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Effect of High Dose Spironolactone and Chlorthalidone in Essential Hypertension: Relation to Plasma Renin Activity and Plasma Volume

dc.contributor.authorHunyor, Stephen N.en_US
dc.contributor.authorZweifler, Andrew J.en_US
dc.contributor.authorHansson, Lennarten_US
dc.contributor.authorSchork, M. Anthonyen_US
dc.contributor.authorEllis, Charles N.en_US
dc.date.accessioned2010-06-01T20:17:33Z
dc.date.available2010-06-01T20:17:33Z
dc.date.issued1975-02en_US
dc.identifier.citationHunyor, Stephen N.; Zweifler, Andrew J.; Hansson, Lennart; Schork, M. Anthony; Ellis, Charles (1975). "Effect of High Dose Spironolactone and Chlorthalidone in Essential Hypertension: Relation to Plasma Renin Activity and Plasma Volume." Internal Medicine Journal 5(1): 17-24. <http://hdl.handle.net/2027.42/73411>en_US
dc.identifier.issn1444-0903en_US
dc.identifier.issn1445-5994en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/73411
dc.description.abstractThe effect on blood pressure of high (400 mg/day-S400) and moderate dose (200 mg/day-S200) spironolactone and chlorthalidone (100 mg/day—C100), given in a random double-blind manner was related to plasma renin activity and plasma volume in 38 essential hypertensives. The fall in pressure from a control of 154/103 mm Hg was essentially the same after four weeks of each drug—S400 ABP 24/13 mm, S200 18/9 mm, C100 17/12 mm (all P < 0–001). Twelve of 37 patients (32%) had low initial renin, but this appeared as responsive to the chlorthalidone stimulus as that of the normal renin group. The anti-hypertensive effect of all regimens was unrelated to plasma renin activity. Plasma volume was significantly lowered at the end of each treatment period, but the decline could not be correlated with blood pressure effects. Patients with initially low plasma volume were more likely to respond to S400 ( r = 0.545, P < 0.01), whereas the anti-hypertensive effect of the S200 and C100 regimens was independent of this variable.en_US
dc.format.extent667769 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1975 Published on behalf of the Adult Medicine Division of the Royal Australasian College of Physiciansen_US
dc.titleEffect of High Dose Spironolactone and Chlorthalidone in Essential Hypertension: Relation to Plasma Renin Activity and Plasma Volumeen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumFrom: Hypertension Research, Department of Internal Medicine, University of Michigan, Ann Arbor, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/73411/1/j.1445-5994.1975.tb03249.x.pdf
dc.identifier.doi10.1111/j.1445-5994.1975.tb03249.xen_US
dc.identifier.sourceInternal Medicine Journalen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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