Now showing items 1-10 of 49
Synthesis of normal and variant human hypoxanthine-guanine phosphoribosyltransferase in Escherichia coli
(Elsevier, 1993-01-30)
Naturally occurring mutations in hypoxanthine-guanine phosphoribosyltransferase (HPRT) have been identified by amino acid sequencing, cDNA cloning, and direct nucleotide sequencing of PCR-amplified transcripts. To determine ...
Adenovirus-Mediated Transfer of the CFTR Gene to Lung of Nonhuman Primates: Biological Efficacy Study
(Mary Ann Liebert, Inc., publishers, 1993-12-01)
Overview summary Recombinant adenoviruses hold tremendous promise for gene therapies of lung disease in cystic fibrosis (CF). An evaluation of the feasibility and safety of this technology in nonhuman primates is critical ...
Double Retrograde Atrial Response After Radiofrequency Ablation of Typical AV Nodal Reentrant Tachycardia
(Blackwell Publishing Ltd, 1993-12)
Cultured adult rat jejunal explants as a model for studying regulation of CYP3A
(Elsevier, 1993-09-01)
Enzymes within the CYP3A subfamily are major Phase I drug-metabolizing enzymes present in hepatocytes and small bowel enterocytes. These enzymes are highly inducible in the liver by many structurally diverse compounds, ...
Detection of intraarticular abnormalities in osteoarthritis of the knee
(John Wiley & Sons, Inc., 1993-10)
Objective. To determine whether intraarticular abnormalities in osteoarthritis (OA) of the knee can be detected as well by needle arthroscopy as by standard arthroscopy. Methods. Needle arthroscopy followed by standard ...
Atrioventricular conduction in children of women with systemic lupus erythematosus
(Elsevier, 1993-01-01)
The neonatal lupus syndrome consists of transient cutaneous lupus lesions or permanent congenital complete heart block (or hepatic fibrosis), or both, in infants born to mothers with systemic lupus erythematosus (SLE). The ...
Evidence that macrophages are programmed to die after activating autologous, cloned, antigen-specific, CD4 + T cells
(WILEY-VCH Verlag GmbH, 1993-07)
The bone marrow produces large numbers of monocytes daily, but the mechanisms balancing production and elimination are unknown. In this report we demonstrate that macrophages (Mφ) undergo apoptosis after activating autologous ...
Adenovirus-Mediated Transfer of the CFTR Gene to Lung of Nonhuman Primates: Toxicity Study
(Mary Ann Liebert, Inc., publishers, 1993-12-01)
Overview summary Experiments in small animals support the feasibility of recombinant adenoviruses for treating CF lung disease. Studies in nonhuman primates are critical in assessing the potential toxicities associated ...
Factors Affecting Students' Use of MEDLINE
(Elsevier, 1993-12)
MEDLINE search transcripts by a class of third-year medical students were analyzed. The 184 students were divided into three groups according to their search experience in terms of the number of sessions logged at the time ...