Now showing items 51-57 of 57
Modifications to the Patient Rule-Induction Method that utilize non-additive combinations of genetic and environmental effects to define partitions that predict ischemic heart disease
(Wiley Subscription Services, Inc., A Wiley Company, 2009-05)
This article extends the Patient Rule-Induction Method (PRIM) for modeling cumulative incidence of disease developed by Dyson et al. (Genet Epidemiol 31:515–527) to include the simultaneous consideration of non-additive ...
The Interface Between the Practice of Medical Genetics and Human Genetic Research: What Every Genetic Counselor Needs to Know
(Kluwer Academic Publishers-Plenum Publishers; National Society of Genetic Counselors, Inc. ; Springer Science+Business Media, 2004-10)
Genetic counselors have historically used human genetic research as an advanced information resource for their patients. Most commonly, this has been via access to information provided by gene identification studies in ...
DQX1, an RNA-dependent ATPase homolog with a novel DEAQ box: expression pattern and genomic sequence comparison of the human and mouse genes
(Springer-Verlag; Springer-Verlag New York Inc., 2001-06)
DQX1 is a novel gene related to the RNA-dependent ATPases. The gene was classified as a member of the DEAD/H family on the basis of the conserved order and spacing of ten short protein motifs. The unique features of DQX1 ...
Characterization of a mutagenic B1 retrotransposon insertion in the jittery mouse Communicated by Haig H. Kazazian
(Wiley Subscription Services, Inc., A Wiley Company, 2004-07)
B1 elements are an abundant class of short interspersed elements (SINEs) in the mouse genome and mobilize by a process known as retrotransposition. Here, we report the characterization of a mutagenic B1 insertion into exon ...
An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart disease
(Wiley Subscription Services, Inc., A Wiley Company, 2007-09)
Different combinations of genetic and environmental risk factors are known to contribute to the complex etiology of ischemic heart disease (IHD) in different subsets of individuals. We employed the Patient Rule-Induction ...
Transpiration-based micropump for delivering continuous ultra-low flow rates
(IOP Publishing Ltd, 2003-03-01)
In this paper we describe the design, construction and operation of a micropump that delivers continuous, ultra-low flow velocities at ∼100 μm s−1. The pumping concept is based on the commonly observed phenomenon of ...
Allelic mutations of the sodium channel SCN8A reveal multiple cellular and physiological functions
(Kluwer Academic Publishers; Springer Science+Business Media, 2004-09)
Allelic mutations of Scn8a in the mouse have revealed the range of neurological disorders that can result from alternations of one neuronal sodium channel. Null mutations produce the most severe phenotype, with motor neuron ...