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Molecular Genetic Analysis of the ABO Blood Group System: 1. Weak Subgroups: A 3 and B 3 Alleles

dc.contributor.authorYamamoto, Fumi-ichiroen_US
dc.contributor.authorMcNeil, Patricia D.en_US
dc.contributor.authorYamamoto, Miyakoen_US
dc.contributor.authorHakomori, Sen-itirohen_US
dc.contributor.authorHarris, Teresaen_US
dc.contributor.authorJudd, W. Johnen_US
dc.contributor.authorDavenport, Robertson D.en_US
dc.date.accessioned2010-06-01T21:37:37Z
dc.date.available2010-06-01T21:37:37Z
dc.date.issued1993-02en_US
dc.identifier.citationYamamoto, Fumi-ichiro; McNeil, Patricia D.; Yamamoto, Miyako; Hakomori, Sen-itiroh; Harris, Teresa; Judd, W. John; Davenport, Robertson D. (1993). "Molecular Genetic Analysis of the ABO Blood Group System: 1. Weak Subgroups: A 3 and B 3 Alleles." Vox Sanguinis 64(2): 116-119. <http://hdl.handle.net/2027.42/74676>en_US
dc.identifier.issn0042-9007en_US
dc.identifier.issn1423-0410en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/74676
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8456555&dopt=citationen_US
dc.description.abstractWe have determined the nucleotide sequences of the coding region in the last two coding exom of ABO genes (which occupy 91% of the soluble form of A 1 transferase) from 7 individuals with weak subgroup phenotypes. Four of the individuals had an A 3 phenotype and 3 individuals had a B 3 phenotype. We determined the nucleotide sequences based on PCR followed by subcloning and DNA sequencing of the amplified fragments. Two cases of the A 3 allele and 1 case of the B 3 allele were found to contain a single-base substitution which resulted in an amino acid substitution. However, no other cases of A 3 and B 3 alleles were found to contain differences in this region. This finding demonstrates for the first time heterogeneity among these weak subgroups at the nucleotide level.en_US
dc.format.extent445463 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rights1993 Blackwell Publishing Ltden_US
dc.titleMolecular Genetic Analysis of the ABO Blood Group System: 1. Weak Subgroups: A 3 and B 3 Allelesen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelOncology and Hematologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Immunohematology, The University of Michigan Hospitals, Ann Arbor, Mich, USAen_US
dc.contributor.affiliationumDepartments of Pathology, The University of Michigan Hospitals, Ann Arbor, Mich, USAen_US
dc.contributor.affiliationotherThe Biomembrane Institute and University of Washington, Seattle, Wash., USAen_US
dc.contributor.affiliationotherPacific Northwest Regional Blood Services, Portland, Oreg., USAen_US
dc.identifier.pmid8456555en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/74676/1/j.1423-0410.1993.tb02528.x.pdf
dc.identifier.doi10.1111/j.1423-0410.1993.tb02528.xen_US
dc.identifier.sourceVox Sanguinisen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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