Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity
dc.contributor.author | Napadow, Vitaly | en_US |
dc.contributor.author | LaCount, Lauren | en_US |
dc.contributor.author | Park, Kyungmo | en_US |
dc.contributor.author | As-Sanie, Sawsan | en_US |
dc.contributor.author | Clauw, Daniel J. | en_US |
dc.contributor.author | Harris, Richard E. | en_US |
dc.date.accessioned | 2010-09-02T15:24:15Z | |
dc.date.available | 2011-03-01T16:26:47Z | en_US |
dc.date.issued | 2010-08 | en_US |
dc.identifier.citation | Napadow, Vitaly; LaCount, Lauren; Park, Kyungmo; As-Sanie, Sawsan; Clauw, Daniel J.; Harris, Richard E. (2010). "Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity." Arthritis & Rheumatism 62(8): 2545-2555. <http://hdl.handle.net/2027.42/77979> | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.issn | 1529-0131 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/77979 | |
dc.description.abstract | Objective Fibromyalgia (FM) is considered to be the prototypical central chronic pain syndrome and is associated with widespread pain that fluctuates spontaneously. Multiple studies have demonstrated altered brain activity in these patients. The objective of this study was to investigate the degree of connectivity between multiple brain networks in patients with FM, as well as how activity in these networks correlates with the level of spontaneous pain. Methods Resting-state functional magnetic resonance imaging (FMRI) data from 18 patients with FM and 18 age-matched healthy control subjects were analyzed using dual-regression independent components analysis, which is a data-driven approach for the identification of independent brain networks. Intrinsic, or resting-state, connectivity was evaluated in multiple brain networks: the default mode network (DMN), the executive attention network (EAN), and the medial visual network (MVN), with the MVN serving as a negative control. Spontaneous pain levels were also analyzed for covariance with intrinsic connectivity. Results Patients with FM had greater connectivity within the DMN and right EAN (corrected P [ P corr ] < 0.05 versus controls), and greater connectivity between the DMN and the insular cortex, which is a brain region known to process evoked pain. Furthermore, greater intensity of spontaneous pain at the time of the FMRI scan correlated with greater intrinsic connectivity between the insula and both the DMN and right EAN ( P corr < 0.05). Conclusion These findings indicate that resting brain activity within multiple networks is associated with spontaneous clinical pain in patients with FM. These findings may also have broader implications for how subjective experiences such as pain arise from a complex interplay among multiple brain networks. | en_US |
dc.format.extent | 382973 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.title | Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor ; Dr. Clauw has received consulting fees, speaking fees, and/or honoraria from Pfizer, Forest, Cypress Biosciences, Pierre Fabre, UCB, and AstraZeneca (less than $10,000 each). | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor ; Dr. Harris has received consulting fees and honoraria from Pfizer (less than $10,000) as well as research grant funding from Pfizer. | en_US |
dc.contributor.affiliationother | Massachusetts General Hospital, Charlestown, and Logan College of Chiropractic, Chesterfield, Missouri ; Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteenth Street #2301, Charlestown, MA 02129 | en_US |
dc.contributor.affiliationother | Massachusetts General Hospital, Charlestown | en_US |
dc.contributor.affiliationother | Kyunghee University, Yongin, Korea | en_US |
dc.identifier.pmid | 20506181 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/77979/1/27497_ftp.pdf | |
dc.identifier.doi | 10.1002/art.27497 | en_US |
dc.identifier.source | Arthritis & Rheumatism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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