563 – 14572. | en_US |
dc.identifier.citedreference | Baskin, D.G., Schwartz, M.W., Seeley, R.J., Woods, S.C., Porte, D., Jr, Breininger, J.F., Jonak, Z., Schaefer, J., Krouse, M., Burghardt, C., Campfield, L.A., Burn, P. & Kochan, J.P. 1999. Leptin receptor long-form splice-variant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus. J Histochem Cytochem 47, 353 – 362. | en_US |
dc.identifier.citedreference | Bates, S.H. & Myers, M.G., Jr. 2003. The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol Metab 14, 447 – 452. | en_US |
dc.identifier.citedreference | Bates, S.H., Stearns, W.H., Schubert, M., Tso, A.W.K., Wang, Y., Banks, A.S., Dundon, T.A., Lavery, H.J., Haq, A.K., Maratos-Flier, E., Neel, B.G., Schwartz, M.W. & Myers, M.G., Jr. 2003. STAT3 signaling is required for leptin regulation of energy balance but not reproduction. Nature 421, 856 – 859. | en_US |
dc.identifier.citedreference | Bates, S.H., Dundon, T.A., Seifert, M., Carlson, M., Maratos-Flier, E. & Myers, M.G., Jr. 2004. LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes 53, 3067 – 3073. | en_US |
dc.identifier.citedreference | Bates, S.H., Kulkarni, R.N., Seifert, M. & Myers, M.G., Jr. 2005. Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab 1, 169 – 178. | en_US |
dc.identifier.citedreference | Bergman, R.N. & Ader, M. 2005. Atypical antipsychotics and glucose homeostasis. J Clin Psychiatry 66, 504 – 514. | en_US |
dc.identifier.citedreference | Bjorbaek, C., Elmquist, J.K., Frantz, J.D., Shoelson, S.E. & Flier, J.S. 1998. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1, 619 – 625. | en_US |
dc.identifier.citedreference | Bjorbaek, C., Lavery, H.J., Bates, S.H., Olson, R.K., Davis, S.M., Flier, J.S. & Myers, M.G., Jr. 2000. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J Biol Chem 275, 40649 – 40657. | en_US |
dc.identifier.citedreference | Bjorbaek, C., Buchholz, R.M., Davis, S.M., Bates, S.H., Pierroz, D.D., Gu, H., Neel, B.G., Myers, M.G., Jr & Flier, J.S. 2001. Divergent roles of SHP-2 in ERK activation by leptin receptors. J Biol Chem 276, 4747 – 4755. | en_US |
dc.identifier.citedreference | Bjornholm, M., Munzberg, H., Leshan, R.L., Villanueva, E., Bates, S.H., Louis, G.W., Jones, J.C., Ishida-Takahashi, R., Bjorbaek, C. & Myers, M.G., Jr. 2007. Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest 117, 1354 – 1360. | en_US |
dc.identifier.citedreference | Bodary, P.F., Westrick, R.J., Wickenheiser, K.J., Shen, Y. & Eitzman, D.T. 2002. Effect of leptin on arterial thrombosis following vascular injury in mice. JAMA 287, 1706 – 1709. | en_US |
dc.identifier.citedreference | Bodary, P.F., Shen, Y., Ohman, M., Bahrou, K.L., Vargas, F.B., Cudney, S.S., Wickenheiser, K.J., Myers, M.G., Jr & Eitzman, D.T. 2007. Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance. Arterioscler Thromb Vasc Biol 27, 70 – 76. | en_US |
dc.identifier.citedreference | Boston, B.A., Blaydon, K.M., Varnerin, J. & Cone, R.D. 1997. Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 278, 1641 – 1644. | en_US |
dc.identifier.citedreference | Buettner, C., Pocai, A., Muse, E.D., Etgen, A.M., Myers, M.G., Jr & Rossetti, L. 2006. Critical role of STAT3 in leptin’s metabolic actions. Cell Metab 4, 49 – 60. | en_US |
dc.identifier.citedreference | Butler, A.A. & Cone, R.D. 2002. The melanocortin receptors: lessons from knockout models. Neuropeptides 36, 77 – 84. | en_US |
dc.identifier.citedreference | Butler, A.A., Kesterson, R.A., Khong, K., Cullen, M.J., Pelleymounter, M.A., Dekoning, J., Baetscher, M. & Cone, R.D. 2000. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141, 3518 – 3521. | en_US |
