Now showing items 1-10 of 24
CCK antagonists reveal that CCK-8 and JMV-180 interact with different sites on the rat pancreatic acinar cell CCKA receptor
(Elsevier, 1994)
The ability of CCKA antagonists to inhibit full and partial CCK agonists of the rat pancreatic acinar cell CCKA receptor has been studied. When isolated rat pancreatic acini were superfused with CCK-8 (10 pM-1 nM) or CCK-4 ...
Interactions of intracellular mediators of amylase secretion in permeabilized pancreatic acini
(Elsevier, 1991-01-23)
Mouse pancreatic acini were permeabilized with streptolysin O to investigate amylase secretion stimulated by various intracellular mediators and the kinetics of secretion as a function of temperature. Amylase secretion was ...
Studies on morpholinosphingolipids: Potent inhibitors of glucosylceramide synthase
(Elsevier, 1994-04-25)
Synthetic 1-morpholino-1-deoxyceramides were designed to inhibit glucosylceramide synthase. The most potent inhibitor 2a possesses the unnatural R,R-configuration of D-threo-sphingosine.
Augmentation of hepatic doxorubicin extraction with extracorporeal filtration avoids the dose-dependent, nonlinear increase in AUC observed with systemic administration
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1997-12)
Purpose : Regional therapy of primary or metastatic liver cancer with low hepatic extraction ratio drugs such as doxorubicin is constrained by development of systemic toxicity. To examine the effect of augmentation of ...
Endothelin increases [Ca2+]i in rat pancreatic acinar cells by intracellular release but fails to increase amylase secretion
(Elsevier, 1992-08-12)
In individual fura-2 loaded cells of rat pancreatic acini endothelin-1 (ET-1) (10-50 nM) induced sustained oscillations in [Ca2+]i. At higher concentrations a larger, but transient increase in [Ca2+]i was observed, which ...
Interactions of von Willebrand factor on mica studied by atomic force microscopy
(Elsevier, 1992-01)
Three-dimensional molecular level images of uncoated human von Willebrand factor (vWF), a plasma glycoprotein, have been obtained using atomic force microscopy (AFM). However, the structural detail obtained by AFM was found ...
Selective localization of radioiodinated alkylphosphocholine derivatives in tumors
(Elsevier, 1992-10)
We have designed and synthesized two radioiodinated analogs of hexadecylphosphocholine in order to evaluate their tumor imaging potential. 12-(m[125I]iodophenyl)dodecyl phosphocholine (NM-324) and hexadecyl-2-[N,N-dimeth ...
Modulation of Na+/alanine cotransport in liver sinusoidal membrane vesicles by internal divalent cations
(Elsevier, 1990-04-30)
Rat liver basolateral plasma membrane (bILPM) vesicles resuspended in 5 mM Mg2+-, Ca2+-, Mn2+- or Co2+-containing media exhibited a markedly lower rate of Na+-stimulated -alanine transport. Divalent cation inhibition of ...
Decreased formation of inositol trisphosphate in Madin-Darby canine kidney cells under conditions of [beta]-glucosidase inhibition
(Elsevier, 1992-02-01)
Recent work has demonstrated the enhancement of hormone-stimulated inositol trisphosphate formation in renal epithelial cells under conditions of glucosylceramide depletion. The role of glucosylceramide metabolism was ...
Ion-pair chromatography of inositol polyphosphates with N-methylimipramine
(Elsevier, 1990)
A novel counter-ion, N-methylimipramine, was synthesized and utilized in the separation of inositol phosphates by ion-pair chromatography. The structural identity of the counter-ion was documented by nuclear magnetic ...