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Cluster designation 5 staining of normal and non-lymphoid neoplastic skin *

dc.contributor.authorBogner, Paul N.en_US
dc.contributor.authorSu, Lyndon D.en_US
dc.contributor.authorFullen, Douglas R.en_US
dc.date.accessioned2010-06-01T18:35:09Z
dc.date.available2010-06-01T18:35:09Z
dc.date.issued2005-01en_US
dc.identifier.citationBogner, Paul N.; Su, Lyndon D.; Fullen, Douglas R. (2005). "Cluster designation 5 staining of normal and non-lymphoid neoplastic skin * ." Journal of Cutaneous Pathology 32(1): 50-54. <http://hdl.handle.net/2027.42/71788>en_US
dc.identifier.issn0303-6987en_US
dc.identifier.issn1600-0560en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/71788
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15660655&dopt=citationen_US
dc.description.abstractImmunohistochemical staining for cluster designation 5 (CD5) has been found to label a variety of non-lymphoid tumors. Methods:  A variety of eccrine, apocrine, follicular, epithelial, and pagetoid lesions were selected and stained with an anti-CD5 monoclonal antibody (Novocastra Labs, Newcastle upon Tyne, UK, clone 4C7) by immunohistochemistry. The intensity of positive cytoplasmic staining was graded semiquantitatively (1+ weak staining, 2+ strong staining). Additionally, the percentage of positive lesional cells was placed in one of four categories: >75%, 25–75%, 1–25%, and <1%. Results:  Within normal skin, CD5 labeled lymphocytes, apocrine glands, deep dermal eccrine glands, and smooth muscle (weak). The majority of benign and malignant apocrine lesions demonstrated strong focal (36%, n = 11)-to-diffuse (64%, n = 16) staining. In contrast, labeling of benign eccrine tumors was more focal, tending to localize around ducts (79%, n = 19). Microcystic adnexal carcinoma demonstrated focal staining of deeper ductal structures (71%, n = 7), whereas desmoplastic trichoepithelioma and basal cell carcinoma showed only rare positive cells. All cases of mammary (n = 7) and extramammary (n = 8) Paget's disease labeled diffusely for CD5. Pagetoid Bowen's disease (n = 6), intraepidermal sebaceous carcinoma (n = 3), nor melanoma in situ (n = 6) showed any CD5 staining. Conclusions:  Immunohistochemical staining for CD5 is extremely useful in the differential diagnosis of pagetoid epidermal lesions and will mark mammary and extramammary Paget's disease, but not pagetoid Bowen's disease, melanoma in situ , or sebaceous carcinoma. Bogner PN, Su LD, Fullen DR. Cluster designation 5 staining of normal and non-lymphoid neoplastic skin.en_US
dc.format.extent4321730 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherMunksgaard International Publishersen_US
dc.publisherBlackwell Publishing Ltden_US
dc.rightsBlackwell Munksgaard, 2005en_US
dc.titleCluster designation 5 staining of normal and non-lymphoid neoplastic skin *en_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelDermatologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Dermatology, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherDepartment of Pathology, anden_US
dc.identifier.pmid15660655en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/71788/1/j.0303-6987.2005.00253.x.pdf
dc.identifier.doi10.1111/j.0303-6987.2005.00253.xen_US
dc.identifier.sourceJournal of Cutaneous Pathologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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