Resuscitation of Severe Uncontrolled Hemorrhage 7.5% Sodium Chloride/6% Dextran 70 vs 0.9% Sodium Chloride
dc.contributor.author | Stern, Susan A. | en_US |
dc.contributor.author | Jwayyed, Sharhabeel | en_US |
dc.contributor.author | Dronen, Steven C. | en_US |
dc.contributor.author | Wang, Xu | en_US |
dc.date.accessioned | 2010-06-01T20:30:53Z | |
dc.date.available | 2010-06-01T20:30:53Z | |
dc.date.issued | 2000-08 | en_US |
dc.identifier.citation | Stern, Susan A.; Jwayyed, Sharhabeel; Dronen, Steven C.; Wang, XU (2000). "Resuscitation of Severe Uncontrolled Hemorrhage 7.5% Sodium Chloride/6% Dextran 70 vs 0.9% Sodium Chloride." Academic Emergency Medicine 7(8): 847-856. <http://hdl.handle.net/2027.42/73625> | en_US |
dc.identifier.issn | 1069-6563 | en_US |
dc.identifier.issn | 1553-2712 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/73625 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10958123&dopt=citation | en_US |
dc.description.abstract | Objectives: Resuscitation studies of hypertonic saline using controlled and uncontrolled hemorrhage models yield conflicting results with regard to efficacy. These disparate results reflect the use of models and resuscitation regimens that are not comparable between studies. This study evaluated the effects of comparable and clinically relevant resuscitation regimens of 7.5% sodium chloride/6% dextran 70 (HSD) and 0.9% sodium chloride (NS) in a near-fatal uncontrolled hemorrhage model. Methods: Thirty-six swine (14.2 to 21.4 kg) with 4-mm aortic tears were bled to a pulse pressure of 5 mm Hg (40-45 mL/kg). The animals were resuscitated with either NS or HSD administered in volumes that provided equivalent sodium loads at similar rates. Group II (n = 12) was resuscitated with 80 mL/kg of NS at a rate of 4 mL/kg/min. Group III (n = 12) received 9.6 mL/kg of HSD at a rate of 0.48 mL/kg/min. In both groups, crystalloid resuscitation was followed by shed blood infusion (30 mL/kg) at a rate of 2 mL/kg/min. Group I (controls; n = 12) were not resuscitated. Results: One-hour mortality was significantly greater in group I (92%) as compared with group II (33%) and group III (33%) (Fisher's exact test; p = 0.004). Intraperitoneal hemorrhage was significantly greater in group II (34 ± 20 mL/kg) and group III (31 ± 13 mL/kg) as compared with group I (5 ± 2 mL/kg) (ANOVA; p < 0.05). There was no significant difference in hemodynamic parameters between groups II and III. Conclusion: In this model of severe uncontrolled hemorrhage, resuscitation with HSD or NS, administered in volumes that provided equivalent sodium loads at similar rates, had similar effects on mortality, hemodynamic parameters, and hemorrhage from the injury site. | en_US |
dc.format.extent | 95308 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 2000 Society for Academic Emergency Medicine | en_US |
dc.subject.other | Uncontrolled Hemorrhage | en_US |
dc.subject.other | Shock | en_US |
dc.subject.other | Resuscitation | en_US |
dc.subject.other | Hypertonic Saline | en_US |
dc.subject.other | Hemorrhage Models | en_US |
dc.subject.other | Pig | en_US |
dc.title | Resuscitation of Severe Uncontrolled Hemorrhage 7.5% Sodium Chloride/6% Dextran 70 vs 0.9% Sodium Chloride | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Emergency Medicine, University of Michigan Medical Center, Ann Arbor, MI (SAS, SCD, XW) | en_US |
dc.contributor.affiliationother | and Department of Emergency Medicine, Akron City Hospital, Summa Health Systems, Northeastern Ohio College of Medicine, Akron, OH (SJ). | en_US |
dc.identifier.pmid | 10958123 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/73625/1/j.1553-2712.2000.tb02060.x.pdf | |
dc.identifier.doi | 10.1111/j.1553-2712.2000.tb02060.x | en_US |
dc.identifier.source | Academic Emergency Medicine | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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