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Sino-Orbital and Cerebral Aspergillosis: Cure with Medical Therapy/Sino-Orbital- und Zerebralaspergillose: Ausheilung durch medikamentÖse Therapie

dc.contributor.authorBradley, Suzanne F.en_US
dc.contributor.authorMcGuire, Nancy M.en_US
dc.contributor.authorKauffman, Carol A.en_US
dc.date.accessioned2010-06-01T18:44:05Z
dc.date.available2010-06-01T18:44:05Z
dc.date.issued1987-08en_US
dc.identifier.citationBradley, Suzanne F.; McGuire, Nancy M.; Kauffman, Carol A. (1987). "Sino-Orbital and Cerebral Aspergillosis: Cure with Medical Therapy/Sino-Orbital- und Zerebralaspergillose: Ausheilung durch medikamentÖse Therapie." Mycoses 30(8): 379-385. <http://hdl.handle.net/2027.42/71932>en_US
dc.identifier.issn0933-7407en_US
dc.identifier.issn1439-0507en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/71932
dc.description.abstractA patient with sino-orbital and cerebral aspergillosis was successfully treated medically without surgical debridement. Anti-fungal agents, including amphotericin B and flucytosine were given over a fifteen month period with improvement in symptoms, resolution of cerebral abscesses by CT scan, and disappearance of serum precipitins to Aspergillus fumigatus. Success was attributed to the long duration of therapy (received in part as an outpatient), the use of agents to which the organism was known to be susceptible, and the maintenance of therapeutic drug levels. Although surgery is important in the management of chronic sino-orbital and cerebral aspergillosis, in patients unable to undergo extensive debridement medical therapy given for extended periods of time may be successful in eradicating the infection. Zusammenfassung : Eine Patientin mit einer Aspergillose der NebenhÖhlen, der Orbita und des Gehirns wurde erfolgreich medikamentÖs ohne chirurgisches Debridement behandelt. Antimykotika einschließlich Amphotericin B und Flucytosin wurden Über einen Zeitraum von 15 Monaten verabreicht und fÜhrten zu einer Besserung der Symptomatik zu einer RÜckbildung der computertomographisch erfaßbaren zerebralen Abszesse und zu einem Verschwinden der SerumprÄzipitine gegen Aspergillus fumigatus. Der Erfolg wird der langen Dauer der antimykotischen Chemotherapie zugeschrieben (teilweise ambulant verabreicht), ferner der Anwendung von PrÄparaten mit ausgetesteter SuszeptibilitÄt des Erregers und der Erzielung und Erhaltung therapeutisch wirksamer Antimykotika-Konzentrationen. Obgleich die Chirurgie in der Behandlung der Aspergillose der NebenhÖhlen, der Orbita und des Gehirns das Vorgehen der ersten Wahl ist, kann die medikamentÖse Therapie bei Patienten, an denen ein extensives chirurgisches Debridement nicht mÖglich ist, bei Langzeitanwendung die Infektion zum ErlÖschen bringen.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1987 Blackwell Verlag GmbHen_US
dc.subject.otherAspergillosisen_US
dc.subject.otherAspergillus Fumigatusen_US
dc.subject.otherSino-orbitalen_US
dc.subject.otherCerebralen_US
dc.subject.otherAspergilloseen_US
dc.subject.otherAspergillus Fumigatusen_US
dc.subject.otherNebenhÖHlenen_US
dc.subject.otherOrbitaen_US
dc.subject.otherGehirnen_US
dc.titleSino-Orbital and Cerebral Aspergillosis: Cure with Medical Therapy/Sino-Orbital- und Zerebralaspergillose: Ausheilung durch medikamentÖse Therapieen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelDentistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Infectious Diseases, Department of Internal Medicine, Veterans Administration Medical Center, University of Michigan Medical School, Ann Arbor, Michigan, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/71932/1/j.1439-0507.1987.tb03632.x.pdf
dc.identifier.doi10.1111/j.1439-0507.1987.tb03632.xen_US
dc.identifier.sourceMycosesen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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