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UVA II Exposure of Human Skin Results in Decreased Immunization Capacity, Increased Induction of Tolerance and a Unique Pattern of Epidermal Antigen-Presenting Cell Alteration

dc.contributor.authorLeVee, Gordon J.en_US
dc.contributor.authorOberhelman, Loisen_US
dc.contributor.authorAnderson, Tomen_US
dc.contributor.authorKoren, Hillel S.en_US
dc.contributor.authorCooper, Kevin D.en_US
dc.date.accessioned2010-06-01T20:31:46Z
dc.date.available2010-06-01T20:31:46Z
dc.date.issued1997-04en_US
dc.identifier.citationLeVee, Gordon J.; Oberhelman, Lois; Anderson, Tom; Koren, Hillel; Cooper, Kevin D. (1997). "UVA II Exposure of Human Skin Results in Decreased Immunization Capacity, Increased Induction of Tolerance and a Unique Pattern of Epidermal Antigen-Presenting Cell Alteration." Photochemistry and Photobiology 65(4): 622-629. <http://hdl.handle.net/2027.42/73639>en_US
dc.identifier.issn0031-8655en_US
dc.identifier.issn1751-1097en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/73639
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9114737&dopt=citationen_US
dc.description.abstractThe risks incurred from increased exposure to UVA II (320-340 nm) ( i.e. during sunscreen use and extended outdoor exposure, tanning parlors) are not well understood. Therefore, we explored the effects of UVA II on skin immune responses in humans. After a single local exposure (4 minimum erythemal dose [MED]) using a xenon arc lamp filtered with a narrow bandpass filter (335 ± 5 nm full width at half maximum), individuals were contact-sensitized with dinitrochlorobenzene (DNCB) through a UVA II exposure site or through normal skin. UVA II induced a marked decrease in the magnitude of skin immune responses ( P < 0.0001). The UVA II group had only 29% successful sensitizations, as compared to 83% in the control group. The percentage of individuals who remained tolerant to DNCB after two sensitizations was 23.6% for the UVA II-exposed group, as compared to 3.8% in the controls ( P = 0.006). UVA II also uniquely altered the type of antigen-presenting cells present in the epidermis. Human leukocyte antigen (HLA)-DR+ cells in control epidermal cell suspensions (C-EC) comprised a single, homogeneous population of Langerhans cells (LC) with the phenotype: CD1a hi DR mid CD11b − CD36 − (1.5 ± 0.3% of EC). UVA II irradiation reduced the number of such LC to 0.6 ± 0.2% of EC. Although cells expressing the macrophage phenotype: CD1a DR hi CD11b+ CD36+ were increased in UVA II skin, relative to C-EC, these comprised only 10.1 ± 6.1% of the DR+ cells, which is less than that after UVB exposure. Also distinct from UVB, a third population was found in UVA II-EC, which exhibited a novel phenotype: CD1a+ DR+ CD36+ CDllb+; these comprised 11.1 ± 6.9% of the DR+ UVA II-EC. In conclusion, despite the above differences in infiltrating DR cells, both UVB and UVA II reduce the skin's ability to support contact sensitization, induce active suppression (tolerance) and induce a reduction in LC.en_US
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dc.format.extent3109 bytes
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dc.publisherBlackwell Publishing Ltden_US
dc.rights1997 American Society for Photobiologyen_US
dc.titleUVA II Exposure of Human Skin Results in Decreased Immunization Capacity, Increased Induction of Tolerance and a Unique Pattern of Epidermal Antigen-Presenting Cell Alterationen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Dermatology, University of Michigan, Ann Arbor, Ml, USAen_US
dc.contributor.affiliationotherVeterans Affairs Medical Centers, Ann Arbor, Ml and Cleveland, OH, USAen_US
dc.contributor.affiliationotherHealth Effects Research Lab, EPA, Chapel Hill, NC, USAen_US
dc.contributor.affiliationotherCase Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, USAen_US
dc.identifier.pmid9114737en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/73639/1/j.1751-1097.1997.tb01903.x.pdf
dc.identifier.doi10.1111/j.1751-1097.1997.tb01903.xen_US
dc.identifier.sourcePhotochemistry and Photobiologyen_US
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