Now showing items 1-10 of 30
Induction of glutathione S -transferase-Π in Barrett's metaplasia and Barrett's adenocarcinoma cell lines
(John Wiley & Sons, Inc., 1999-02)
Barrett's metaplasia consists of columnar epithelium that replaces the normal esophageal mucosa in patients with chronic gastroesophageal reflux. Because intestinal-type Barrett's metaplasia is the major risk factor for ...
Effects of dimethyl sulfoxide on the globally ischemic heart: Possible general relevance to hypothermic organ preservation
(Elsevier, 1982-02)
Isolated perfused rabbit hearts were made globally ischemic for 2 hr, then reperfused. For 5 min before and after ischemia hearts were perfused with hypothermic (20 or 27 [deg]C), hypoxic, substrate-free cardioplegic ...
Concurrent cisplatin, paclitaxel, and radiotherapy as preoperative treatment for patients with locoregional esophageal carcinoma
(Wiley Subscription Services, Inc., A Wiley Company, 2003-11-15)
BACKGROUND A Phase II trial was conducted at the University of Michigan to determine the efficacy of a preoperative regimen of concurrent cisplatin, paclitaxel, and radiation for patients with locoregional esophageal ...
Is there a benefit to sentinel lymph node biopsy in patients with T4 melanoma?
(Wiley Subscription Services, Inc., A Wiley Company, 2009-12-15)
BACKGROUND: Controversy exists as to whether patients with thick (Breslow depth >4 mm), clinically lymph node-negative melanoma require sentinel lymph node (SLN) biopsy. The authors examined the impact of SLN biopsy on ...
Distal chromosome 17q loss in Barrett's esophageal and gastric cardia adenocarcinomas: Implications for tumorigenesis
(John Wiley & Sons, Inc., 1998-08)
The molecular genetic mechanisms underlying esophageal cancer are poorly understood. However, a novel gene that may be involved in esophageal carcinogenesis was recently localized by others to distal 17q by linkage analysis ...
Finite proliferative lifespan in vitro of a human breast cancer cell strain isolated from a metastatic lymph node
(Kluwer Academic Publishers; Springer Science+Business Media, 1993-01)
We recently described culture conditions that allow proliferation of metastatic human breast cancer cells from biopsy specimens of certain patient samples. These conditions resulted in the development of an immortalized ...
Substitution of D-Trp 32 in NPY Destabilizes the Binding Transition State to the Y1 Receptor Site in SK-N-MC Cell Membranes
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1997-04)
The retention rate of the spin label 3-isothiocyanto methyl-2,2,5,5-tetramethyl-1-pyrrolidinyl oxyl spin label (proxyl) attached to the porcine N-acetyl-NPY peptide and the porcine N-acetyl-D-Trp 32 -NPY peptide at Lys 4 ...
RhoC-GTPase is a Novel Tissue Biomarker Associated with Biologically Aggressive Carcinomas of the Breast
(Kluwer Academic Publishers; Springer, 2005-09)
Background. There is a need for reliable predictors of breast cancer aggressiveness that will further refine the staging classification and help guide the implementation of novel therapies. We have identified RhoC as being ...
Do cancer centers designated by the National Cancer Institute have better surgical outcomes?
(Wiley Subscription Services, Inc., A Wiley Company, 2005-02-01)
BACKGROUND The National Cancer Institute (NCI) designates cancer centers as regional centers of excellence in research and patient care. Although these centers often advertise their superior outcomes, their relative ...
Merkel cell carcinoma: Critical review with guidelines for multidisciplinary management
(Wiley Subscription Services, Inc., A Wiley Company, 2007-07-01)
Merkel cell carcinoma (MCC) is a relatively rare cutaneous malignancy that occurs predominantly in the older white population. The incidence of MCC appears to have tripled during the past 20 years; an increase that is ...