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Intracellular NOD-like receptors in innate immunity, infection and disease

dc.contributor.authorFranchi, Luigien_US
dc.contributor.authorPark, Jong-Hwanen_US
dc.contributor.authorShaw, Michael H.en_US
dc.contributor.authorMarina-Garcia, Noemien_US
dc.contributor.authorChen, Graceen_US
dc.contributor.authorKim, Yun-Gien_US
dc.contributor.authorNúñez, Gabrielen_US
dc.date.accessioned2010-06-01T19:31:30Z
dc.date.available2010-06-01T19:31:30Z
dc.date.issued2008-01en_US
dc.identifier.citationFranchi, Luigi; Park, Jong-Hwan; Shaw, Michael H.; Marina-Garcia, Noemi; Chen, Grace; Kim, Yun-Gi; NÚÑez, Gabriel (2008). "Intracellular NOD-like receptors in innate immunity, infection and disease." Cellular Microbiology 10(1): 1-8. <http://hdl.handle.net/2027.42/72662>en_US
dc.identifier.issn1462-5814en_US
dc.identifier.issn1462-5822en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/72662
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17944960&dopt=citationen_US
dc.description.abstractThe innate immune system comprises several classes of pattern-recognition receptors, including Toll-like receptors (TLRs) and nucleotide binding and oligomerization domain-like receptors (NLRs). TLRs recognize microbes on the cell surface and in endosomes, whereas NLRs sense microbial molecules in the cytosol. In this review, we focus on the role of NLRs in host defence against bacterial pathogens. Nod1 and Nod2 sense the cytosolic presence of molecules containing meso-diaminopimelic acid and muramyl dipeptide respectively, and drive the activation of mitogen-activated protein kinase and NF-κB. In contrast, Ipaf, Nalp1b and Cryopyrin/Nalp3 promote the assembly of inflammasomes that are required for the activation of caspase-1. Mutation in several NLR members, including NOD2 and Cryopyrin, is associated with the development of inflammatory disorders. Further understanding of NLRs should provide new insights into the mechanisms of host defence and the pathogenesis of inflammatory diseases.en_US
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dc.publisherBlackwell Publishing Ltden_US
dc.rights© 2007 The Authors; Journal compilation © 2007 Blackwell Publishing Ltden_US
dc.titleIntracellular NOD-like receptors in innate immunity, infection and diseaseen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid17944960en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/72662/1/j.1462-5822.2007.01059.x.pdf
dc.identifier.doi10.1111/j.1462-5822.2007.01059.xen_US
dc.identifier.sourceCellular Microbiologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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