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Efficacy of cyclosporin A in psoriasis: a summary of the United States’ experience

dc.contributor.authorFradin, M. S.en_US
dc.contributor.authorEllis, C. N.en_US
dc.contributor.authorVoorhees, John J.en_US
dc.date.accessioned2010-06-01T19:08:39Z
dc.date.available2010-06-01T19:08:39Z
dc.date.issued1990-06en_US
dc.identifier.citationFRADIN, M.S.; ELLIS, C.N.; VOORHEES, J.J. (1990). "Efficacy of cyclosporin A in psoriasis: a summary of the United States’ experience." British Journal of Dermatology 122(): 21-25. <http://hdl.handle.net/2027.42/72330>en_US
dc.identifier.issn0007-0963en_US
dc.identifier.issn1365-2133en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72330
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2196080&dopt=citationen_US
dc.description.abstractSince its discovery in 1972, cyclosporin A (CyA) has been widely used in the experimental treatment of multiple inflammatory diseases considered to be of immune-mediated aetiology. In dermatology, oral CyA is most effective in the treatment of psoriasis and has been used successfully for plaque-type, pustular and erythrodermic forms of the disease. While dosages ranging from 1 to 14 mg/kg/day have been used, a starting dose of 4 mg/kg/day gives a rapid response with few side-effects. Nephrotoxicity remains the greatest concern in long-term use of the drug. Although intralesional CyA has proven effective in psoriasis, topical preparations have not. It is hoped that future research will provide effective topical formulations of CyA which are efficacious without the risks inherent in systemic administration.en_US
dc.format.extent357792 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1990 British Association of Dermatologistsen_US
dc.titleEfficacy of cyclosporin A in psoriasis: a summary of the United States’ experienceen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelDermatologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.en_US
dc.identifier.pmid2196080en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72330/1/j.1365-2133.1990.tb02878.x.pdf
dc.identifier.doi10.1111/j.1365-2133.1990.tb02878.xen_US
dc.identifier.sourceBritish Journal of Dermatologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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