Now showing items 31-40 of 49
Folylpolyglutamates as substrates and inhibitors of folate-dependent enzymes
(Elsevier, 1987)
The true intracellular substrates for folate-dependent enzymes are folylpolyglutamates. We have used measurements of the Ki values of folylpolyglutamate dead end inhibitors to assess the relative affinities of folate-dependent ...
Modulation of methylenetetrahydrofolate reductase activity by S-adenosylmethionine and by dihydrofolate and its polyglutamate analogues
(Elsevier, 1982)
Methylenetetrahydrofolate reductase catalyzes the reduction of methylenetetrahydrofolate ot methyltetrahydrofolate. This reaction commits one carbon units to the pathways of adenosylmethionine-dependent methylation in ...
Alternate substrates and inhibitors of 1-aminocyclopropane-1-carboxylic acid synthase
(Elsevier, 1987-06)
Structural analogs of (-)-S-adenosyl--methionine (SAM), in which the heterocyclic base was modified, were used to initiate studies to elucidate the active site conformation of the enzyme 1-aminocyclopropane-1-carboxylic ...
Simultaneous enzymatic/electrochemical determination of glucose and L -glutamine in hybridoma media by flow-injection analysis.
(Wiley Subscription Services, Inc., A Wiley Company, 1993-04-25)
A split-stream flow-injection analysis system is described for simultaneous determination of glucose and L -glutamine in serum-free hybridoma bioprocesses media. Amperometric measurement of glucose is based on anodic ...
Properties of the cyanobacterial coupling factor ATPase from Spirulina platensis : I. Electrophoretic characterization and reconstitution of photophosphorylation
(Elsevier, 1986-02-15)
The coupling factor ATPase (F1) from photosynthetic membranes of the cyanobacterium Spirulina platensis was purified to homogeneity by a combination of ion-exchange chromatography and sucrose density gradient centrifugation. ...
Improved synthesis and biological evaluation of an acyclic thiosangivamycin active against human cytomegalovirus
(Elsevier, 1992-07-01)
We previously described the synthesis and in vitro antiviral activity of an acyclic thiosangivamycin analog (Gupta et al., 1989a). In order to extend these initial studies, a new, multi-gram synthesis of 4-amino-7-[(2-hy ...
Electron exchange coupling in a naturally occurring tetramangano cluster in the mineral helvite, (Mn4S)(SiBeO4)3
(Elsevier, 1985-06)
The mineral helvite, (Mn4S)(BeSiO4)3, contains discrete tetrahedral Mn4S+6 clusters in which the S-2 is tetrahedrally coordinated and each Mn(II) is in a distorted tetrahedron of one S-2 and three oxygens; the cluster is ...