The Effective Oncotic Pressure of Dextran 1
dc.contributor.author | Mulcahy, John J. | en_US |
dc.contributor.author | Malvin, Richard L. | en_US |
dc.date.accessioned | 2010-06-01T21:06:18Z | |
dc.date.available | 2010-06-01T21:06:18Z | |
dc.date.issued | 1975-10 | en_US |
dc.identifier.citation | Mulcahy, John J.; Malvin, Richard L. (1975). "The Effective Oncotic Pressure of Dextran 1 ." Vox Sanguinis 29(4): 237-241. <http://hdl.handle.net/2027.42/74193> | en_US |
dc.identifier.issn | 0042-9007 | en_US |
dc.identifier.issn | 1423-0410 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/74193 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1096471&dopt=citation | en_US |
dc.description.abstract | Measurement of plasma volume before and after the acute infusion of commercial dextran revealed that all brands tested were hyperoncotic by a factor of approximately 2. By mixing 6% dextran with 0.9% saline in 1:1 proportion a 3% dextran solution was obtained which was nearly isoncotic in our dogs. The most likely explanation for the discrepancy is that the 6% solution contains a high proportion of molecules of lower molecular weight resulting in a greater oncotic pressure than predicted on the basis of the average molecular weight. In addition, this leads to a rapid loss of this solute from the blood. Clinicians and researchers should be aware of the possibility that the dextran preparation they are using is not truly isoncotic. | en_US |
dc.format.extent | 199823 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1975 Blackwell Publishing Ltd | en_US |
dc.title | The Effective Oncotic Pressure of Dextran 1 | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Urology, Department of Surgery, University of Kentucky, Lexington, Ky., and Department of Physiology, University of Michigan, Ann Arbor, Mich | en_US |
dc.identifier.pmid | 1096471 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/74193/1/j.1423-0410.1975.tb00503.x.pdf | |
dc.identifier.doi | 10.1111/j.1423-0410.1975.tb00503.x | en_US |
dc.identifier.source | Vox Sanguinis | en_US |
dc.identifier.citedreference | Nitschmann, H.; Gygax, H. R.; Moser, P., and Stoll, H. R.: A simple concentration osmometer and its application to the determination of the osmotic efficiency of plasma substitutes. Vox Sang. 12: 106 – 117 ( 1967 ). | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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