dc.identifier.citedreference | Carpenter, L.R., Farruggella, T.J., Symes, A., Karow, M.L. & Yancopoulos, G. 1998. Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor. Proc Natl Acad Sci USA 95, 6061 – 6066. | en_US |
dc.identifier.citedreference | Carpino, N., Kobayashi, R., Zang, H., Takahashi, Y., Jou, S.T., Feng, J., Nakajima, H. & Ihle, J.N. 2002. Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. Mol Cell Biol 22, 7491 – 7500. | en_US |
dc.identifier.citedreference | Carr, K.D. 2006. Chronic food restriction: enhancing effects on drug reward and striatal cell signaling. Physiol Behav 91, 459 – 472. | en_US |
dc.identifier.citedreference | Chen, A.S., Marsh, D.J., Trumbauer, M.E., Frazier, E.G., Guan, X.M., Yu, H., Rosenblum, C.I., Vongs, A., Feng, Y., Cao, L. et al. 2000. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 26, 97 – 102. | en_US |
dc.identifier.citedreference | Chua, S.C., Jr, Koutras, I.K., Han, L., Liu, S.M., Kay, J., Young, S.J., Chung, W.K. & Leibel, R.L. 1997. Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts. Genomics 45, 264 – 270. | en_US |
dc.identifier.citedreference | Clark, J.T., Kalra, P.S. & Kalra, S.P. 1985. Neuropeptide Y stimulates feeding but inhibits sexual behavior in rats. Endocrinology 117, 2435 – 2442. | en_US |
dc.identifier.citedreference | Clement, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.M., Basdevant, A., Bougneres, P., leBouc, Y., Froguel, P. & Guy-Grand, B. 1998. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392, 398 – 401. | en_US |
dc.identifier.citedreference | Cota, D., Proulx, K., Smith, K.A., Kozma, S.C., Thomas, G., Woods, S.C. & Seeley, R.J. 2006. Hypothalamic mTOR signaling regulates food intake. Science 312, 927 – 930. | en_US |
dc.identifier.citedreference | Couturier, C. & Jockers, R. 2003. Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers. J Biol Chem 270, 26604 – 26611. | en_US |
dc.identifier.citedreference | Cowley, M.A., Smart, J.L., Rubinstein, M., Cerdan, M.G., Diano, S., Horvath, T.L., Cone, R.D. & Low, M.J. 2001. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411, 480 – 484. | en_US |
dc.identifier.citedreference | Cui, Y., Huang, L., Elefteriou, F., Yang, G., Shelton, J.M., Giles, J.E., Oz, O.K., Pourbahrami, T., Lu, C.Y., Richardson, J.A., Karsenty, G. & Li, C. 2004. Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol 24, 258 – 269. | en_US |
dc.identifier.citedreference | Devos, R., Guisez, Y., Van der Heyden, J., White, D.W., Kalai, M., Fountoulakis, M. & Plaetinck, G. 1997. Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding. J Biol Chem 272, 18304 – 18310. | en_US |
dc.identifier.citedreference | Dhillon, H., Zigman, J.M., Ye, C., Lee, C.E., McGovern, R.A., Tang, V., Kenny, C.D., Christiansen, L.M., White, R.D., Edelstein, E.A. et al. 2006. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49, 191 – 203. | en_US |
dc.identifier.citedreference | DiLeone, R.J., Georgescu, D. & Nestler, E.J. 2003. Lateral hypothalamic neuropeptides in reward and drug addiction. Life Sci 73, 759 – 768. | en_US |
dc.identifier.citedreference | Dunn, S.L., Bjornholm, M., Bates, S.H., Chen, Z., Seifert, M. & Myers, M.G., Jr. 2005. Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol Endocrinol 19, 925 – 938. | en_US |
dc.identifier.citedreference | Ellacott, K.L. & Cone, R.D. 2006. The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models. Philos Trans R Soc Lond B Biol Sci 361, 1265 – 1274. | en_US |
dc.identifier.citedreference | Ellacott, K.L., Halatchev, I.G. & Cone, R.D. 2006a. Characterization of leptin-responsive neurons in the caudal brainstem. Endocrinology 147, 3190 – 3195. | en_US |
dc.identifier.citedreference | Ellacott, K.L., Halatchev, I.G. & Cone, R.D. 2006b. Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasis. Peptides 27, 340 – 349. | en_US |
