Now showing items 11-15 of 15
Integrative biology and the developing limb bud 1
(Blackwell Science Inc, 2002-09)
The identification or selective construction of mutations within genes has allowed researchers to explore the downstream effects of gene disruption. Although these approaches have been successful, a limitation in our ...
Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication
(Blackwell Science Inc, 2004-11)
The posterior HoxA and HoxD genes are essential in appendicular development. Studies have demonstrated that a “distal limb enhancer,” remotely located upstream of the HoxD complex, is required to drive embryonic autopod ...
Molecular basis of pituitary dysfunction in mouse and human
(Springer-Verlag; Springer-Verlag New York Inc., 2001-07)
DQX1, an RNA-dependent ATPase homolog with a novel DEAQ box: expression pattern and genomic sequence comparison of the human and mouse genes
(Springer-Verlag; Springer-Verlag New York Inc., 2001-06)
DQX1 is a novel gene related to the RNA-dependent ATPases. The gene was classified as a member of the DEAD/H family on the basis of the conserved order and spacing of ten short protein motifs. The unique features of DQX1 ...
Allelic mutations of the sodium channel SCN8A reveal multiple cellular and physiological functions
(Kluwer Academic Publishers; Springer Science+Business Media, 2004-09)
Allelic mutations of Scn8a in the mouse have revealed the range of neurological disorders that can result from alternations of one neuronal sodium channel. Null mutations produce the most severe phenotype, with motor neuron ...