Now showing items 11-15 of 15
Cancer SLC43A2 alters T cell methionine metabolism and histone methylation
(Springer Nature, 2020-09-10)
Abnormal epigenetic patterns correlate with effector T cell malfunction in tumours1–4, but the cause of this link is unknown. Here we show that tumour cells disrupt methionine metabolism in CD8+ T cells, thereby lowering ...
Crotonylation at serine 46 impairs p53 activity
(Elsevier, 2020-04-09)
Post-translational modifications (PTMs) play pivotal roles in controlling the stability and activity of the tumor suppressor p53 in response to distinct stressors. Here we report an unexpected finding of a short chain fatty ...
Co-targeting p53-R249S and CDK4 synergistically suppresses survival of hepatocellular carcinoma cells
(Taylor & Francis, 2020-03-03)
p53-R249S (p53-RS) is frequently detected in human hepatocellular carcinoma (HCC) that is highly associated with hepatitis B infection and aflatoxin B1 exposure. Our previous study showed that CDK4/Cyclin D1 phosphorylates ...
RNA-binding motif protein 10 induces apoptosis and suppresses proliferation by activating p53
(Springer Nature, 2020-01-30)
RNA-binding motif protein 10 (RBM10) is an RNA-binding protein frequently deleted or mutated in lung cancer cells. Recent reports showed that the knockdown of RBM10 in human cancer cells enhances the growth of mouse tumor ...
The histone methyltransferase MLL1/KMT2A in monocytes drives coronavirus-associated coagulopathy and inflammation
(American Society of Hematology, 2023-01-01)
Coronavirus-associated coagulopathy (CAC) is a morbid and lethal sequela of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. CAC results from a perturbed balance between coagulation and fibrinolysis ...