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The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine

dc.contributor.authorButler, David L.en_US
dc.contributor.authorGoldstein, Steven A.en_US
dc.contributor.authorGuldberg, Robert E.en_US
dc.contributor.authorGuo, X. Edwarden_US
dc.contributor.authorKamm, Rogeren_US
dc.contributor.authorLaurencin, Cato T.en_US
dc.contributor.authorMcIntire, Larry V.en_US
dc.contributor.authorMow, Van C.en_US
dc.contributor.authorNerem, Robert M.en_US
dc.contributor.authorSah, Robert L.en_US
dc.contributor.authorSoslowsky, Louis J.en_US
dc.contributor.authorSpilker, Robert L.en_US
dc.contributor.authorTranquillo, Robert T.en_US
dc.date.accessioned2010-10-14T14:18:44Z
dc.date.available2010-10-14T14:18:44Z
dc.date.issued2009-12en_US
dc.identifier.citationButler, David L.; Goldstein, Steven A.; Guldberg, Robert E.; Guo, X. Edward; Kamm, Roger; Laurencin, Cato T.; McIntire, Larry V.; Mow, Van C.; Nerem, Robert M.; Sah, Robert L.; Soslowsky, Louis J.; Spilker, Robert L.; Tranquillo, Robert T. (2009/07/07). "The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine." Tissue Engineering Part B: Reviews, 15(4): 477-484 <http://hdl.handle.net/2027.42/78125>en_US
dc.identifier.issn1937-3368en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/78125
dc.description.abstractBiomechanical factors profoundly influence the processes of tissue growth, development, maintenance, degeneration, and repair. Regenerative strategies to restore damaged or diseased tissues in vivo and create living tissue replacements in vitro have recently begun to harness advances in understanding of how cells and tissues sense and adapt to their mechanical environment. It is clear that biomechanical considerations will be fundamental to the successful development of clinical therapies based on principles of tissue engineering and regenerative medicine for a broad range of musculoskeletal, cardiovascular, craniofacial, skin, urinary, and neural tissues. Biomechanical stimuli may in fact hold the key to producing regenerated tissues with high strength and endurance. However, many challenges remain, particularly for tissues that function within complex and demanding mechanical environments in vivo. This paper reviews the present role and potential impact of experimental and computational biomechanics in engineering functional tissues using several illustrative examples of past successes and future grand challenges.en_US
dc.format.extent362208 bytes
dc.format.extent3100 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherMary Ann Liebert, Inc.en_US
dc.titleThe Impact of Biomechanics in Tissue Engineering and Regenerative Medicineen_US
dc.typeArticleen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid19583462en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78125/1/ten.teb.2009.0340.pdf
dc.identifier.doi10.1089/ten.teb.2009.0340en_US
dc.identifier.sourceTissue Engineering Part B: Reviewsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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