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The Role of a Bioengineered Artificial Kidney in Renal Failure

dc.contributor.authorFissell, William H.en_US
dc.contributor.authorKimball, Jasonen_US
dc.contributor.authorMackay, Sherrill M.en_US
dc.contributor.authorFunke, Angela J.en_US
dc.contributor.authorHumes, H. Daviden_US
dc.date.accessioned2010-06-01T18:47:59Z
dc.date.available2010-06-01T18:47:59Z
dc.date.issued2001-11en_US
dc.identifier.citationFISSELL, WILLIAM H.; KIMBALL, JASON; MACKAY, SHERRILL M.; FUNKE, ANGELA; HUMES, H. DAVID (2001). "The Role of a Bioengineered Artificial Kidney in Renal Failure." Annals of the New York Academy of Sciences 944(1 BIOARTIFICIAL ORGANS III: TISSUE SOURCING, IMMUNOISOLATION, AND CLINICAL TRIALS ): 284-295. <http://hdl.handle.net/2027.42/71995>en_US
dc.identifier.issn0077-8923en_US
dc.identifier.issn1749-6632en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/71995
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11797678&dopt=citationen_US
dc.description.abstractRenal failure continues to carry substantial burden of morbidity and mortality in both acute and chronic forms, despite advances in transplantation and dialysis. There is evidence to suggest that the kidney has metabolic, endocrine, and immune effects transcending its filtration functions, even beyond secretion of renin and erythropoietin. Our laboratory has developed experience in the tissue culture of renal parenchymal cells, and has now been able to demonstrate the metabolic activity of these cells in an extracorporeal circuit recapitulating glomerulotubular anatomy. We have observed active transport of sodium, glucose, and glutathione. We describe the design and initial preclinical testing of the bioartificial kidney, as well as future directions of our research.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights2001 by the New York Academy of Sciencesen_US
dc.subject.otherBioengineeringen_US
dc.subject.otherArtificial Kidneyen_US
dc.subject.otherRenal Failureen_US
dc.titleThe Role of a Bioengineered Artificial Kidney in Renal Failureen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelScience (General)en_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Internal Medicine, VA Medical Center and University of Michigan, Ann Arbor, Michigan, USAen_US
dc.identifier.pmid11797678en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/71995/1/j.1749-6632.2001.tb03841.x.pdf
dc.identifier.doi10.1111/j.1749-6632.2001.tb03841.xen_US
dc.identifier.sourceAnnals of the New York Academy of Sciencesen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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