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Biological systems of the host cell involved in Agrobacterium infection

dc.contributor.authorCitovsky, Vitalyen_US
dc.contributor.authorKozlovsky, Stanislav V.en_US
dc.contributor.authorLacroix, Benoîten_US
dc.contributor.authorZaltsman, Adien_US
dc.contributor.authorDafny-Yelin, Meryen_US
dc.contributor.authorVyas, Shachien_US
dc.contributor.authorTovkach, Andriyen_US
dc.contributor.authorTzfira, Tzvien_US
dc.date.accessioned2010-06-01T22:26:02Z
dc.date.available2010-06-01T22:26:02Z
dc.date.issued2007-01en_US
dc.identifier.citationCitovsky, Vitaly; Kozlovsky, Stanislav V.; Lacroix, BenoÎt; Zaltsman, Adi; Dafny-Yelin, Mery; Vyas, Shachi; Tovkach, Andriy; Tzfira, Tzvi (2007). "Biological systems of the host cell involved in Agrobacterium infection." Cellular Microbiology 9(1): 9-20. <http://hdl.handle.net/2027.42/75425>en_US
dc.identifier.issn1462-5814en_US
dc.identifier.issn1462-5822en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/75425
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17222189&dopt=citationen_US
dc.description.abstractGenetic transformation of plants by Agrobacterium , which in nature causes neoplastic growths, represents the only known case of trans -kingdom DNA transfer. Furthermore, under laboratory conditions, Agrobacterium can also transform a wide range of other eukaryotic species, from fungi to sea urchins to human cells. How can the Agrobacterium virulence machinery function in such a variety of evolutionarily distant and diverse species? The answer to this question lies in the ability of Agrobacterium to hijack fundamental cellular processes which are shared by most eukaryotic organisms. Our knowledge of these host cellular functions is critical for understanding the molecular mechanisms that underlie genetic transformation of eukaryotic cells. This review outlines the bacterial virulence machinery and provides a detailed discussion of seven major biological systems of the host cell–cell surface receptor arrays, cellular motors, nuclear import, chromatin targeting, targeted proteolysis, DNA repair, and plant immunity – thought to participate in the Agrobacterium -mediated genetic transformation.en_US
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dc.publisherBlackwell Publishing Ltden_US
dc.rights© 2006 The Authors; Journal compilation © 2006 Blackwell Publishing Ltden_US
dc.titleBiological systems of the host cell involved in Agrobacterium infectionen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.en_US
dc.contributor.affiliationotherDepartment of Biochemistry and Cell Biology, State University of New York, Stony Brook, NY 11794, USA.en_US
dc.identifier.pmid17222189en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/75425/1/j.1462-5822.2006.00830.x.pdf
dc.identifier.doi10.1111/j.1462-5822.2006.00830.xen_US
dc.identifier.sourceCellular Microbiologyen_US
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