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The Embedding of Meta-tetra(Hydroxyphenyl)-Chlorin into Silica Nanoparticle Platforms for Photodynamic Therapy and Their Singlet Oxygen Production and pH-dependent Optical Properties ¶

dc.contributor.authorYan, Feien_US
dc.contributor.authorKopelman, Raoulen_US
dc.date.accessioned2010-06-01T21:57:27Z
dc.date.available2010-06-01T21:57:27Z
dc.date.issued2003-12en_US
dc.identifier.citationYan, Fei; Kopelman, Raoul (2003). "The Embedding of Meta-tetra(Hydroxyphenyl)-Chlorin into Silica Nanoparticle Platforms for Photodynamic Therapy and Their Singlet Oxygen Production and pH-dependent Optical Properties ¶ ." Photochemistry and Photobiology 78(6): 587-591. <http://hdl.handle.net/2027.42/74989>en_US
dc.identifier.issn0031-8655en_US
dc.identifier.issn1751-1097en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/74989
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14743867&dopt=citationen_US
dc.description.abstractThis study relates to nanoparticle (NP) platforms that attach to tumor cells externally and only deliver singlet oxygen for photodynamic therapy (PDT) while conserving the embedded photosensitizers (PS). As a model, we demonstrate the successful embedding of the PS meta-tetra(hydroxyphenyl)-chlorin ( m -THPC) in NP that are based on a sol–gel silica matrix and also show its positive effect on the singlet oxygen production. The embedding of m -THPC inside silica NP is accomplished by a modified StÖber sol–gel process, in which (3-aminopropyl)-triethoxysilane is introduced during the reaction. Singlet oxygen delivery by the targetable photodynamic NP exceeds that from free PS molecules. In the physiological pH range, there is no significant pH-induced decrease in the fluorescence of m -THPC embedded in silica NP, which might otherwise affect the efficiency of PDT.en_US
dc.format.extent121832 bytes
dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rights2003 American Society for Photobiologyen_US
dc.titleThe Embedding of Meta-tetra(Hydroxyphenyl)-Chlorin into Silica Nanoparticle Platforms for Photodynamic Therapy and Their Singlet Oxygen Production and pH-dependent Optical Properties ¶en_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Chemistry, University of Michigan, Ann Arbor, MIen_US
dc.identifier.pmid14743867en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/74989/1/0031-8655_2003_0780587TEOMIS2.0.CO2.pdf
dc.identifier.doi10.1562/0031-8655(2003)0780587TEOMIS2.0.CO2en_US
dc.identifier.sourcePhotochemistry and Photobiologyen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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