Polymerizing the fibre between bacteria and host cells: the biogenesis of functional amyloid fibres
dc.contributor.author | Epstein, Elisabeth Ashman | en_US |
dc.contributor.author | Chapman, Matthew R. | en_US |
dc.date.accessioned | 2010-06-01T22:34:08Z | |
dc.date.available | 2010-06-01T22:34:08Z | |
dc.date.issued | 2008-07 | en_US |
dc.identifier.citation | Epstein, Elisabeth Ashman; Chapman, Matthew R. (2008). "Polymerizing the fibre between bacteria and host cells: the biogenesis of functional amyloid fibres." Cellular Microbiology 10(7): 1413-1420. <http://hdl.handle.net/2027.42/75549> | en_US |
dc.identifier.issn | 1462-5814 | en_US |
dc.identifier.issn | 1462-5822 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/75549 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18373633&dopt=citation | en_US |
dc.description.abstract | Amyloid fibres are proteinaceous aggregates associated with several human diseases, including Alzheimer's, Huntington's and Creutzfeldt Jakob's. Disease-associated amyloid formation is the result of proteins that misfold and aggregate into β sheet-rich fibre polymers. Cellular toxicity is readily associated with amyloidogenesis, although the molecular mechanism of toxicity remains unknown. Recently, a new class of ‘functional’ amyloid fibres was discovered that demonstrates that amyloids can be utilized as a productive part of cellular biology. These functional amyloids will provide unique insights into how amyloid formation can be controlled and made less cytotoxic. Bacteria produce some of the best-characterized functional amyloids, including a surface amyloid fibre called curli. Assembled by enteric bacteria, curli fibres mediate attachment to surfaces and host tissues. Some bacterial amyloids, like harpins and microcinE492, have exploited amyloid toxicity in a directed and functional manner. Here, we review and discuss the functional amyloids assembled by bacteria. Special emphasis will be paid to the biology of functional amyloid synthesis and the connections between bacterial physiology and pathology. | en_US |
dc.format.extent | 284679 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | © 2008 Blackwell Publishing Ltd | en_US |
dc.title | Polymerizing the fibre between bacteria and host cells: the biogenesis of functional amyloid fibres | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 18373633 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/75549/1/j.1462-5822.2008.01148.x.pdf | |
dc.identifier.doi | 10.1111/j.1462-5822.2008.01148.x | en_US |
dc.identifier.source | Cellular Microbiology | en_US |
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