dc.identifier.citedreference | Elmquist, J.K., Bjorbaek, C., Ahima, R.S., Flier, J.S. & Saper, C.B. 1998a. Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol 395, 535 – 547. | en_US |
dc.identifier.citedreference | Elmquist, J.K., Maratos-Flier, E., Saper, C.B. & Flier, J.S. 1998b. Unraveling the central nervous system pathways underlying responses to leptin. Nat Neurosci 1, 445 – 449. | en_US |
dc.identifier.citedreference | Elmquist, J.K., Coppari, R., Balthasar, N., Ichinose, M. & Lowell, B.B. 2005. Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J Comp Neurol 493, 63 – 71. | en_US |
dc.identifier.citedreference | Erickson, J.C., Hollopeter, G. & Palmiter, R.D. 1996. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274, 1704 – 1707. | en_US |
dc.identifier.citedreference | Feener, E.P., Rosario, F., Dunn, S.L., Stancheva, Z. & Myers, M.G., Jr. 2004. Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. Mol Cell Biol 24, 4968 – 4978. | en_US |
dc.identifier.citedreference | Feng, G.S. 1999. Shp-2 tyrosine phosphatase: signaling one cell or many. Exp Cell Res 253, 47 – 54. | en_US |
dc.identifier.citedreference | Feng, J., Witthuhn, B.A., Matsuda, T., Kohlhuber, F., Kerr, I.M. & Ihle, J.N. 1997. Activation of Jak2 catalytic activity requires phosphorylation of Y 1007 in the kinase activation loop. Mol Cell Biol 17, 2497 – 2501. | en_US |
dc.identifier.citedreference | Figlewicz, D.P. 2003. Adiposity signals and food reward: expanding the CNS roles of insulin and leptin. Am J Physiol Regul Integr Comp Physiol 284, R882 – R892. | en_US |
dc.identifier.citedreference | Figlewicz, D.P., Evans, S.B., Murphy, J., Hoen, M. & Baskin, D.G. 2003. Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat. Brain Res 964, 107 – 115. | en_US |
dc.identifier.citedreference | Figlewicz, D.P., Naleid, A.M. & Sipols, A.J. 2006. Modulation of food reward by adiposity signals. Physiol Behav 91, 473 – 478. | en_US |
dc.identifier.citedreference | Friedman, J.M. & Halaas, J.L. 1998. Leptin and the regulation of body weight in mammals. Nature 395, 763 – 770. | en_US |
dc.identifier.citedreference | Fulton, S., Woodside, B. & Shizgal, P. 2000. Modulation of brain reward circuitry by leptin. Science 287, 125 – 128. | en_US |
dc.identifier.citedreference | Fulton, S., Richard, D., Woodside, B. & Shizgal, P. 2004. Food restriction and leptin impact brain reward circuitry in lean and obese Zucker rats. Behav Brain Res 155, 319 – 329. | en_US |
dc.identifier.citedreference | Fulton, S., Pissios, P., Manchon, R.P., Stiles, L., Frank, L., Pothos, E.N., Maratos-Flier, E. & Flier, J.S. 2006. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 51, 811 – 822. | en_US |
dc.identifier.citedreference | Funakoshi-Tago, M., Pelletier, S., Matsuda, T., Parganas, E. & Ihle, J.N. 2006. Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2. EMBO J 25, 4763 – 4772. | en_US |
dc.identifier.citedreference | Ge, H., Huang, L., Pourbahrami, T. & Li, C. 2002. Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. J Biol Chem 277, 45898 – 45903. | en_US |
dc.identifier.citedreference | Gong, Y., Ishida-Takahashi, R., Villanueva, E.C., Fingar, D.C., MÜnzberg, H. & Myers, M.G., Jr. 2007. The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J Biol Chem 282, 31019 – 31027. | en_US |
dc.identifier.citedreference | Grill, H.J. 2006. Distributed neural control of energy balance: contributions from hindbrain and hypothalamus. Obesity (Silver Spring) 14 ( Suppl. 5 ), 216S – 221S. | en_US |
dc.identifier.citedreference | Grill, H.J., Schwartz, M.W., Kaplan, J.M., Foxhall, J.S., Breininger, J. & Baskin, D.G. 2002. Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake. Endocrinology 143, 239 – 246. | en_US |
