View Item 

Show simple item record

Molecular Mechanisms of Photoaging in Human Skin In Vivo and Their Prevention by All-Trans Retinoic Acid

dc.contributor.authorFisher, Gary J.en_US
dc.contributor.authorTalwar, Harvinder S.en_US
dc.contributor.authorLin, Jiayuhen_US
dc.contributor.authorVoorhees, John J.en_US
dc.date.accessioned2010-06-01T20:52:50Z
dc.date.available2010-06-01T20:52:50Z
dc.date.issued1999-02en_US
dc.identifier.citationFisher, Gary J.; Talwar, Harvinder S.; Lin, Jiayuh; Voorhees, John J. (1999). "Molecular Mechanisms of Photoaging in Human Skin In Vivo and Their Prevention by All-Trans Retinoic Acid." Photochemistry and Photobiology 69(2): 154-157. <http://hdl.handle.net/2027.42/73977>en_US
dc.identifier.issn0031-8655en_US
dc.identifier.issn1751-1097en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/73977
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10048311&dopt=citationen_US
dc.description.abstractSolar UV radiation damages human skin, affecting skin tone and resiliency and leading to premature aging (photoaging), the symptoms of which include leathery texture, wrinkles, mottled pigmentation, laxity and sallowness. We propose that photoaging results largely from UV induction of matrix metalloproteinases (MMP) that degrade skin collagen. We find that pretreatment of human skin with all- trans retinoic acid (tRA) inhibits UV induction of MMP, suggesting that tRA can protect against UV-induced collagen destruction and may therefore be able to lessen the effects of photoaging. The tRA prevents UV-induced accumulation of c-Jun protein, which is required for MMP gene expression. Activation of c-Jun transcriptional activity requires N-terminal phosphorylation. The majority of c-Jun in human skin in vivo is Nterminal phosphorylated. Topically applied t RA does not inhibit N-terminal phosphorylation by UV-induced c-Jun kinase activity in human skin. The tRA likely acts to reduce UV induction of c-Jun protein by stimulating its breakdown through the ubiquitin-proteasome pathway.en_US
dc.format.extent490849 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1999 American Society for Photobiologyen_US
dc.titleMolecular Mechanisms of Photoaging in Human Skin In Vivo and Their Prevention by All-Trans Retinoic Aciden_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Dermatology, University of Michigan, Ann Arbor, Ml, USAen_US
dc.identifier.pmid10048311en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/73977/1/j.1751-1097.1999.tb03268.x.pdf
dc.identifier.doi10.1111/j.1751-1097.1999.tb03268.xen_US
dc.identifier.sourcePhotochemistry and Photobiologyen_US
dc.identifier.citedreferenceGilchrest, B. A. and M. Yaar ( 1992 ) Aging and photoaging of the skin: observations at the cellular and molecular level. Br. J. Dermatol. 127, 25 – 35.en_US
dc.identifier.citedreferenceEllis, C. N., J. S. Weiss, T. A. Hamilton, J. T. Headmgton, A. S. Zelickson and J. J. Voorhees ( 1990 ) Sustained improvement with prolonged topical tretinoin (retinoic acid) for photoaged skin. J. Am. Acad. Dermatol. 23, 629 – 637.en_US
dc.identifier.citedreferenceFisher, G. J., Z. Q. Wang, S. C. Datta, J. Varani, S. Kang and J. J. Voorhees ( 1997 ) Pathophysiology of premature skin aging induced by ultraviolet light. N. Engl. J. Med. 337, 1419 – 1428.en_US
dc.identifier.citedreferenceFisher, G. J., S. C. Datta, H. S. Talwar, Z. Q. Wang, J. Varani, S. Kang and J. J. Voorhees ( 1996 ) Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature 379, 335 – 379.en_US
dc.identifier.citedreferenceFisher, G. J., J. Esmann, C. E. Griffiths, H. S. Talwar, E. A. Duell, C. Hammerberg, J. T. Elder, L. J. Finkel, G. D. Karabin and B. J. Nickoloff ( 1991 ) Cellular, immunologic and biochemical characterization of topical retinoic acid-treated human skin. J. Invest. Dermatol. 96, 699 – 707.en_US
dc.identifier.citedreferenceHibi, M., A. Lin, T. Smeal, A. Minden and M. Karin ( 1993 ) Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes & Dev. 7, 2135 – 2148.en_US
dc.identifier.citedreferenceFisher, G. J., H. S. Talwar, J. H. Xiao, S. C. Datta, A. P. Reddy, M. P. Gaub, C. Rochette-Egly, P. Chambon and J. J. Voorhees ( 1994 ) Immunological identification and functional quantization of retinoic acid and retinoid X receptor proteins in human skin. J. Biol. Chem. 269, 20629 – 20635.en_US
dc.identifier.citedreferenceDignam, J. D., R. M. Lebovitz and R. G. Roeder ( 1983 ) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475 – 1489.en_US
dc.identifier.citedreferenceRosette, C. and M. Karin ( 1996 ) Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274, 1194 – 1197.en_US
dc.identifier.citedreferenceFisher, G. J., H. S. Talwar, J. Lin, P. Lin, F. McPhillips, Z. Q. Wang, X. Li, Y. Wan, S. Kang and I. J. Voorhees ( 1998 ) Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo. J. Clin. Invest. 101, 1432 – 1440.en_US
dc.identifier.citedreferenceAngel, P. and M. Karin ( 1992 ) Specific members of the Jun protein family regulate collagenase expression in response to various extracellular stimuli. Matrix Suppl. 1, 156 – 164.en_US
dc.identifier.citedreferenceBorden, P. and R. A. Heller ( 1997 ) Transcriptional control of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases. Crit. Rev. Eukaryotic Gene Expression 7, 159 – 178.en_US
dc.identifier.citedreferenceChen, J. Y., S. Penco, J. Ostrowski, P. Balaguer, M. Pons, J. E. Starrett, P. Reczek, P. Chambon and H. Gronemeyer ( 1995 ) RAR-specific agonists/antagonists which dissociate transactivation and AP-1 transrepression, inhibit anchorage-independent cell proliferation. EMBO J. 14, 1187 – 1197.en_US
dc.identifier.citedreferenceMusti, A. M., M. Treier and D. Bohmann ( 1997 ) Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases. Science 275, 400 – 402.en_US
dc.identifier.citedreferenceLee, H. Y., G. L. Walsh, M. I. Dawson, W. K. Hong and J. M. Kurie ( 1998 ) All-trans retinoic acid inhibits Jun N-terminal kinase-dependent signaling pathways. J. Biol. Chem. 273, 7066 – 7071.en_US
dc.identifier.citedreferenceCaelles, C., J. M. Gonzalez-Sancho and A. Munoz ( 1997 ) Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes & Dev. 11, 3351 – 3364.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
j.1751-1097.1999.tb03268.x.pdf
Size:
479.3KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.