Systemic MMP inhibition for periodontal wound repair: results of a multi-centre randomized-controlled clinical trial
dc.contributor.author | Gapski, Ricardo | en_US |
dc.contributor.author | Hasturk, Hatice | en_US |
dc.contributor.author | Van Dyke, Thomas E. | en_US |
dc.contributor.author | Oringer, Richard J. | en_US |
dc.contributor.author | Wang, Shufang | en_US |
dc.contributor.author | Braun, Thomas M. | en_US |
dc.contributor.author | Giannobile, William V. | en_US |
dc.date.accessioned | 2010-06-01T22:28:55Z | |
dc.date.available | 2010-06-01T22:28:55Z | |
dc.date.issued | 2009-02 | en_US |
dc.identifier.citation | Gapski, Ricardo; Hasturk, Hatice; Van Dyke, Thomas E.; Oringer, Richard J.; Wang, Shufang; Braun, Thomas M.; Giannobile, William V. (2009). "Systemic MMP inhibition for periodontal wound repair: results of a multi-centre randomized-controlled clinical trial." Journal of Clinical Periodontology 36(2): 149-156. <http://hdl.handle.net/2027.42/75470> | en_US |
dc.identifier.issn | 0303-6979 | en_US |
dc.identifier.issn | 1600-051X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/75470 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19207891&dopt=citation | en_US |
dc.description.abstract | Aim : This multi-centre, prospective, controlled trial was designed to examine the biological response of the matrix metalloproteinase(MMP) inhibitor subantimicrobial dose doxycycline (SDD) combined with access flap surgery on periodontal wound repair in patients with chronic severe periodontitis. Material and Methods : Seventy subjects were enrolled into a 12-month, randomized, placebo-controlled, double-masked trial to evaluate disease response to 6 months therapy and “wash-out” of either placebo+surgery or SDD (20 mg b.i.d.)+surgery. Primary outcome measure included clinical attachment levels (CAL) and secondary outcomes included probing depth (PD), bleeding on probing (BOP), as well as gingival crevicular fluid bone marker assessment [collagen telopeptides (ICTP)]. These measurements were taken at baseline through 12 months post-surgery and drug administration. Results : Patients treated with SDD and surgery demonstrated stronger reductions in PD in surgically-treated sites of ges;7 mm as well as gains in CAL ( p <0.004). Furthermore, SDD+surgery resulted in short-term reductions in ICTP levels compared with placebo. Rebounds in ICTP levels and clinical parameters occurred when SDD was withdrawn. Conclusions : The results from this multi-centre study suggests that SDD in combination with surgery improves the short-term response of periodontal therapy by reducing PD, increasing CAL gain and inhibiting early stage bone resorption. | en_US |
dc.format.extent | 386246 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | © 2009 John Wiley & Sons A/S | en_US |
dc.subject.other | Doxycycline | en_US |
dc.subject.other | Matrix Metalloproteinases | en_US |
dc.subject.other | MMP | en_US |
dc.subject.other | Periodontal | en_US |
dc.subject.other | Wound Healing | en_US |
dc.title | Systemic MMP inhibition for periodontal wound repair: results of a multi-centre randomized-controlled clinical trial | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Michigan Center for Oral Health Research and Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA ; | en_US |
dc.contributor.affiliationum | Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Periodontology and Oral Biology, Boston University, Boston, MA, USA ; | en_US |
dc.contributor.affiliationother | Department of Periodontics, Stony Brook University, Stony Brook, NY, USA ; | en_US |
dc.identifier.pmid | 19207891 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/75470/1/j.1600-051X.2008.01351.x.pdf | |
dc.identifier.doi | 10.1111/j.1600-051X.2008.01351.x | en_US |
dc.identifier.source | Journal of Clinical Periodontology | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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