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The Molecular Adsorbents Recycling System as a Liver Support System Based on Albumin Dialysis: A Summary of Preclinical Investigations, Prospective, Randomized, Controlled Clinical Trial, and Clinical Experience from 19 Centers

dc.contributor.authorStange, Janen_US
dc.contributor.authorHassanein, Tarek i.en_US
dc.contributor.authorMehta, Ravindraen_US
dc.contributor.authorMitzner, Steffen r.en_US
dc.contributor.authorBartlett, Robert H.en_US
dc.date.accessioned2010-06-01T20:46:08Z
dc.date.available2010-06-01T20:46:08Z
dc.date.issued2002-02en_US
dc.identifier.citationStange, Jan; Hassanein, Tarek I . ; Mehta, Ravindra; Mitzner, Steffen R . ; Bartlett, Robert H . (2002). "The Molecular Adsorbents Recycling System as a Liver Support System Based on Albumin Dialysis: A Summary of Preclinical Investigations, Prospective, Randomized, Controlled Clinical Trial, and Clinical Experience from 19 Centers." Artificial Organs 26(2): 103-110. <http://hdl.handle.net/2027.42/73869>en_US
dc.identifier.issn0160-564Xen_US
dc.identifier.issn1525-1594en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/73869
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11879237&dopt=citationen_US
dc.description.abstractArtificial liver support aims to prolong survival time of patients with liver failure by detoxification. Albumin as a molecular adsorbent in dialysis solution is capable of attracting even tightly albumin-bound toxins from blood into the dialysate if a specific dialysis membrane is used and if the albumin's binding sites are on-line-purified by a sorbent/dialysis-based recycling system (i.e., molecular adsorbents recycling system, or MARS). The MARS technology has been shown to remove water-soluble and albumin-bound toxins and to provide renal support in case of renal failure. Fourteen centers have reported that MARS treatment improved mental status of patients with liver failure and hepatic encephalopathy. In treating liver failure and cholestasis, MARS was associated with hemodynamic stabilization, improvement of hepatic and kidney function, and disappearance of pruritus. In hepatic failure and hepatorenal syndrome, a prospective, randomized, controlled trial of MARS treatment was able to prolong survival time significantly. MARS has been used in 26 patients with acute liver failure or primary graft dysfunction. Nineteen centers reporting on 103 patients have shown that MARS treatment is safe, easy to handle, feasible, and effective.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing, Inc.en_US
dc.rights2002 International Society for Artificial Organsen_US
dc.subject.otherAlbumin Dialysisen_US
dc.subject.otherClinical Trialsen_US
dc.subject.otherLiver Failureen_US
dc.subject.otherLiver Supporten_US
dc.subject.otherMolecular Adsorbents Recycling Systemen_US
dc.subject.otherMulticenter Trialsen_US
dc.titleThe Molecular Adsorbents Recycling System as a Liver Support System Based on Albumin Dialysis: A Summary of Preclinical Investigations, Prospective, Randomized, Controlled Clinical Trial, and Clinical Experience from 19 Centersen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum§ Department of Surgery, University of Michigan Hospitals, Ann Arbor, Michigan, U.S.A.en_US
dc.contributor.affiliationother* Division of Gastroenterology, Hepatology;en_US
dc.contributor.affiliationother† Division of Nephrology, UCSD Medical Center, San Diego, California, U.S.A.;en_US
dc.contributor.affiliationother† Division of Nephrology, Department of Internal Medicine, University of Rostock, Rostock, Germany; anden_US
dc.identifier.pmid11879237en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/73869/1/j.1525-1594.2002.06822.x.pdf
dc.identifier.doi10.1046/j.1525-1594.2002.06822.xen_US
dc.identifier.sourceArtificial Organsen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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