Value of delayed hypointensity and delayed enhancing rim in magnetic resonance imaging diagnosis of small hepatocellular carcinoma in the cirrhotic liver
dc.contributor.author | Khan, Asra S. | en_US |
dc.contributor.author | Hussain, Hero K. | en_US |
dc.contributor.author | Johnson, Timothy D. | en_US |
dc.contributor.author | Weadock, William J. | en_US |
dc.contributor.author | Pelletier, Shawn J. | en_US |
dc.contributor.author | Marrero, Jorge A. | en_US |
dc.date.accessioned | 2010-08-02T17:46:53Z | |
dc.date.available | 2011-03-01T16:26:47Z | en_US |
dc.date.issued | 2010-08 | en_US |
dc.identifier.citation | Khan, Asra S.; Hussain, Hero K.; Johnson, Timothy D.; Weadock, William J.; Pelletier, Shawn J.; Marrero, Jorge A. (2010). "Value of delayed hypointensity and delayed enhancing rim in magnetic resonance imaging diagnosis of small hepatocellular carcinoma in the cirrhotic liver." Journal of Magnetic Resonance Imaging 32(2): 360-366. <http://hdl.handle.net/2027.42/77511> | en_US |
dc.identifier.issn | 1053-1807 | en_US |
dc.identifier.issn | 1522-2586 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/77511 | |
dc.description.abstract | Purpose: To determine the diagnostic utility of delayed hypointensity and delayed enhancing rim on magnetic resonance imaging (MRI) as indicators of hepatocellular carcinoma (HCC) in arterially enhancing nodules ≤5 cm in the cirrhotic liver and determine the features that best predict HCC. Materials and Methods: Gadolinium-enhanced MRI studies performed from January 2001 to December 2004 in patients with cirrhosis were evaluated for arterially enhancing nodules measuring ≤5 cm. Verification was via explant correlation, biopsy, or imaging follow-up. Sensitivity and specificity of diagnostic features of HCC were calculated. Features predictive of HCC were determined using the Generalized Estimating Equation approach. Results: In all, 116 arterially enhancing nodules were identified in 80 patients (<2 cm: n = 79, 2–5 cm n = 37). Sensitivity and specificity of delayed hypointensity for HCC measuring ≤5 cm, 2–5 cm, and <2 cm were 0.54 (40 of 74) and 0.86 (36 of 42); 0.72 (23 of 32) and 0.80 (4 of 5); and 0.41 (17 of 42) and 0.87 (32 of 37). For the delayed enhancing rim sensitivity and specificity were 0.64 (47 of 74) and 0.86 (36 of 42); 0.75 (24 of 32) and 1.0 (5 of 5); and 0.55 (23 of 42) and 0.83 (31 of 37), respectively. Lesion size (≥2 cm) and delayed enhancing rim, as main features and their interaction, were the most significant predictors of HCC. Conclusion: Delayed hypointensity and enhancing rim improve the specificity of diagnosis of HCC of all sizes but are seen less frequently in small (<2 cm) HCC. Nodule size (≥2 cm) and delayed enhancing rim are the strongest predictors of HCC. J. Magn. Reson. Imaging 2010;32:360–366. © 2010 Wiley-Liss, Inc. | en_US |
dc.format.extent | 258851 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Imaging | en_US |
dc.title | Value of delayed hypointensity and delayed enhancing rim in magnetic resonance imaging diagnosis of small hepatocellular carcinoma in the cirrhotic liver | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA ; Dept. of Radiology, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor MI 48109 | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.identifier.pmid | 20677263 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/77511/1/22271_ftp.pdf | |
dc.identifier.doi | 10.1002/jmri.22271 | en_US |
dc.identifier.source | Journal of Magnetic Resonance Imaging | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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