dc.identifier.citedreference | Haan, S., Hemmann, U., Hassiepen, U., Schaper, F., Schneider-Mergener, J., Wollmer, A., Heinrich, P.C. & Grotzinger, J. 1999. Characterization and binding specificity of the monomeric STAT3-SH2 domain. J Biol Chem 274, 1342 – 1348. | en_US |
dc.identifier.citedreference | Harris, G.C., Wimmer, M. & Aston-Jones, G. 2005. A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437, 556 – 559. | en_US |
dc.identifier.citedreference | Hekerman, P., Zeidler, J., Bamberg-Lemper, S., Knobelspies, H., Lavens, D., Tavernier, J., Joost, H.G. & Becker, W. 2005. Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines. FEBS J 272, 109 – 119. | en_US |
dc.identifier.citedreference | Hommel, J.D., Trinko, R., Sears, R.M., Georgescu, D., Liu, Z.W., Gao, X.B., Thurmon, J.J., Marinelli, M. & DiLeone, R.J. 2006. Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron 51, 801 – 810. | en_US |
dc.identifier.citedreference | Howard, J.K., Cave, B.J., Oksanen, L.J., Tzameli, I., Bjorbaek, C. & Flier, J.S. 2004. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 10, 734 – 738. | en_US |
dc.identifier.citedreference | Huo, L., Maeng, L., Bjorbaek, C. & Grill, H.J. 2007. Leptin and the control of food intake: neurons in the nucleus of the solitary tract are activated by both gastric distension and leptin. Endocrinology 148, 2189 – 2197. | en_US |
dc.identifier.citedreference | Huszar, D., Lynch, C.A., Fairchild-Huntress, V., Dunmore, J.H., Fang, Q., Berkemeier, L.R., Gu, W., Kesterson, R.A., Boston, B.A., Cone, R.D., Smith, F.J., Campfield, L.A., Burn, P. & Lee, F. 1997. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131 – 141. | en_US |
dc.identifier.citedreference | Ihle, J.N. & Kerr, I.M. 1995. Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet 11, 69 – 74. | en_US |
dc.identifier.citedreference | Ishida-Takahashi, R., Rosario, F., Gong, Y., Kopp, K., Stancheva, Z., Chen, X., Feener, E.P. & Myers, M.G., Jr. 2006. Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling. Mol Cell Biol 26, 4063 – 4073. | en_US |
dc.identifier.citedreference | Kaelin, C.B., Gong, L., Xu, A.W., Yao, F., Hockman, K., Morton, G.J., Schwartz, M.W., Barsh, G.S. & MacKenzie, R.G. 2006. Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acid. Mol Endocrinol 20, 2591 – 2602. | en_US |
dc.identifier.citedreference | Keilhack, H., David, F.S., McGregor, M., Cantley, L.C. & Neel, B.G. 2005. Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes. J Biol Chem 280, 30984 – 30993. | en_US |
dc.identifier.citedreference | Kelley, A.E. & Berridge, K.C. 2002. The neuroscience of natural rewards: relevance to addictive drugs. J Neurosci 22, 3306 – 3311. | en_US |
dc.identifier.citedreference | Kloek, C., Haq, A.K., Dunn, S.L., Lavery, H.J., Banks, A.S. & Myers, M.G., Jr. 2002. Regulation of Jak kinases by intracellular leptin receptor sequences. J Biol Chem 277, 41547 – 41555. | en_US |
dc.identifier.citedreference | Koch, C.A., Anderson, D.J., Moran, M.F., Ellis, C.A. & Pawson, T. 1991. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 252, 668 – 674. | en_US |
dc.identifier.citedreference | Kurzer, J.H., Argetsinger, L.S., Zhou, Y.J., Kouadio, J.L., O’Shea, J.J. & Carter-Su, C. 2004. Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta. Mol Cell Biol 24, 4557 – 4570. | en_US |
dc.identifier.citedreference | Leshan, R.L., Bjornholm, M., Munzberg, H. & Myers, M.G., Jr. 2006. Leptin receptor signaling and action in the central nervous system. Obesity (Silver Spring) 14 ( Suppl. 5 ), 208S – 212S. | en_US |
