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Keratins as markers of differentiated taste cells of the rat

dc.contributor.authorKnapp, Lauren T.en_US
dc.contributor.authorLawton, Anneen_US
dc.contributor.authorOakley, Bruceen_US
dc.contributor.authorWong, Liannaen_US
dc.contributor.authorZhang, Chunxiaoen_US
dc.date.accessioned2010-06-01T22:19:26Z
dc.date.available2010-06-01T22:19:26Z
dc.date.issued1995-06en_US
dc.identifier.citationKnapp, Lauren; Lawton, Anne; Oakley, Bruce; Wong, Lianna; Zhang, Chunxiao (1995). "Keratins as markers of differentiated taste cells of the rat." Differentiation 58(5): 341-349. <http://hdl.handle.net/2027.42/75334>en_US
dc.identifier.issn0301-4681en_US
dc.identifier.issn1432-0436en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/75334
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7542613&dopt=citationen_US
dc.description.abstractCytokeratins in taste buds were immunocytochemically evaluated with monoclonal antibodies. In each of six different epithelial sites in the rat oral cavity, intragemmal cells of taste buds were immunoreactive for keratin polypeptides 8, 18, and 19, as well as for keratin 7, which has not been previously reported in taste buds. Keratin-18-like immunoreactivity was present in fewer than half of the intragemmal cells, whereas all intragemmal cells were immunopositive for keratins 7, 8, and 19. Apart from some salivary duct cells, no other cells in the tongue were immunoreactive for any of these four keratins. Morphological and immunocytochemical profiles indicate that taste buds are islets of simple epithelium embedded in an expanse of stratified squamous epithelium. These simple epithelial cells and their keratins are nerve-dependent, since denervation eliminated all four keratins and replaced elongated taste cells of the vallate papilla with stratified squamous epithelium. We conclude that antibodies against keratins 7, 8, or 19 are useful markers for intragemmal cells in studies of taste bud development, degeneration, regeneration, turnover and tissue culture.en_US
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dc.format.extent3109 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherBlackwell Publishing Ltden_US
dc.rightsSpringer-Verlag Berlin Heidelberg 1995en_US
dc.titleKeratins as markers of differentiated taste cells of the raten_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelOncology and Hematologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biology, 3127 Natural Science Building, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.identifier.pmid7542613en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/75334/1/j.1432-0436.1995.5850341.x.pdf
dc.identifier.doi10.1046/j.1432-0436.1995.5850341.xen_US
dc.identifier.sourceDifferentiationen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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