Stimulation of Adenosine A 3 Receptors in Cerebral Ischemia: Neuronal Death, Recovery, or Both?
dc.contributor.author | Lubitz, Dag K. J. E. | en_US |
dc.contributor.author | Ye, Wen | en_US |
dc.contributor.author | McClellan, Jennifer | en_US |
dc.contributor.author | Lin, Rick C. S. | en_US |
dc.date.accessioned | 2010-06-01T22:23:52Z | |
dc.date.available | 2010-06-01T22:23:52Z | |
dc.date.issued | 1999-12 | en_US |
dc.identifier.citation | LUBITZ, DAG K.J.E.; YE, WEN; McCLELLAN, JENNIFER; LIN, RICK C.-S. (1999). "Stimulation of Adenosine A 3 Receptors in Cerebral Ischemia: Neuronal Death, Recovery, or Both?." Annals of the New York Academy of Sciences 890(1 NEUROPROTECTIVE AGENTS: FOURTH INTERNATIONAL CONFERENCE ): 93-106. <http://hdl.handle.net/2027.42/75391> | en_US |
dc.identifier.issn | 0077-8923 | en_US |
dc.identifier.issn | 1749-6632 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/75391 | |
dc.description.abstract | The role of the adenosine A 3 receptor continues to baffle, and, despite an increasing number of studies, the currently available data add to, rather than alleviate, the existing confusion. The reported effects of adenosine A 3 receptor stimulation appear to depend on the pattern of drug administration (acute vs. chronic), dose, and type of the target tissue. Thus, while acute exposure to A 3 receptor agonists protects against myocardial ischemia, it is severely damaging when these agents are given shortly prior to cerebral ischemia. Mast cells degranulate when their A 3 receptors are stimulated. Degranulation of neutrophils is, on the other hand, impaired. While reduced production of reactive nitrogen species has been reported following activation of A 3 receptors in collagen-induced arthritis, the process appears to be enhanced in cerebral ischemia. Indeed, immunocytochemical studies indicate that both pre- and postischemic treatment with A 3 receptor antagonist dramatically reduces nitric oxide synthase in the affected hippocampus. Even more surprisingly, low doses of A 3 receptor agonists seem to enhance astrocyte proliferation, while high doses induce their apoptosis. This review concentrates on the studies of cerebral A 3 receptors and, based on the available evidence, discusses the possibility of adenosine A 3 receptor serving as an integral element of the endogenous cerebral neuroprotective complex consisting of adenosine and its receptors. | en_US |
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dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
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dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | New York Academy of Sciences 1999 | en_US |
dc.title | Stimulation of Adenosine A 3 Receptors in Cerebral Ischemia: Neuronal Death, Recovery, or Both? | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Science (General) | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Emergency Medicine Research Laboratories, Department of Emergency Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109-0303, USA | en_US |
dc.contributor.affiliationother | Department of Anatomy, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, USA | en_US |
dc.identifier.pmid | 10668416 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/75391/1/j.1749-6632.1999.tb07984.x.pdf | |
dc.identifier.doi | 10.1111/j.1749-6632.1999.tb07984.x | en_US |
dc.identifier.source | Annals of the New York Academy of Sciences | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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