dc.identifier.citedreference | Li, C. & Friedman, J.M. 1999. Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc Natl Acad Sci USA 96, 9677 – 9682. | en_US |
dc.identifier.citedreference | Lord, G.M., Matarese, G., Howard, J.K., Baker, R.J., Bloom, S.R. & Lechler, R.I. 1998. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394, 897 – 901. | en_US |
dc.identifier.citedreference | MacNeil, D.J., Howard, A.D., Guan, X., Fong, T.M., Nargund, R.P., Bednarek, M.A., Goulet, M.T., Weinberg, D.H., Strack, A.M., Marsh, D.J. et al. 2002. The role of melanocortins in body weight regulation: opportunities for the treatment of obesity. Eur J Pharmacol 450, 93 – 109. | en_US |
dc.identifier.citedreference | Marsh, D.J., Hollopeter, G., Huszar, D., Laufer, R., Yagaloff, K.A., Fisher, S.L., Burn, P. & Palmiter, R.D. 1999. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 21, 119 – 122. | en_US |
dc.identifier.citedreference | Matsuda, T., Feng, J., Witthuhn, B.A., Sekine, Y. & Ihle, J.N. 2004. Determination of the transphosphorylation sites of Jak2 kinase. Biochem Biophys Res Commun 325, 586 – 594. | en_US |
dc.identifier.citedreference | Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferre, P., Birnbaum, M.J., Stuck, B.J. & Kahn, B.B. 2004. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428, 569 – 574. | en_US |
dc.identifier.citedreference | Montague, C.T., Farooqi, I.S., Whitehead, J.P., Soos, M.S., Rau, H., Wareham, N.J., Sewter, C.P., Digby, J.E., Mohammed, S.N., Hurst, J.A., Cheetham, C.H., Early, A.R., Barnett, A.H., Prins, J.B. & O’Rahilly, S. 1997. Congenital leptin deficiency is associated with severe early onset obesity in humans. Nature 387, 903 – 908. | en_US |
dc.identifier.citedreference | Mori, H., Hanada, R., Hanada, T., Aki, D., Mashima, R., Nishinakamura, H., Torisu, T., Chien, K.R., Yasukawa, H. & Yoshimura, A. 2004. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med 10, 739 – 743. | en_US |
dc.identifier.citedreference | Morton, G.J., Niswender, K.D., Rhodes, C.J., Myers, M.G., Jr, Blevins, J.T., Baskin, D.G. & Schwartz, M.W. 2003. Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fak/fak) rats. Endocrinology 144, 2016 – 2024. | en_US |
dc.identifier.citedreference | Morton, G.J., Blevins, J.E., Williams, D.L., Niswender, K.D., Gelling, R.W., Rhodes, C.J., Baskin, D.G. & Schwartz, M.W. 2005. Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest 115, 703 – 710. | en_US |
dc.identifier.citedreference | Morton, G.J., Cummings, D.E., Baskin, D.G., Barsh, G.S. & Schwartz, M.W. 2006. Central nervous system control of food intake and body weight. Nature 443, 289 – 295. | en_US |
dc.identifier.citedreference | Munzberg, H., Huo, L., Nillni, E.A., Hollenberg, A.N. & Bjorbaek, C. 2003. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology 144, 2121 – 2131. | en_US |
dc.identifier.citedreference | Munzberg, H., Jobst, E.E., Bates, S.H., Jones, J., Villanueva, E., Leshan, R., Bjornholm, M., Elmquist, J., Sleeman, M., Cowley, M.A. & Myers, M.G., Jr. 2007. Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling. J Neurosci 27, 69 – 74. | en_US |
dc.identifier.citedreference | Nestler, E.J. 2005. Is there a common molecular pathway for addiction? Nat Neurosci 8, 1445 – 1449. | en_US |
dc.identifier.citedreference | Niswender, K.D., Morton, G.J., Stearns, W.H., Rhodes, C.J., Myers, M.G., Jr & Schwartz, M.W. 2001. Intracellular signalling key enzyme in leptin-induced anorexia. Nature 413, 794 – 795. | en_US |
dc.identifier.citedreference | Ollmann, M.M., Wilson, B.D., Yang, Y.K., Kerns, J.A., Chen, Y., Gantz, I. & Barsh, G.S. 1997. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135 – 138. | en_US |
