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Regulators of G protein signaling (RGS proteins): Novel central nervous system drug targets

dc.contributor.authorNeubig, Richard R.en_US
dc.date.accessioned2010-06-01T19:25:27Z
dc.date.available2010-06-01T19:25:27Z
dc.date.issued2002-12en_US
dc.identifier.citationNeubig, R. R. (2002). "Regulators of G protein signaling (RGS proteins): Novel central nervous system drug targets." The Journal of Peptide Research 60(6): 312-316. <http://hdl.handle.net/2027.42/72565>en_US
dc.identifier.issn1397-002Xen_US
dc.identifier.issn1399-3011en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72565
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12464108&dopt=citationen_US
dc.description.abstractMany drugs of abuse signal through receptors that couple to G proteins (GPCRs), so the factors that control GPCR signaling are likely to be important to the understanding of drug abuse. Contributions by the recently identified protein family, regulators of G protein signaling (RGS) to the control of GPCR function are just beginning to be understood. RGS proteins can accelerate the deactivation of G proteins by 1000-fold and in cell systems they profoundly inhibit signaling by many receptors, including mu-opioid receptors. Coupled with the known dynamic regulation of RGS protein expression and function, they are of obvious interest in understanding tolerance and dependence mechanisms. Furthermore, drugs that could inhibit their activity could be useful in preventing the development of or in treating drug dependence.en_US
dc.format.extent66305 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherMunksgaard International Publishersen_US
dc.publisherBlackwell Publishing Ltden_US
dc.rights2002 Blackwell Munksgaarden_US
dc.titleRegulators of G protein signaling (RGS proteins): Novel central nervous system drug targetsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Pharmacology and Internal Medicine/Hypertension, The University of Michigan, Ann Arbor, USA.en_US
dc.identifier.pmid12464108en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72565/1/j.1399-3011.2002.21064.x.pdf
dc.identifier.doi10.1034/j.1399-3011.2002.21064.xen_US
dc.identifier.sourceThe Journal of Peptide Researchen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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