Predicting chemical impacts on vertebrate endocrine systems
dc.contributor.author | Nichols, John W. | en_US |
dc.contributor.author | Breen, Miyuki | en_US |
dc.contributor.author | Denver, Robert John | en_US |
dc.contributor.author | DiStefano, Joseph J. | en_US |
dc.contributor.author | Edwards, Jeremy S. | en_US |
dc.contributor.author | Hoke, Robert A. | en_US |
dc.contributor.author | Volz, David C. | en_US |
dc.contributor.author | Zhang, Xiaowei | en_US |
dc.date.accessioned | 2011-01-04T16:24:12Z | |
dc.date.available | 2012-02-21T18:47:01Z | en_US |
dc.date.issued | 2011-01 | en_US |
dc.identifier.citation | Nichols, John W.; Breen, Miyuki; Denver, Robert J.; DiStefano, Joseph J.; Edwards, Jeremy S.; Hoke, Robert A.; Volz, David C.; Zhang, Xiaowei (2011). "Predicting chemical impacts on vertebrate endocrine systems." Environmental Toxicology and Chemistry 30(1): 39-51. <http://hdl.handle.net/2027.42/78495> | en_US |
dc.identifier.issn | 0730-7268 | en_US |
dc.identifier.issn | 1552-8618 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78495 | |
dc.description.abstract | Animals have evolved diverse protective mechanisms for responding to toxic chemicals of both natural and anthropogenic origin. From a governmental regulatory perspective, these protective responses complicate efforts to establish acceptable levels of chemical exposure. To explore this issue, we considered vertebrate endocrine systems as potential targets for environmental contaminants. Using the hypothalamic-pituitary-thyroid (HPT), hypothalamic-pituitary-gonad (HPG), and hypothalamic-pituitary-adrenal (HPA) axes as case examples, we identified features of these systems that allow them to accommodate and recover from chemical insults. In doing so, a distinction was made between effects on adults and those on developing organisms. This distinction was required because endocrine system disruption in early life stages may alter development of organs and organ systems, resulting in permanent changes in phenotypic expression later in life. Risk assessments of chemicals that impact highly regulated systems must consider the dynamics of these systems in relation to complex environmental exposures. A largely unanswered question is whether successful accommodation to a toxic insult exerts a fitness cost on individual animals, resulting in adverse consequences for populations. Mechanistically based mathematical models of endocrine systems provide a means for better understanding accommodation and recovery. In the short term, these models can be used to design experiments and interpret study findings. Over the long term, a set of validated models could be used to extrapolate limited in vitro and in vivo testing data to a broader range of untested chemicals, species, and exposure scenarios. With appropriate modification, Tier 2 assays developed in support of the U.S. Environmental Protection Agency's Endocrine Disruptor Screening Program could be used to assess the potential for accommodation and recovery and inform the development of mechanistically based models. Environ. Toxicol. Chem. 2011;30:39–51. © 2010 SETAC | en_US |
dc.format.extent | 451602 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Environmental Chemistry | en_US |
dc.subject.other | Ecotoxicology and Pollution Science | en_US |
dc.title | Predicting chemical impacts on vertebrate endocrine systems | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | U.S. Environmental Protection Agency, Duluth, Minnesota ; U.S. Environmental Protection Agency, Duluth, Minnesota. | en_US |
dc.contributor.affiliationother | U.S. Environmental Protection Agency, Research Triangle Park, North Carolina ; North Carolina State University, Raleigh, North Carolina, USA | en_US |
dc.contributor.affiliationother | University of California, Los Angeles, California, USA | en_US |
dc.contributor.affiliationother | University of New Mexico, Albuquerque, New Mexico, USA | en_US |
dc.contributor.affiliationother | Dupont Haskell Laboratory, Newark, Delaware, USA | en_US |
dc.contributor.affiliationother | University of South Carolina, Columbia, South Carolina, USA | en_US |
dc.contributor.affiliationother | University of Saskatchewan, Saskatoon, Saskatchewan, Canada | en_US |
dc.identifier.pmid | 20963851 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78495/1/376_ftp.pdf | |
dc.identifier.doi | 10.1002/etc.376 | en_US |
dc.identifier.source | Environmental Toxicology and Chemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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