Ultrasound ionization of biomolecules

Wu, Chen-I; Wang, Yi-Sheng; Chen, Nelson G.; Wu, Chung-Yi; Chen, Chung-Hsuan

2010-09-15

Citation: Wu, Chen-I; Wang, Yi-Sheng; Chen, Nelson G.; Wu, Chung-Yi; Chen, Chung-Hsuan (2010). "Ultrasound ionization of biomolecules." Rapid Communications in Mass Spectrometry 24(17): 2569-2574. <http://hdl.handle.net/2027.42/77951>

Abstract: To date, mass spectrometric analysis of biomolecules has been primarily performed with either matrix-assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI). In this work, ultrasound produced by a simple piezoelectric device is shown as an alternative method for soft ionization of biomolecules. Precursor ions of proteins, saccharides and fatty acids showed little fragmentation. Cavitation is considered as a primary mechanism for the ionization of biomolecules. Copyright © 2010 John Wiley & Sons, Ltd.

ISSN: 0951-4198, 1097-0231

DOIs: 10.1002/rcm.4677

Handle: http://hdl.handle.net/2027.42/77951

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