Effects of acute hyperglycaemia on anorectal motor and sensory function in diabetes mellitus
dc.contributor.author | Russo, A. | en_US |
dc.contributor.author | Botten, R. | en_US |
dc.contributor.author | Kong, M. -F. | en_US |
dc.contributor.author | Chapman, I. M. | en_US |
dc.contributor.author | Fraser, R. J. L. | en_US |
dc.contributor.author | Horowitz, M. | en_US |
dc.contributor.author | Sun, W.-M. | en_US |
dc.date.accessioned | 2010-06-01T18:46:32Z | |
dc.date.available | 2010-06-01T18:46:32Z | |
dc.date.issued | 2004-02 | en_US |
dc.identifier.citation | Russo, A.; Botten, R.; Kong, M.-F.; Chapman, I. M.; Fraser, R. J. L.; Horowitz, M.; Sun, W.-M. (2004). "Effects of acute hyperglycaemia on anorectal motor and sensory function in diabetes mellitus." Diabetic Medicine 21(2): 176-182. <http://hdl.handle.net/2027.42/71972> | en_US |
dc.identifier.issn | 0742-3071 | en_US |
dc.identifier.issn | 1464-5491 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/71972 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14984454&dopt=citation | en_US |
dc.description.abstract | Aims To determine the effects of acute hyperglycaemia on anorectal motor and sensory function in patients with diabetes mellitus. Methods In eight patients with Type 1, and 10 patients with Type 2 diabetes anorectal motility and sensation were evaluated on separate days while the blood glucose concentration was stabilized at either 5 mmol/l or 12 mmol/l using a glucose clamp technique. Eight healthy subjects were studied under euglycaemic conditions. Anorectal motor and sensory function was evaluated using a sleeve/sidehole catheter, incorporating a barostat bag. Results In diabetic subjects hyperglycaemia was associated with reductions in maximal ( P < 0.05) and plateau ( P < 0.05) anal squeeze pressures and the rectal pressure/volume relationship (compliance) during barostat distension ( P < 0.01). Hyperglycaemia had no effect on the perception of rectal distension. Apart from a reduction in rectal compliance ( P < 0.01) and a trend ( P = 0.06) for an increased number of spontaneous anal sphincter relaxations, there were no differences between the patients studied during euglycaemia when compared with healthy subjects. Conclusions In patients with diabetes, acute hyperglycaemia inhibits external anal sphincter function and decreases rectal compliance, potentially increasing the risk of faecal incontinence. Diabet. Med. 21, 176–182 (2004) | en_US |
dc.format.extent | 147523 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd. | en_US |
dc.rights | © 2004 Diabetes UK. | en_US |
dc.subject.other | Anorectal Motility | en_US |
dc.subject.other | Hyperglycaemia | en_US |
dc.subject.other | Faecal Incontinence | en_US |
dc.title | Effects of acute hyperglycaemia on anorectal motor and sensory function in diabetes mellitus | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | † Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, | en_US |
dc.contributor.affiliationother | * Department of Diabetes & Endocrinology, Leicester General Hospital, Leicester, UK, and | en_US |
dc.identifier.pmid | 14984454 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/71972/1/j.1464-5491.2004.01106.x.pdf | |
dc.identifier.doi | 10.1111/j.1464-5491.2004.01106.x | en_US |
dc.identifier.source | Diabetic Medicine | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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