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Stem cells in normal breast development and breast cancer

dc.contributor.authorDontu, Gabrielaen_US
dc.contributor.authorAl-Hajj, Muhammaden_US
dc.contributor.authorAbdallah, Wissam M.en_US
dc.contributor.authorClarke, Michael F.en_US
dc.contributor.authorWicha, Max S.en_US
dc.date.accessioned2010-06-01T18:59:32Z
dc.date.available2010-06-01T18:59:32Z
dc.date.issued2003-10en_US
dc.identifier.citationDontu, Gabriela; Al-Hajj, Muhammad; Abdallah, Wissam M.; Clarke, Michael F.; Wicha, Max S. (2003). "Stem cells in normal breast development and breast cancer." Cell Proliferation 36(s1): 59-72. <http://hdl.handle.net/2027.42/72182>en_US
dc.identifier.issn0960-7722en_US
dc.identifier.issn1365-2184en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72182
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14521516&dopt=citationen_US
dc.description.abstractThe main focus of this review is the role of mammary stem cells in normal breast development and carcinogenesis. We have developed a new in vitro culture system that permits, for the first time, the propagation of mammary stem and progenitor cells in an undifferentiated state, which should facilitate the elucidation of pathways that regulate normal mammary stem-cell self-renewal and differentiation. Furthermore, we propose a model in which transformation of stem cells, or early progenitor cells, results in carcinogenesis. A key event in this process is the deregulation of normal self-renewal in these cells. Transformed mammary stem or progenitor cells undergo aberrant differentiation processes that result in generation of the phenotypic heterogeneity found in human and rodent breast cancers. This phenotypic diversity is driven by a small subset of mammary tumour stem cells. We will discuss the important implications of this mammary tumour stem-cell model.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltd.en_US
dc.rights© 2003 Blackwell Publishing Ltd.en_US
dc.titleStem cells in normal breast development and breast canceren_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, Hematology-Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USAen_US
dc.identifier.pmid14521516en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72182/1/j.1365-2184.36.s.1.6.x.pdf
dc.identifier.doi10.1046/j.1365-2184.36.s.1.6.xen_US
dc.identifier.sourceCell Proliferationen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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