dc.identifier.citedreference | Pinto, S., Roseberry, A.G., Liu, H., Diano, S., Shanabrough, M., Cai, X., Friedman, J.M. & Horvath, T.L. 2004. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304, 110 – 115. | en_US |
dc.identifier.citedreference | Plum, L., Ma, X., Hampel, B., Balthasar, N., Coppari, R., Munzberg, H., Shanabrough, M., Burdakov, D., Rother, E., Janoschek, R. et al. 2006. Enhanced PIP(3) signaling in POMC neurons causes K(ATP) channel activation and leads to diet-sensitive obesity. J Clin Invest 116, 1886 – 1901. | en_US |
dc.identifier.citedreference | Qu, D., Ludwig, D.S., Gammeltoft, S., Piper, M., Pelleymounter, M.A., Cullen, M.J., Mathes, W.F., Przypek, J., Kanarek, R. & Maratos-Flier, E. 1996. A role for melanin-concentrating hormone in the central regulation of feeding behavior. Nature 380, 243 – 247. | en_US |
dc.identifier.citedreference | Sasaki, A., Yasukawa, H., Shouda, T., Kitamura, T., Dikic, I. & Yoshimura, A. 2000. CIS3/SOCS3 suppresses erythropoietin signaling by binding the EPO receptor and JAK2. J Biol Chem 275, 29338 – 29347. | en_US |
dc.identifier.citedreference | Smith, M.A., Hisadome, K., Al Qassab, H., Heffron, H., Withers, D.J. & Ashford, M.L. 2007. Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances. J Physiol 578 ( Pt 2 ), 425 – 438. | en_US |
dc.identifier.citedreference | Songyang, Z., Shoelson, S.E., Chaudhuri, M., Gish, G.D., Pawson, T., Haser, W.G., King, F., Roberts, T., Ratnofsky, S., Lechleider, R.J. et al. 1993. SH2 domains recognize specific phosphopeptide sequences. Cell 72, 767 – 778. | en_US |
dc.identifier.citedreference | Ste, M.L., Miura, G.I., Marsh, D.J., Yagaloff, K. & Palmiter, R.D. 2000. A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proc Natl Acad Sci USA 97, 12339 – 12344. | en_US |
dc.identifier.citedreference | Sternson, S.M., Shepherd, G.M. & Friedman, J.M. 2005. Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fasting. Nat Neurosci 8, 1356 – 1363. | en_US |
dc.identifier.citedreference | Taga, T. & Kishimoto, T. 1997. gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 15, 797 – 819. | en_US |
dc.identifier.citedreference | Taniguchi, T. 1995. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268, 251 – 255. | en_US |
dc.identifier.citedreference | Tartaglia, L.A. 1997. The leptin receptor. J Biol Chem 272, 6093 – 6096. | en_US |
dc.identifier.citedreference | White, D.W., Kuropatwinski, K.K., Devos, R., Baumann, H. & Tartaglia, L.A. 1997. Leptin receptor (OB-R) signaling. J Biol Chem 272, 4065 – 4071. | en_US |
dc.identifier.citedreference | Williams, D.L., Baskin, D.G. & Schwartz, M.W. 2006. Leptin regulation of the anorexic response to glucagon-like peptide-1 receptor stimulation. Diabetes 55, 3387 – 3393. | en_US |
dc.identifier.citedreference | Xu, A.W., Kaelin, C.B., Takeda, K., Akira, S., Schwartz, M.W. & Barsh, G.S. 2005. PI3K integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest 115, 951 – 958. | en_US |
dc.identifier.citedreference | Xu, A.W., Ste-Marie, L., Kaelin, C.B. & Barsh, G.S. 2006. Inactivation of Stat3 in Pomc neurons causes decreased Pomc expression, mild obesity and defects in compensatory refeeding. Endocrinology 148, 72 – 80. | en_US |
dc.identifier.citedreference | Yamanaka, A., Beuckmann, C.T., Willie, J.T., Hara, J., Tsujino, N., Mieda, M., Tominaga, M., Yagami, K., Sugiyama, F., Goto, K., Yanagisawa, M. & Sakurai, T. 2003. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 38, 701 – 713. | en_US |
dc.identifier.citedreference | Zhang, E.E., Chapeau, E., Hagihara, K. & Feng, G.S. 2004. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci USA 101, 16064 – 16069. | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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