Now showing items 31-40 of 86
A FRET analysis to unravel the role of cholesterol in Rac1 and PI 3-kinase activation in the InlB/Met signalling pathway
(Blackwell Publishing Ltd, 2007-03)
The signalling pathway for the hepatocyte growth factor receptor, Met/HGF-R, is hijacked by the bacterial surface protein InlB to induce Listeria monocytogenes entry into non-phagocytic cells. We previously showed that ...
A Microbial Strategy to Multiply in Macrophages: The Pregnant Pause
(Blackwell Science, Ltd, 2002-03)
Membrane perforations inhibit lysosome fusion by altering pH and calcium in Listeria monocytogenes vacuoles
(Blackwell Publishing Ltd, 2006-05)
Listeria monocytogenes ( Lm ) evade microbicidal defences inside macrophages by secreting a pore-forming cytolysin listeriolysin O (LLO), which allows Lm to escape vacuoles. LLO also inhibits Lm vacuole fusion with lysosomes, ...
Localization of protein kinase C ε to macrophage vacuoles perforated by Listeria monocytogenes cytolysin
(Blackwell Publishing Ltd, 2007-07)
Three proteins secreted by Listeria monocytogenes facilitate escape from macrophage vacuoles: the cholesterol-dependent cytolysin listeriolysin O (LLO), a phosphoinositide-specific phospholipase C (PI-PLC) and a broad-range ...
Autophagy is an immediate macrophage response to Legionella pneumophila
(Blackwell Science Ltd, 2005-06)
After ingestion by macrophages, Legionella pneumophila enter spacious vacuoles that are quickly enveloped by endoplasmic reticulum (ER), then slowly transferred to lysosomes. Here we demonstrate that the macrophage autophagy ...
Control of mucosal polymicrobial populations by innate immunity
(Blackwell Publishing Ltd, 2009-09)
The gastrointestinal tract carries out the complex process of localizing the polymicrobial populations of the indigenous microbiota to the lumenal side of the GI mucosa while absorbing nutrients from the lumen and preventing ...
Mathematical and computational approaches can complement experimental studies of host–pathogen interactions
(Blackwell Publishing Ltd, 2009-04)
In addition to traditional and novel experimental approaches to study host–pathogen interactions, mathematical and computer modelling have recently been applied to address open questions in this area. These modelling tools ...
A criterion for using chloramphenicol to define different processes in the initiation of DNA synthesis in bacteria
(Elsevier, 1974-07)
A criterion is proposed which must be met in order to demonstrate that two different proteins are required for the initiation of DNA synthesis, with each protein being synthesized at a different time prior to initiation, ...
Feedforward inhibition in biosynthetic pathways: inhibition of the aminoacyl-tRNA synthetase by intermediates of the pathway
(Elsevier, 1979-04-21)
The stability of an amino acid biosynthetic pathway controlled by end-product inhibition is significantly improved if, in addition, the corresponding aminoacyl-tRNA synthetase is inhibited by an intermediate in the pathway. ...